Quality of Life Research

, 17:1207 | Cite as

Changes in health-related quality of life (HRQoL) in a population-based sample of children and adolescents after 3 years of follow-up

  • J. A. Palacio-Vieira
  • E. Villalonga-Olives
  • J. M. Valderas
  • M. Espallargues
  • M. Herdman
  • S. Berra
  • J. Alonso
  • L. RajmilEmail author



To assess changes in health-related quality of life (HRQoL) in children and adolescents over a 3-year period and to examine factors associated with change.


A representative sample of Spanish children and adolescents aged 8–18 years and their parents completed the KIDSCREEN-52 questionnaire at baseline and again after 3 years. Data were also collected on gender, pubertal development (PD), and family socio-economic status (SES). Change in HRQOL over time was evaluated using effect sizes (ES). Generalized estimating equations (GEE) were used to analyze associations among changes in KIDSCREEN scores, socio-demographic factors, and pubertal development.


Response rate at follow-up was 54% (n = 454). Overall, HRQoL worsened in eight out of the ten KIDSCREEN dimensions, with ES ranging from −0.10 (Moods and Emotions) to −0.34 (Psychological Well-being). The decrease was most marked in the intermediate age group (13–17 years of age at follow-up) and in girls. In the GEE models, pubertal development more strongly impacted changes in girls than in boys.


In this representative, population-based sample of children and adolescents, moderate decrements in HRQoL were observed after 3 years. Changes were particularly important among girls and in relation to pubertal development. These results could provide useful reference data for other longitudinal studies in population sub-groups.


Adolescents Children Health-related quality of life Longitudinal studies Pubertal Development 



Authors would specially like to thank the participating families in the KIDSCREEN follow-up study. This paper represents partial fulfillment of the requirements for the PhD program of Jorge A. Palacio Vieira at the Pompeu Fabra University (Barcelona, Spain).

Funding: Instituto de Salud Carlos III, Spanish Ministry of Health (contracts PI042504, PI042315).


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • J. A. Palacio-Vieira
    • 1
  • E. Villalonga-Olives
    • 2
    • 3
  • J. M. Valderas
    • 4
    • 2
    • 3
  • M. Espallargues
    • 1
    • 2
  • M. Herdman
    • 2
    • 3
  • S. Berra
    • 1
    • 2
  • J. Alonso
    • 3
    • 2
  • L. Rajmil
    • 1
    • 2
    • 3
    Email author
  1. 1.Catalan Agency for Health Technology Assessment and Research (CAHTA)BarcelonaSpain
  2. 2.CIBER en Epidemiología y Salud Pública (CIBERESP)BarcelonaSpain
  3. 3.Health Services Research Unit, Institut Municipal d’Investigació Mèdica (IMIM-Hospital del Mar)BarcelonaSpain
  4. 4.National Primary Care Research and Development CenterUniversity of ManchesterManchesterUK

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