Factors associated with health-related quality of life among hemodialysis patients in the DOPPS
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To identify modifiable factors associated with health-related quality of life (HRQOL) among chronic hemodialysis patients.
Analysis of baseline data of 9,526 hemodialysis patients from seven countries enrolled in phase I of the Dialysis Outcomes and Practice Patterns Study (DOPPS). Using the Kidney Disease Quality of Life Short Form (KDQOL-SFTM), we determined scores for 8 generic scale summaries derived from these scales, i.e., the physical component summary [PCS] and mental component summary [MCS], and 11 kidney disease-targeted scales. Regression models were used to adjust for differences in comorbidities and sociodemographic and treatment factors. The Benjamin-Hochberg procedure was used to correct P-values for multiple comparisons.
Unemployment and psychiatric disease were independently and significantly associated with lower scores for all generic and several kidney disease-targeted HRQOL measures. Several other comorbidities, lower educational level, lower income, and hypoalbuminemia were also independently and significantly associated with lower scores of PCS and/or MCS and several generic and kidney disease-targeted scales. Hemodialysis by catheter was associated with significantly lower PCS scores, partially explained by the correlation with covariates.
Associations of poorer HRQOL with preventable or controllable factors support a greater focus on psychosocial and medical interventions to improve the well-being of hemodialysis patients.
KeywordsDOPPS End-stage renal disease (ESRD) Hemodialysis KDQOL-SF Outcomes
Health-related quality of life
Dialysis Outcomes and Practice Patterns Study
Kidney Disease Quality of Life Short Form
Physical Component Summaries
Mental Component Summaries
End-stage renal disease
Short-Form Health Survey
Systolic blood pressure
Normalized protein catabolic rate
Body Mass Index
Adjusted difference in score
Equilibrated Kt/V (dialysis dose)
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