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Burden of restless legs syndrome on health-related quality of life

  • Clete Kushida
  • Marie Martin
  • Prashant Nikam
  • Bonnie Blaisdell
  • Gene WallensteinEmail author
  • Luigi Ferini-Strambi
  • John E. WareJr
Original Paper

Abstract

Objective

To quantify the total and unique burden of Restless Legs Syndrome (RLS) on patient-reported health-related quality of life (HRQoL).

Methods

The disease burden that RLS places on HRQoL was estimated by comparing Short-Form (SF-36) scores between individuals with RLS and several patient and general populations in the US. Regression methods were applied to estimate SF-36 normative values from the general population sample and statistically adjust them to match age, gender and disease comorbidity characteristics of the RLS sample. Significance tests were then used to compare the means across samples.

Results

All SF-36 measures were significantly below adjusted US general population norms. Five of the eight scales (physical functioning, role physical, bodily pain, general health, vitality) were below US norms by 0.8 or more standard deviations (SD), while the remaining three (social functioning, role emotional, mental health) were 0.5 SD below norm. The burden of RLS was greater on physical than on mental/emotional HRQoL (physical and mental summary scores were 1.08 and 0.40 SD below norm, respectively), and greater than that observed for type-2 diabetes.

Conclusion

After controlling for the impact of age, gender, and disease comorbidity, RLS was associated with unique burden on both physical and mental aspects of HRQoL.

Keywords

Burden of illness Restless legs syndrome Quality of life 

Abbreviations

HRQoL

Health-related quality of life

IRLSSG

International Restless Legs Syndrome Study Group

OA

Osteoarthritis

QoL

Quality of life

RLS

Restless legs syndrome

SF-36

Short-Form 36

SD

Standard deviation

Notes

Acknowledgment

This study was supported by a grant from GlaxoSmithKline that covered costs associated with the design of the study; collection, management, analysis, and interpretation of the data; and preparation, review, and approval of the manuscript.

References

  1. 1.
    Aalto A. M., Uutela A., Aro A. R. (1997). Health related quality of life among insulin-dependent diabetics: disease-related and psychosocial correlates. Patient Education Counselling, 30, 215–25CrossRefGoogle Scholar
  2. 2.
    Abetz L., Allen R., Follet A., Washburn T., Earley C., Kirsch J. (2004). Evaluating the quality of life of patients with restless legs syndrome. Clinical Therapeutics, 26, 925–35CrossRefPubMedGoogle Scholar
  3. 3.
    Allen R. P., Earley C. J. (2001). Restless legs syndrome: a review of clinical and pathophysiologic features. Journal of Clinical Neurophysiology, 18, 128–47CrossRefPubMedGoogle Scholar
  4. 4.
    Allen R. P., Picchietti D., Hening W. A., Trenkwalder C., Walters A. S., Montplaisir J. (2003). Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the Institutes of Health. Sleep Medicine, 4, 101–19CrossRefPubMedGoogle Scholar
  5. 5.
    Allen R. P., Walters A. S., Montplasir J., Hening W., Myers A., Bell T. J., Ferini-Strambi L. (2005). Restless legs syndrome prevalence and impact: REST general population study. Archives of Internal Medicine, 165, 1286–292CrossRefPubMedGoogle Scholar
  6. 6.
    Berwick D. M., Murphy J. M., Goldman P. A., Ware J. E. Jr, Barsky A. J., Weinstein M. C. (1991). Performance of a five-item mental health screening test. Medical Care, 29, 169–76CrossRefPubMedGoogle Scholar
  7. 7.
    Earley C. J. (2003). Clinical practice. Restless legs syndrome. New England Journal of Medicine, 348, 2103–109CrossRefPubMedGoogle Scholar
  8. 8.
    Hening W. (2004). The clinical neurophysiology of the restless legs syndrome and periodic limb movements. Part I: diagnosis, assessment, and characterization. Clinical Neurophysiology, 115, 1965–974CrossRefPubMedGoogle Scholar
  9. 9.
    Hening W., Allen R., Earley C., Kushida C., Picchietti D., Silber M. (1999). The treatment of restless legs syndrome and periodic limb movement disorder. An American academy of sleep medicine review. Sleep, 22, 970–99PubMedGoogle Scholar
  10. 10.
    Hening W., Walters A. S., Allen R. P., Montplaisir J., Myers A., Ferini-Strambi L. (2004). Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Medicine, 5, 237–46CrossRefPubMedGoogle Scholar
  11. 11.
    Kravitz R. L., Greenfield S., Rogers W., Manning W. G. Jr, Zubkoff M., Nelson E. C. (1992). Differences in the mix of patients among medical specialities and systems of care. Results from the medical outcomes study. JAMA, 267, 1617–623CrossRefPubMedGoogle Scholar
  12. 12.
    Kushida C. A., Allen R. P., Atkinson M. J. (2004). Modeling the causal relationships between symptoms associated with restless legs syndrome and the patient-reported impact of RLS. Sleep Medicine, 5, 485–88CrossRefPubMedGoogle Scholar
  13. 13.
    Milligan S. A., Chesson A. L. (2002). Restless legs syndrome in the older adult: diagnosis and management. Drugs & Aging, 19, 741–51CrossRefGoogle Scholar
  14. 14.
    National Center on Sleep Disorders Research. (2000) National Institutes of Health. Restless Legs Syndrome: Detection and Management in Primary Care (NIH Pub. No. 00-3788). Bethesda, MDGoogle Scholar
  15. 15.
    Phillips B., Young T., Finn L., Asher K., Hening W. A. (2000). Purvis C. Epidemiology of restless legs syndrome in adults. Archives of Internal Medicine, 160, 2137–141CrossRefPubMedGoogle Scholar
  16. 16.
    Rothdach A. J., Trenkwalder C., Haberstock J., Keil U., Berger K. (2000). Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and morbidity in ausburg elderly. Neurology, 54, 1064–068PubMedGoogle Scholar
  17. 17.
    Ware J. E. Jr, Gandek B. (1998). Methods for testing data quality, scaling assumptions, and reliability: the IQOLA Project approach. International quality of life assessment. Journal of Clinical Epidemiology, 51, 945–52CrossRefPubMedGoogle Scholar
  18. 18.
    Ware J. E., Harris W. J., Gandek B., Rogers B. W., Reese P. R. (1997). MAP-R for Windows: Multitrait/multi-item analysis program –revised user’s guide. Boston, MA: Health Assessment LabGoogle Scholar
  19. 19.
    Ware J. E. Jr, Kosinski M. (2001) SF-36 Physical & mental health summary scales: A manual for users of version 1. (2nd ed.). Lincoln, RI: QualityMetric IncorporatedGoogle Scholar
  20. 20.
    Ware J. E. Jr, Kosinski M., Gandek B. (2000) SF-36 Health survey: Manual & interpretation guide. Lincoln, R. I.: QualityMetric IncorporatedGoogle Scholar
  21. 21.
    Ware J. E. Jr, Sherbourne C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30, 473–83CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Clete Kushida
    • 1
  • Marie Martin
    • 2
  • Prashant Nikam
    • 3
  • Bonnie Blaisdell
    • 2
  • Gene Wallenstein
    • 2
    Email author
  • Luigi Ferini-Strambi
    • 4
  • John E. WareJr
    • 2
    • 5
  1. 1.Stanford Center of Excellence for Sleep DisordersStanfordUSA
  2. 2.QualityMetric IncorporatedLincolnUSA
  3. 3.GlaxoSmithKlineCollegevilleUSA
  4. 4.Department of NeurosciencesUniversità Vita-Salute San RaffaeleMilanItaly
  5. 5.Health Assessment LabWalthamUSA

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