Responsiveness of the Adult Attention-Deficit/Hyperactivity Disorder Quality of Life Scale (AAQoL)
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This study examined responsiveness of the Adult Attention-Deficit/Hyperactivity Disorder Quality of Life Scale (AAQoL), which was developed to assess health-related quality of life (HRQL) among adults with attention-deficit/hyperactivity disorder (ADHD).
Adults with ADHD completed the AAQoL, Conners’ Adult ADHD Rating Scale (CAARS), SF-36, and Endicott Work Productivity Scale (EWPS) at baseline and week 8 of a randomized, placebo-controlled trial of atomoxetine. Clinicians rated symptom severity and improvement (CGI-ADHD-S, CGI-ADHD-I). Responsiveness was examined through effect sizes and association with change in the measures listed previously (Spearman correlations, GLMs).
Analyses included 328 patients (58.8% male; mean age = 36.9 years). All AAQoL scales reflected significant improvement from baseline to week 8 (P < 0.0001). AAQoL change scores were significantly correlated with change in the CGI-ADHD-S (r = −0.37 to −0.50), EWPS (r = −0.43 to −0.63), and CAARS (r = −0.35 to −0.62) (all P < 0.001). AAQoL change scores significantly discriminated among patients with various levels of symptom improvement. AAQoL effect sizes (−0.67 to −1.11) were larger than effect sizes for the SF-36 (0.15 to −0.39).
The AAQoL was responsive to change in symptoms of ADHD, and it appears to be a useful outcome measure for treatments of ADHD in adults.
KeywordsAAQoL ADHD Attention-deficit hyperactivity disorder Health-related quality of life Responsiveness
Adult ADHD Quality of Life Measure
Attention-deficit hyperactivity disorder
Clinical Global Impressions-ADHD Improvement
Clinical Global Impressions-ADHD Severity
Conners’ Adult ADHD Diagnostic Interview for DSM-IV
Conners’ Adult Attention-Deficit/Hyperactivity Disorder Rating Scale-Self Report: Screening Version
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Text Revision
Endicott Work Productivity Scale
General linear models
Health-related quality of life
Medical Outcomes Study 36-Item Short Form Health Survey
Minimally important difference
Standard error of measurement
The authors thank Karin Coyne for psychometric consultation as well as Jodi Shorr and Julie Meilak for production assistance. This study was funded by Eli Lilly and Company.
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