Quality of Life Research

, 16:617

Burden of restless legs syndrome on health-related quality of life

  • Clete Kushida
  • Marie Martin
  • Prashant Nikam
  • Bonnie Blaisdell
  • Gene Wallenstein
  • Luigi Ferini-Strambi
  • John E. WareJr
Original Paper

DOI: 10.1007/s11136-006-9142-8

Cite this article as:
Kushida, C., Martin, M., Nikam, P. et al. Qual Life Res (2007) 16: 617. doi:10.1007/s11136-006-9142-8

Abstract

Objective

To quantify the total and unique burden of Restless Legs Syndrome (RLS) on patient-reported health-related quality of life (HRQoL).

Methods

The disease burden that RLS places on HRQoL was estimated by comparing Short-Form (SF-36) scores between individuals with RLS and several patient and general populations in the US. Regression methods were applied to estimate SF-36 normative values from the general population sample and statistically adjust them to match age, gender and disease comorbidity characteristics of the RLS sample. Significance tests were then used to compare the means across samples.

Results

All SF-36 measures were significantly below adjusted US general population norms. Five of the eight scales (physical functioning, role physical, bodily pain, general health, vitality) were below US norms by 0.8 or more standard deviations (SD), while the remaining three (social functioning, role emotional, mental health) were 0.5 SD below norm. The burden of RLS was greater on physical than on mental/emotional HRQoL (physical and mental summary scores were 1.08 and 0.40 SD below norm, respectively), and greater than that observed for type-2 diabetes.

Conclusion

After controlling for the impact of age, gender, and disease comorbidity, RLS was associated with unique burden on both physical and mental aspects of HRQoL.

Keywords

Burden of illness Restless legs syndrome Quality of life 

Abbreviations

HRQoL

Health-related quality of life

IRLSSG

International Restless Legs Syndrome Study Group

OA

Osteoarthritis

QoL

Quality of life

RLS

Restless legs syndrome

SF-36

Short-Form 36

SD

Standard deviation

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Clete Kushida
    • 1
  • Marie Martin
    • 2
  • Prashant Nikam
    • 3
  • Bonnie Blaisdell
    • 2
  • Gene Wallenstein
    • 2
  • Luigi Ferini-Strambi
    • 4
  • John E. WareJr
    • 2
    • 5
  1. 1.Stanford Center of Excellence for Sleep DisordersStanfordUSA
  2. 2.QualityMetric IncorporatedLincolnUSA
  3. 3.GlaxoSmithKlineCollegevilleUSA
  4. 4.Department of NeurosciencesUniversità Vita-Salute San RaffaeleMilanItaly
  5. 5.Health Assessment LabWalthamUSA

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