Quality of Life Research

, Volume 15, Issue 9, pp 1439–1446 | Cite as

Evaluating Function and Health Related Quality of Life in Patients Treated for Extremity Soft Tissue Sarcoma

  • Daphne Schreiber
  • Robert S. Bell
  • Jay S. Wunder
  • Brian O’Sullivan
  • Robert Turcotte
  • Bassam A. Masri
  • Aileen M. DavisEmail author
Original Paper



To evaluate how functional disability impacts on health related quality of life (HRQOL) of patients with extremity soft tissue sarcoma (STS) at 1 year post-surgery.

Design and setting

Survey of extremity STS patients pre-surgery and one-year post-treatment.


100 participants who were treated for extremity STS between 2001 and 2003 at four Canadian hospitals. Patients were over 16 years, non-metastatic at diagnosis, and had limb salvage surgery.

Outcome measures

Musculoskeletal Tumor Society Rating Scale (MSTS), a measure of impairment; Toronto Extremity Salvage Score (TESS), a measure of activity limitations; Reintegration to Normal Living Index (RNL), a measure of participation restrictions; and EQ-VAS, a measure of HRQOL.


After adjusting for demographic and clinical variables, impairment explained 54%, activity limitations explained 48%, and participation restrictions explained 61% of the variation in HRQOL. After adjustment, when all three functional measures were included in the model, only participation restrictions had a significant impact on HRQOL explaining 63% of the variation.


Impairment and activity limitations affect the daily activities a patient can perform, but it is the restriction in participation of life roles and situations that has the greatest effect on patient’s HRQOL.

Key words

Cancer rehabilitation Disability evaluation Quality of life Sarcoma 



American joint committee on cancer


health related quality of life


international classification of function


life orientation test


musculoskeletal tumor society rating scale


reintegration to normal living index


soft tissue sarcoma


Toronto extremity salvage score


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Copyright information

© Springer 2006

Authors and Affiliations

  • Daphne Schreiber
    • 1
  • Robert S. Bell
    • 2
    • 3
    • 4
    • 5
  • Jay S. Wunder
    • 2
    • 4
  • Brian O’Sullivan
    • 4
    • 6
  • Robert Turcotte
    • 7
  • Bassam A. Masri
    • 8
  • Aileen M. Davis
    • 1
    • 4
    • 9
    Email author
  1. 1.Division of Outcomes and Population HealthToronto Western Research InstituteTorontoCanada
  2. 2.Division of OrthopaedicsMount Sinai HospitalTorontoCanada
  3. 3.Department of Surgical OncologyPrincess Margaret HospitalTorontoCanada
  4. 4.University of TorontoTorontoCanada
  5. 5.University Health NetworkTorontoCanada
  6. 6.Department of Radiation OncologyPrincess Margaret HospitalTorontoCanada
  7. 7.Division of Orthopaedic SurgeryMcGill UniversityMontrealCanada
  8. 8.BC Cancer Agency and University of British ColumbiaVancouverCanada
  9. 9.Division of Outcomes and Population HealthToronto Western Research InstituteTorontoCanada

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