Quality of Life Research

, Volume 17, Issue 2, pp 333–345

The feasibility and responsiveness of the health utilities index in patients with early-stage breast cancer: A prospective longitudinal study

  • Peter J. Lovrics
  • Sylvie D. Cornacchi
  • Francesco Barnabi
  • Tim Whelan
  • Charles H. Goldsmith
Article

DOI: 10.1007/s11136-007-9305-2

Cite this article as:
Lovrics, P.J., Cornacchi, S.D., Barnabi, F. et al. Qual Life Res (2008) 17: 333. doi:10.1007/s11136-007-9305-2

Abstract

Background

The health utilities index (HUI3) is a health measurement instrument based on individuals’ preferences for different health states. Breast cancer (BC) is common, with a high proportion of long-term survivors, making evaluation of treatment effects important. Feasibility and responsiveness of HUI3 was compared to the short-form 36 (SF-36) in patients with BC.

Methods

HUI3 and SF-36 were administered eight times: at initial surgical consultation, 1 week before surgery; 1 week, 3, 6, 12, 18, and 24 months after surgery. Effect size, analysis of variance, and Pearson product moment correlations were calculated. BC data were compared to normative values.

Results

Eighty-five patients were enrolled. Ninety-one percent of planned assessments were completed. HUI3 showed significant responsiveness (P < 0.01) after surgery and during recovery. HUI3 scores correlated with SF-36 scores. Comparison to normative data demonstrated the significant detrimental effect of BC diagnosis. Results showed long-term effects of treatment on physical health and positive effects on mental/emotional health in BC survivors.

Conclusion(s)

HUI3 was found to be feasible and responsive in our cohort of BC patients. Changes in HUI3 values over time, and compared to normative data, paralleled SF-36 scores. HUI3 is a valuable tool in health-related quality of life and cost-utility studies in patients with BC.

Keywords

Breast cancer Health Utilities Index Quality of life Responsiveness SF-36 

Abbreviations

BC

Breast cancer

HUI3

Health utilities index

SF-36

Short form 36

HRQL

Health-related quality of life

QOL

Quality of life

ANOVA

Analysis of variance

QALYs

Quality-adjusted life years

BCS

Breast-conserving surgery

MRM

Modified radical mastectomy

PET

Positron emission tomography

IC

Initial consult

MCS

Mental component score

PCS

Physical component score

PF

Physical functioning

RP

Role-physical

BP

Bodily pain

RE

Role-emotional

MH

Mental health

GH

General health

VT

Vitality

SF

Social functioning

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Peter J. Lovrics
    • 1
    • 2
  • Sylvie D. Cornacchi
    • 1
    • 2
  • Francesco Barnabi
    • 1
  • Tim Whelan
    • 3
    • 4
  • Charles H. Goldsmith
    • 2
    • 3
    • 5
  1. 1.Department of Surgery, Hamilton Health Sciences and St. Joseph’s HealthcareMcMaster UniversityHamiltonCanada
  2. 2.Surgical Outcomes Research CentreMcMaster UniversityHamiltonCanada
  3. 3.Department of Clinical Epidemiology and BiostatisticsMcMaster UniversityHamiltonCanada
  4. 4.Department of Medicine and Supportive Cancer Care Research Unit, Juravinski Cancer Centre McMaster UniversityHamiltonCanada
  5. 5.St. Joseph’s Healthcare, Biostatistics UnitFather Sean O’Sullivan Research CentreHamiltonCanada

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