Quality of Life Research

, Volume 15, Issue 3, pp 481–491 | Cite as

Measuring the Impact of Diabetes Through Patient Report of Treatment Satisfaction, Productivity and Symptom Experience

  • Meryl Brod
  • Soren E. Skovlund
  • Kim U. Wittrup-Jensen
Article

Abstract

Objective: Diabetes is a common, debilitating chronic illness with multiple impacts. The impact on treatment satisfaction, productivity impairment and the symptom experience may be among the most important for patient-reported outcomes. This study developed and validated disease-specific, patient-reported measures for these outcomes that address limitations in currently available measures. Methods: Data was collected from the literature, experts and patients and a conceptual model of the patient-reported impact of diabetes was created. Item pools, based on the conceptual model, were then generated. The items were administered to 991 diabetes patients via a web-based survey to perform item reduction, identify relevant factor structures and assess reliability and validity following an a-priori analysis plan. Results: All validation criteria and hypotheses were met resulting in three new, valid measures: a 21-item Satisfaction Measure (three sub-scales: burden, efficacy and symptoms), a 30-item Symptom Measure and a 14-item Productivity Measure assessing both life and work productivity impairments.Conclusion: This triad of measures captures important components of the multifaceted diabetes patient experience and can be considered as valid, viable options when choosing measures to assess patient-reported outcomes. Addressing these outcomes may assist researchers and clinicians to develop more patient-centered diabetes interventions and care.

Keywords

Diabetes Patient-reported outcomes Productivity Symptoms Treatment satisfaction 

Abbreviations

DPM

Diabetes Productivity Measure

DSM

Diabetes Symptom Measure

ITAS

Insulin Treatment Appraisal Scale

MCID

Minimal Clinically Important Difference

OLS

Ordinary Least Squares

PAID

Problem Areas in Diabetes Survey

PRO

Patient-Reported Outcomes

SAP

Statistical Analysis Plan

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References

  1. 1.
    Zimmet, P, Alberti, KG, Shaw, J 2001Global and societal implications of the diabetes epidemicNature414782787CrossRefPubMedGoogle Scholar
  2. 2.
    King, H, Aubert, RE, Herman, WH 1998Global burden of diabetes, 1995–2025: Prevalence, numerical estimates, and projectionsDiabetes Care2114141431PubMedGoogle Scholar
  3. 3.
    Sonnaville, JJ , Snoek, FJ, Colly, LP, Deville, W, Wijkel, D, Heine, RJ 1998Well-being and symptoms in relation to insulin therapy in type 2 diabetesDiabetes Care21919924PubMedGoogle Scholar
  4. 4.
    Grauw, WJ , Lisdonk, EH, Behr, RR, Gerwen, WH, Hoogen, HJ, Weel, C 1999The impact of type 2 diabetes mellitus on daily functioningFam Pract16133139PubMedGoogle Scholar
  5. 5.
    Cramer, JA 2004A systematic review of adherence with medications for diabetesDiabetes Care2712181224PubMedGoogle Scholar
  6. 6.
    Snoek, FJ 2000Barriers to good glycaemic control: the patient’s perspectiveInt J Obes Relat Metab Disord24S12S20ReviewPubMedGoogle Scholar
  7. 7.
    Alberti, G 2002The DAWN (Diabetes Attitudes Wishes and Needs) studyPract Diabetes Int1922249Google Scholar
  8. 8.
    Albrecht, G, Hoogstraten, J 1998Satisfaction as determination of complianceCommun Dent Oral Epidemiol26139146Google Scholar
  9. 9.
    Anderson, RT, Marrero, D, Skovlund, SE, Cramer, J, Schwartz, S 2003Self-reported compliance with insulin injection therapy in subjects with type 1 and 2 diabetesDiabetologia46A275Google Scholar
  10. 10.
    Brody, DS, Miller, SM, Lerman, CE, Smith, DG, Caputo, GC 1989Patient perception of involvement in medical care: relationship to illness attitudes and outcomesJ Gen Intern Med4506511PubMedGoogle Scholar
  11. 11.
    Taylor, TR 2000Understanding the choices that patients makeJ Am Board Fam Pract13124133PubMedGoogle Scholar
  12. 12.
    McCracken, LM, Klock, PA, Mingay, DJ, Asbury, JK, Sinclair, DM 1997Assessment of satisfaction with treatment for chronic painJ Pain Symptom Manage14292299CrossRefPubMedGoogle Scholar
  13. 13.
    Cappelleri, JC, Gerber, RA, Kourides, IA, Gelfand, RA 2000Development and factor analysis of a questionnaire to measure patient satisfaction with injected and inhaled insulin for type 1 diabetesDiabetes Care2317991803PubMedGoogle Scholar
  14. 14.
    Peyrot, M, Rubin, RR 2005Validity and reliability of an instrument for assessing health-related quality of life and treatment preferenceDiabetes Care285358PubMedGoogle Scholar
  15. 15.
    Anderson, RT, Skovlund, SE, Marrero, D,  et al. 2004Development and validation of the insulin treatment satisfaction questionnaireClin Ther26565578CrossRefPubMedGoogle Scholar
  16. 16.
    Colman, SS, Brod, M, Potter, LP, Buesching, DP, Rowland, CR 2004Cross-sectional 7-year follow-up of anxiety in primary care patientsDepress Anxiety19105111CrossRefPubMedGoogle Scholar
  17. 17.
    Mayfield, JA, Deb, P, Whitecotton, L 1999Work disability and diabetesDiabetes Care2211051109PubMedGoogle Scholar
  18. 18.
    Ramsey, S, Summers, KH, Leong, SA, Birnbaum, HG, Kemner, JE, Greenberg, P. 2002Productivity and medical costs of diabetes in a large employer populationDiabetes Care252329PubMedGoogle Scholar
  19. 19.
    Weijman, I, Ros, WJ, Rutten, GE, Schaufeli, WB, Schabracq, MJ, Winnubst, JA 2003Fatigue in employees with diabetes: Its relation with work characteristics and diabetes related burdenOccup Environ Med60i93i98PubMedGoogle Scholar
  20. 20.
    Grootenhuis, PA, Snoek, FJ, Heine, RJ, Bouter, LM 1994Development of a type 2 diabetes symptom checklist: a measure of symptom severityDiabet Med11253261PubMedGoogle Scholar
  21. 21.
    Ciechanowski, PS, Katon, WJ, Russo, JE, Hirsch, IB 2003The relationship of depressive symptoms to symptom reporting, self-care and glucose control in diabetesGen Hosp Psychiatry25246252CrossRefPubMedGoogle Scholar
  22. 22.
    Rubin, RR, Peyrot, M 1999Quality of life and diabetesDiabetes Metab Res Rev15205218. ReviewCrossRefPubMedGoogle Scholar
  23. 23.
    Watkins, K, Connell, CM 2004Measurement of Health-Related QoL in Diabetes MellitusPharmacoeconomics2211091126CrossRefPubMedGoogle Scholar
  24. 24.
    Acquadro, C, Berzon, R, Ddubois, D, Leidy, NK, Marquis, P, Revicki, D, Rothman, M 2003Incorporating the Patient’s Perspective into Drug Development and Communication: An Ad Hoc Task Force Report of the Patient Reported Outcomes (PRO) Harmonization Group Meeting at the Food and Drug Administration, February 16,2001Value Health6522531CrossRefPubMedGoogle Scholar
  25. 25.
    Skovlund, S, NCW, vander, Pouwer, F, Snoek, FJ 2003Appraisal of insulin therapy among type 2 diabetes patients with and without previous experience of insulin treatmentDiabetes52A419Google Scholar
  26. 26.
    Polonsky, WH, Anderson, BJ, Lohrer, PA, Welch, G, Jacobson, AM, Aponte, JE, Schwartz, CE 1995Assessment of diabetes-related distressDiabetes Care18754760PubMedGoogle Scholar
  27. 27.
    Koopman, C, Pelletier, KR, Murray, JF, Sharda, CE, Berger, ML, Turpin, RS, Hackleman, P, Gibson, P, Holmes, DM, Bendel, T 2002Stanford presenteeism scale: health status and employee productivityJ Occup Environ Med441420PubMedGoogle Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  • Meryl Brod
    • 1
  • Soren E. Skovlund
    • 2
  • Kim U. Wittrup-Jensen
    • 2
  1. 1.The BROD GROUPMill ValleyUSA
  2. 2.Novo NordiskBagsvaerdDenmark

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