Quality of Life Research

, Volume 17, Issue 9, pp 1195–1204

Personality and EQ-5D scores among individuals with chronic conditions

  • Anthony Jerant
  • Benjamin P. Chapman
  • Peter Franks



Personality is associated with self-rated health, but prior studies have not examined associations with preference-based measures. We hypothesized similar associations would exist with preference-based health.


We analyzed baseline data from chronically ill individuals enrolled in a self-management intervention. We conducted regression analyses with the EQ-5D summary index score and dimension scores (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) as dependent variables, The key independent variables were NEO-Five Factor Inventory (NEO-FFI) personality factors (Neuroticism, Conscientiousness, Extraversion, Openness, Agreeableness), adjusting for age, gender, educational level, minority status, and chronic conditions.


Of 415 participants, 245 (59%) had ≥2 chronic conditions, 384 (94%) completed the NEO-FFI and 397 (96%) the EQ-5D. After adjustment, Neuroticism was associated with EQ-5D summary index scores [−0.04 per 1 SD increase in Neuroticism (95% CI −0.06, −0.01)]. Neuroticism [AOR 2.99 (95% CI 2.06, 4.35; P < 0.001)] and Openness [1.32 (95% CI 1.00, 1.75; P = 0.05)] were associated with worse anxiety/depression scores, while Conscientiousness was associated with better usual activities scores [0.66 (95% CI 0.49, 0.89; P = 0.01)].


The associations between personality factors and self-rated health appear to extend to preference-based measures. Future studies should explore whether personality affects preference-based health estimates in cost-effectiveness analyses.


Bias Chronic disease Health status Personality Quality of life 



Chronic Disease Self-Management Program


Cost-effectiveness analysis


Center for Epidemiologic Studies Depression Scale


Confidence interval


Censored least absolute deviations


Chronic obstructive pulmonary disease


Five Factor Model


Health Assessment Questionnaire


Homing in on Health


Minimal clinically important difference


Neo-Five Factor Inventory


Ordinary least squares


Quality-adjusted life-year


Randomized controlled trial


Standard deviation


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Anthony Jerant
    • 1
  • Benjamin P. Chapman
    • 2
  • Peter Franks
    • 3
  1. 1.Department of Family & Community MedicineUniversity of California Davis School of MedicineSacramentoUSA
  2. 2.Laboratory of Personality and Development, Department of PsychiatryUniversity of Rochester Medical CenterRochesterUSA
  3. 3.Center for Healthcare Policy and Research, Department of Family & Community MedicineUniversity of California Davis School of MedicineSacramentoUSA

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