Quality of life of patients with irritable bowel syndrome in Korea
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The impact of irritable bowel syndrome (IBS) on HRQOL has been widely studied in the West. However, there are few data from Asian countries. The aim of this study was to assess the health-related quality of life (HRQOL) of patients suffering from IBS in Korea.
Consecutive patients from six secondary and six tertiary medical centers in Korea were enrolled and completed self-administered questionnaires on sociodemographics and IBS-associated symptoms. HRQOL was assessed using the generic Short Form 36 (SF-36) and the disease-specific IBS-QOL questionnaires.
Of the 932 patients with abdominal pain and bowel symptoms, 664 IBS patients who fulfilled the Rome II criteria were analyzed. On all eight SF-36 scales, IBS patients had a significantly worse HRQOL than the general population (P < 0.01). The overall score for the IBS-QOL was 74.2. The health concern domain was most affected (mean score 64.2), and the sexual domain (mean score 86.7) was least affected in the IBS-QOL. Significant impairment of HRQOL was only observed in patients with severe symptoms both in the generic and specific HRQOL measurement, whereas patients with mild and moderate symptoms showed only mild impairment (P < 0.01). Female patients reported a significantly lower HRQOL than male patients (P < 0.05), but the difference was minimal. The IBS-QOL was significantly associated with female gender, total symptom score, self-reported symptom severity, and level of education in the multivariate analysis.
IBS-related symptoms had a great effect on the HRQOL of Korean patients. These results and the considerable prevalence of IBS in Korea indicate that IBS has a substantial social impact in this country.
KeywordsIrritable bowel syndrome Quality of life Symptom SF-36 IBS-QOL
Irritable bowel syndrome
Constipation-predominant irritable bowel syndrome
Diarrhea-predominant irritable bowel syndrome
Mixed type irritable bowel syndrome
Quality of life
Short Form 36
Irritable bowel syndrome-quality of life measure
Health-related quality of life
Analysis of variance
We thank Donald L. Patrick for kindly consenting to the use of the IBS-QOL in Korea.
This work was funded by grants from The Korean Society of Neurogastroenterology and Motility by Novartis Pharmaceuticals Corporation, Korea.
- 8.Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., Müller-Lissner, S. A.(2000). Functional bowel disorders and functional abdominal pain. In Rome II: The functional gastrointestinal disorders: Diagnosis, pathophysiology and treatment; A multinational consensus. McLean, VA: Degnon and Associates.Google Scholar
- 12.Drossman, D., Morris, C. B., Hu, Y., Toner, B. B., Diamant, N., Whitehead, W. E., et al. (2007). Characterization of health related quality of life (HRQOL) for patients with functional bowel disorder (FBD) and its response to treatment. The American Journal of Gastroenterology, 102(7), 1442–1453. doi: 10.1111/j.1572-0241.2007.01283.x.PubMedCrossRefGoogle Scholar
- 13.Kanazawa, M., Drossman, D. A., Shinozaki, M., Sagami, Y., Endo, Y., Palsson, O. S., et al. (2007). Translation and validation of a Japanese version of the irritable bowel syndrome-quality of life measure (IBS-QOL-J). BioPsychoSocial Medicine, 3, 1–6.Google Scholar
- 14.Kanazawa, M., Endo, Y., Whitehead, W. E., Kano, M., Hongo, M., & Fukudo, S. (2004). Patients and nonconsulters with irritable bowel syndrome reporting a parental history of bowel problems have more impaired psychological distress. Digestive Diseases and Sciences, 49(6), 1046–1053. doi: 10.1023/B:DDAS.0000034570.52305.10.PubMedCrossRefGoogle Scholar
- 23.Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., et al. (1998). Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology, 95(3), 701–708.Google Scholar
- 24.Akehurst, R. L., Brazier, J. E., Mathers, N., O’Keefe, C., Kaltenthaler, E., Morgan, A., et al. (2002). Health-related quality of life and cost impact of irritable bowel syndrome in a UK primary care setting. PharmacoEconomics, 20(7), 455–462. doi: 10.2165/00019053-200220070-00003.PubMedCrossRefGoogle Scholar
- 26.Spiegel, B. M., Gralnek, I. M., Bolus, R., Chang, L., Dulai, G. S., Mayer, E. A., et al. (2004). Clinical determinants of health-related quality of life in patients with irritable bowel syndrome. Archives of Internal Medicine, 164(16), 1773–1780. doi: 10.1001/archinte.164.16.1773.PubMedCrossRefGoogle Scholar
- 33.Hahn, B. A., Kirchdoerfer, L. J., Fullerton, S., & Mayer, E. (1997). Patient-perceived severity of irritable bowel syndrome in relation to symptoms, health resource utilization and quality of life. Alimentary Pharmacology and Therapeutics, 11(3), 553–559. doi: 10.1046/j.1365-2036.1997.00160.x.PubMedCrossRefGoogle Scholar
- 35.Tillisch, K., Labus, J. S., Naliboff, B. D., Bolus, R., Shetzline, M., Mayer, E. A., et al. (2005). Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome. The American Journal of Gastroenterology, 100(4), 896–904. doi: 10.1111/j.1572-0241.2005.41211.x.PubMedCrossRefGoogle Scholar