The RSM-scale: a pilot study on a new specific scale for self- and observer-rated quality of life in patients with schizophrenia
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To develop and evaluate a self- and observer-rating scale on quality of life in patients suffering from schizophrenia with regard to the efficacy of atypical antipsychotics based on different dimensions and to apply within a pilot study.
Following review of existing scales and a prevalidation phase, the Riedel-Spellmann-Musil (RSM) scale was developed comprising 36 items assigned to different subscales. As reference scales, the Quality of Life Scale (QLS) and the Subjective Well-being Under Neuroleptic Treatment Scale—short version (SWN-K) were performed, psychopathology and adverse events were measured at all visits. Reliability was assessed using Cronbach’s alpha, Pearson’s correlation coefficients were used to assess construct validity, and Intraclass Correlation Coefficients (ICCs) were used for test–retest reliability. T tests were performed in normal distributed samples; otherwise Wilcoxon tests were used.
One hundred and thirty-six patients were included in the study. Cronbach`s α was 0.917 for the self-rating and 0.915 for the interviewer-rating part. ICCs were >0.70 for all subscales. The self-rating part correlated strongly with the SWN-K and the observer part with the QLS. Changes in psychopathology over the study period and different levels of functioning were detected.
The RSM-scale is a new scale to assess the quality of life in different dimensions of patients with schizophrenia treated with antipsychotics and shows good internal consistency, test–retest reliability, construct and discriminant validity.
KeywordsSchizophrenia Atypical antipsychotics Quality of life Subjective well-being Scale development
Subjective Well-being Under Neuroleptic Treatment Scale—short version
Quality of Life Scale
Personal and Social Performance Scale
Short Form (36) Health Survey
Positive and Negative Syndrome Scale
Clinical Global Impression Scale—Severity
Global Assessment of Functioning Scale
Extrapyramidal Symptom Rating Scale
Udvalg for Klniske Undersogelser Scale
Health-Related Quality of Life
Diagnostic and statistical manual of mental disorders, fourth edition
We would like to thank all participants of the expert discussions, Prof. R. Engel for advice in scale development and the clinicians for recruiting and rating the patients, namely A. Cerovecki, S. Dehning, L. de la Fontaine, I. Hermisson, K. Maino, J. Matz, E. Karamatskos, M. Opgen-Rhein, F. Seemüller, R. Zimmermann, B. Hock and K. Janjic and F. Meister for creating the database. The RSM-scale is available for researchers by contacting M. Riedel, Department of Psychiatry and Psychotherapy of LMU, Munich, firstname.lastname@example.org. The English translation (not validated) of the German version of the scale is to be found in the appendix. The study was financially supported by AstraZeneca. Study design, scale development, scale validation, manuscript preparation and review were performed without any input of AstraZeneca.
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