Quality of Life Research

, Volume 15, Issue 10, pp 1565–1570 | Cite as

Associations of Functional Status and Depressive Symptoms with Health-related Quality of Life in Cancer Patients

  • M. PinquartEmail author
  • A. Koch
  • B. Eberhardt
  • C. Brix
  • U. Wedding
  • B. Röhrig
Original Paper


Associations of functional status (as measured with the Karnofsky Index), depressive symptoms (as assessed with the Beck Depression Inventory), and sociodemographic characteristics with health-related quality of life (HrQoL; measured with the EORTC Quality of Life Questionnaire QLQ-C30) were assessed in 170 recently diagnosed cancer patients. A better functional status (p<0.001) and a lower level of depressive symptoms (p<0.001) were associated with better HrQoL. In addition, an interaction effect of functional status with HrQoL was found (p<0.001), indicating that stronger functional impairments were related to lower HrQoL in patients with low and average levels of depressive symptoms, but not in those with high levels of depressive symptoms. Associations of HrQoL with sociodemographic variables were not significant. It is concluded that functional decline does not additionally impair HrQoL when patients already have elevated levels of depressive symptoms.


Cancer Depression Functional status Health-related quality of life Oncology 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • M. Pinquart
    • 1
    Email author
  • A. Koch
    • 2
  • B. Eberhardt
    • 3
  • C. Brix
    • 4
  • U. Wedding
    • 5
  • B. Röhrig
    • 5
  1. 1.Department of Developmental Psychology and Center for Applied Developmental ScienceFriedrich Schiller UniversityJenaGermany
  2. 2.Hospital of PsychiatryFriedrich Schiller UniversityJenaGermany
  3. 3.Department of Biological and Clinical PsychologyFriedrich Schiller UniversityJenaGermany
  4. 4.Department of Medical PsychologyFriedrich Schiller UniversityJenaGermany
  5. 5.Hospital of Internal Medicine IIFriedrich Schiller UniversityJenaGermany

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