Quality of Life Research

, Volume 16, Issue 9, pp 1511–1520 | Cite as

Responsiveness of the Adult Attention-Deficit/Hyperactivity Disorder Quality of Life Scale (AAQoL)

  • Louis S. MatzaEmail author
  • Joseph A. Johnston
  • Douglas E. Faries
  • Karen G. Malley
  • Meryl Brod



This study examined responsiveness of the Adult Attention-Deficit/Hyperactivity Disorder Quality of Life Scale (AAQoL), which was developed to assess health-related quality of life (HRQL) among adults with attention-deficit/hyperactivity disorder (ADHD).


Adults with ADHD completed the AAQoL, Conners’ Adult ADHD Rating Scale (CAARS), SF-36, and Endicott Work Productivity Scale (EWPS) at baseline and week 8 of a randomized, placebo-controlled trial of atomoxetine. Clinicians rated symptom severity and improvement (CGI-ADHD-S, CGI-ADHD-I). Responsiveness was examined through effect sizes and association with change in the measures listed previously (Spearman correlations, GLMs).


Analyses included 328 patients (58.8% male; mean age = 36.9 years). All AAQoL scales reflected significant improvement from baseline to week 8 (P < 0.0001). AAQoL change scores were significantly correlated with change in the CGI-ADHD-S (r = −0.37 to −0.50), EWPS (r = −0.43 to −0.63), and CAARS (r = −0.35 to −0.62) (all P < 0.001). AAQoL change scores significantly discriminated among patients with various levels of symptom improvement. AAQoL effect sizes (−0.67 to −1.11) were larger than effect sizes for the SF-36 (0.15 to −0.39).


The AAQoL was responsive to change in symptoms of ADHD, and it appears to be a useful outcome measure for treatments of ADHD in adults.


AAQoL ADHD Attention-deficit hyperactivity disorder Health-related quality of life Responsiveness 



Adult ADHD Quality of Life Measure


Attention-deficit hyperactivity disorder


Clinical Global Impressions-ADHD Improvement


Clinical Global Impressions-ADHD Severity


Conners’ Adult ADHD Diagnostic Interview for DSM-IV


Conners’ Adult Attention-Deficit/Hyperactivity Disorder Rating Scale-Self Report: Screening Version


Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Text Revision


Endicott Work Productivity Scale


General linear models


Health-related quality of life


Medical Outcomes Study 36-Item Short Form Health Survey


Minimally important difference


Standard error of measurement



The authors thank Karin Coyne for psychometric consultation as well as Jodi Shorr and Julie Meilak for production assistance. This study was funded by Eli Lilly and Company.


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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Louis S. Matza
    • 1
    Email author
  • Joseph A. Johnston
    • 2
  • Douglas E. Faries
    • 2
  • Karen G. Malley
    • 3
  • Meryl Brod
    • 4
  1. 1.Center for Health Outcomes Research at UBCBethesdaUSA
  2. 2.Eli Lilly & CompanyIndianapolisUSA
  3. 3.Malley Research Programming, Inc.RockvilleUSA
  4. 4.The Brod GroupMill ValleyUSA

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