Quality of Life Research

, Volume 16, Issue 2, pp 331–343 | Cite as

The development of a new measure of quality of life in the management of gastro-oesophageal reflux disease: the Reflux questionnaire

  • Susan Macran
  • Samantha Wileman
  • Garry Barton
  • Ian Russell
  • for the REFLUX trial group
OriginalPaper

Abstract

Introduction

This paper reports on the development of a new measure of health-related quality of life for use among patients with gastro-oesophageal reflux disease (GORD), funded as part of the REFLUX trial. This is a large UK multi centre trial that aims to compare the clinical and cost effectiveness of minimal access surgery with best medical treatment for patients with GORD within the NHS.

Method

Potential items were identified via a series of interviews and focus groups carried out with patients who were receiving/had received medical or surgical treatment for GORD. The final measure consisted of 31 items covering 7 categories (Heartburn; Acid reflux; Wind; Eating and swallowing; Bowel movements; Sleep; Work, physical and social activities). The measure produced two outputs: a quality of life score (RQLS) and five Reflux symptom scores. Reliability (internal consistency), criterion validity with the SF-36 and, sensitivity to change in terms of relationship with reported change in prescribed medication were assessed amongst a sample of 794 patients recruited into the trial.

Results

The measure was shown to be internally consistent, to show criterion validity with the SF-36 and sensitive to changes in patients use of prescribed medication at baseline and 3 month follow-up.

Discussion

The Reflux questionnaire is a new self-administered questionnaire for use amongst patients with GORD. Initial findings suggest that the new measure is valid, reliable, acceptable to respondents and simple to administer in both a clinical and research context.

Keywords

Gastro-oesophageal reflux disease Quality of life Scale development 

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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Susan Macran
    • 1
  • Samantha Wileman
    • 2
  • Garry Barton
    • 3
  • Ian Russell
    • 4
  • for the REFLUX trial group
    • 1
  1. 1.Outcomes Research Group, Centre for Health EconomicsUniversity of YorkHeslington, YorkUnited Kingdom
  2. 2.Health Services Research Unit, University of AberdeenAberdeenUK
  3. 3.School of Economics, University of NottinghamNottinghamUK
  4. 4.Institute of Medical & Social Care ResearchUniversity of WalesBangorUK

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