Burden of restless legs syndrome on health-related quality of life
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To quantify the total and unique burden of Restless Legs Syndrome (RLS) on patient-reported health-related quality of life (HRQoL).
The disease burden that RLS places on HRQoL was estimated by comparing Short-Form (SF-36) scores between individuals with RLS and several patient and general populations in the US. Regression methods were applied to estimate SF-36 normative values from the general population sample and statistically adjust them to match age, gender and disease comorbidity characteristics of the RLS sample. Significance tests were then used to compare the means across samples.
All SF-36 measures were significantly below adjusted US general population norms. Five of the eight scales (physical functioning, role physical, bodily pain, general health, vitality) were below US norms by 0.8 or more standard deviations (SD), while the remaining three (social functioning, role emotional, mental health) were 0.5 SD below norm. The burden of RLS was greater on physical than on mental/emotional HRQoL (physical and mental summary scores were 1.08 and 0.40 SD below norm, respectively), and greater than that observed for type-2 diabetes.
After controlling for the impact of age, gender, and disease comorbidity, RLS was associated with unique burden on both physical and mental aspects of HRQoL.
KeywordsBurden of illness Restless legs syndrome Quality of life
Health-related quality of life
International Restless Legs Syndrome Study Group
Quality of life
Restless legs syndrome
This study was supported by a grant from GlaxoSmithKline that covered costs associated with the design of the study; collection, management, analysis, and interpretation of the data; and preparation, review, and approval of the manuscript.
- 4.Allen R. P., Picchietti D., Hening W. A., Trenkwalder C., Walters A. S., Montplaisir J. (2003). Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the Institutes of Health. Sleep Medicine, 4, 101–19CrossRefPubMedGoogle Scholar
- 10.Hening W., Walters A. S., Allen R. P., Montplaisir J., Myers A., Ferini-Strambi L. (2004). Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Medicine, 5, 237–46CrossRefPubMedGoogle Scholar
- 14.National Center on Sleep Disorders Research. (2000) National Institutes of Health. Restless Legs Syndrome: Detection and Management in Primary Care (NIH Pub. No. 00-3788). Bethesda, MDGoogle Scholar
- 18.Ware J. E., Harris W. J., Gandek B., Rogers B. W., Reese P. R. (1997). MAP-R for Windows: Multitrait/multi-item analysis program –revised user’s guide. Boston, MA: Health Assessment LabGoogle Scholar
- 19.Ware J. E. Jr, Kosinski M. (2001) SF-36 Physical & mental health summary scales: A manual for users of version 1. (2nd ed.). Lincoln, RI: QualityMetric IncorporatedGoogle Scholar
- 20.Ware J. E. Jr, Kosinski M., Gandek B. (2000) SF-36 Health survey: Manual & interpretation guide. Lincoln, R. I.: QualityMetric IncorporatedGoogle Scholar