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Quality of Life Research

, Volume 19, Issue 1, pp 65–80 | Cite as

Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire

  • Helen DakinEmail author
  • Stavros Petrou
  • Mark Haggard
  • Sarah Benge
  • Ian Williamson
Article

Abstract

Purpose

To investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores.

Methods

A placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores.

Results

OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error: 0.134 with HL and 0.132 without; R 2: 0.63 with HL and 0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difficulties, predicted HL, age and sex also produced accurate predictions.

Conclusion

Regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME.

Keywords

Otitis media Glue ear Quality of life Health state preference value Utility mapping Cross-walking 

Abbreviations

ACET

Air conduction estimated from tympanometry

AIC

Akaike information criterion

DEV

Developmental domain of the OM8-30

ENT

Ear, nose and throat

GLM

Generalised linear model(s)

GNOME

GPRF [General Practice Research Framework] Nasal steroids for Otitis Media with Effusion

HL

Hearing level

HRQoL

Health-related quality of life

HUI

Health Utilities Index

MAE

Mean absolute error

MAEVal

Mean absolute error for the validation dataset

OLS

Ordinary least squares [regression]

OM8-30

Otitis media questionnaire

OME

Otitis media with effusion

PHYS

Physical health domain of the OM8-30

PQoL

Parent quality of life

QALY

Quality-adjusted life-year

RHD

Reported hearing difficulties

RMSE

Root mean squared error

SD

Standard deviation

Notes

Acknowledgments

The authors would like to thank all researchers who were involved in the GNOME trial, in addition to the children and parents who participated. In particular, we would like to thank Giselle Abangma for preparing the dataset of HUI utilities, Helen Spencer for preparing datasets of OM8-30 question, facet and domain scores and predicted hearing levels and the two anonymous reviewers for their helpful comments on the manuscript. This project was funded by the UK National Institute for Health Research Health Technology Assessment Programme (project number 01/72/02). The views and opinions expressed are those of the authors and do not necessarily reflect those of the Department of Health.

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Helen Dakin
    • 1
    Email author
  • Stavros Petrou
    • 1
    • 2
  • Mark Haggard
    • 3
  • Sarah Benge
    • 4
  • Ian Williamson
    • 4
  1. 1.Health Economics Research Centre, Department of Public HealthUniversity of OxfordHeadingtonUK
  2. 2.National Perinatal Epidemiology UnitUniversity of OxfordHeadingtonUK
  3. 3.MRC Multi-centre Otitis Media Study Group, Department of Experimental PsychologyUniversity of CambridgeCambridgeUK
  4. 4.Primary Medical CareUniversity of Southampton, Aldermoor Health CentreSouthamptonUK

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