PedsQL™ Cognitive Functioning Scale in pediatric liver transplant recipients: feasibility, reliability, and validity
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The PedsQL™ (Pediatric Quality of Life Inventory™) is a modular instrument designed to measure health-related quality of life and disease-specific symptoms. The PedsQL™ Cognitive Functioning Scale was developed as a brief generic symptom-specific instrument to measure cognitive functioning. The objective of the present study was to determine the feasibility, reliability, and validity of the PedsQL™ Cognitive Functioning Scale in pediatric liver transplant recipients.
The 6-item PedsQL™ Cognitive Functioning Scale and the PedsQL™ 4.0 Generic Core Scales were completed by pediatric liver transplant recipients ages 8–18 years (n = 215) and parents of pediatric liver transplant recipients ages 2–18 years (n = 502). Both patient self-report and parent proxy-report were available for 212 cases. The 72-item Behavior Rating Inventory of Executive Function (BRIEF), a widely validated measure of executive functioning, was completed by 100 parents and 56 teachers on a subset of patients.
The PedsQL™ Cognitive Functioning Scale demonstrated minimal missing responses (0.0%, child report, 0.67%, parent report), achieved excellent reliability (α = 0.88 child report, 0.94 parent report), distinguished between pediatric patients with liver transplants and healthy children supporting discriminant validity, and was significantly correlated with the PedsQL™ 4.0 Generic Core Scales and the BRIEF supporting construct and concurrent validity, respectively. Pediatric liver transplants recipients experienced cognitive functioning comparable to long-term pediatric cancer survivors.
The results demonstrate the feasibility, reliability, discriminant, construct, and concurrent validity of the PedsQL™ Cognitive Functioning Scale in pediatric liver transplant recipients.
KeywordsCognitive functioning PedsQL™ Liver transplant Pediatrics Executive functioning Quality of life
- 1.Weissberg-Benchell, J., Zielinski, T. E., Rodgers, S., Greenley, R. N., Askenazi, D., Goldstein, S. L., et al. (2010). Pediatric health-related quality of life: Feasibility, reliability and validity of the PedsQL™ Transplant Module. American Journal of Transplantation, 10, 1677–1685.PubMedCrossRefGoogle Scholar
- 7.Sorensen, L. G., Neighbors, K., Martz, K., Zelko, F., Bucuvalas, J. C., & Alonso, E. M. (in press). Cognitive and academic outcomes after pediatric liver transplantation: Functional outcomes group (FOG) results. American Journal of Transplantation.Google Scholar
- 8.Varni, J. W., Burwinkle, T. M., Katz, E. R., Meeske, K., & Dickinson, P. (2002). The PedsQL™ in pediatric cancer: Reliability and validity of The Pediatric Quality of Life Inventory™ Generic Core Scales, Multidimensional Fatigue Scale, and cancer module. Cancer, 94, 2090–2106.PubMedCrossRefGoogle Scholar
- 9.McCarthy, M. L., MacKenzie, E. J., Durbin, D. R., Aitken, M. E., Jaffe, K. M., Paidas, C. N., et al. (2005). The Pediatric Quality of Life Inventory: An evaluation of its reliability and validity for children with traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 86, 1901–1909.PubMedCrossRefGoogle Scholar
- 21.Limbers, C. A., Heffer, R. W., & Varni, J. W. (2009). Health-related quality of life and cognitive functioning from the perspective of parents of school-aged children with Asperger’s Syndrome utilizing the PedsQL™. Journal of Autism and Developmental Disorders, 39, 1529–1541.PubMedCrossRefGoogle Scholar
- 30.Gioia, G. A., Isquith, P. K., Guy, S. C., & Kenworthy, L. (2000). Behavior rating inventory of executive function. Odessa, FL: Psychological Assessment Resources.Google Scholar
- 34.Nunnally, J. C., & Bernstein, I. R. (1994). Psychometric theory (3rd ed.). New York: McGraw-Hill.Google Scholar
- 36.Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences (2nd ed.). Hillsdale, NJ: Erlbaum.Google Scholar
- 37.Pedhazur, E. J., & Schmelkin, L. P. (1991). Measurement, design, and analysis: An integrated approach. Hillsdale, NJ: Erlbaum.Google Scholar
- 40.SPSS. (2008). SPSS 16.0 for windows. Chicago: SPSS, Inc.Google Scholar
- 43.Varni, J. W., Limbers, C. A., & Burwinkle, T. M. (2007). Parent proxy-report of their children’s health-related quality of life: An analysis of 13, 878 parents’ reliability and validity across age subgroups using the PedsQL™ 4.0 Generic Core Scales. Health and Quality of Life Outcomes, 5(2), 1–10.PubMedCrossRefGoogle Scholar