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Quality of Life Research

, Volume 14, Issue 2, pp 329–347 | Cite as

The quality of life impact of acute exacerbations of chronic bronchitis (AECB): A literature review

  • Jordana K. SchmierEmail author
  • Michael T. Halpern
  • Mitchell K. Higashi
  • Alan Bakst
Article

Abstract

Background: The impact of acute exacerbations of chronic bronchitis (AECB), a common consequence of chronic obstructive pulmonary disease (COPD), is extensive, with symptoms ranging from mild to life threatening. Health-related quality of life (HRQL) is impaired in patients with COPD, but little is known about the direct effect of exacerbations on HRQL. Methods: MEDLINE and EMBASE literature searches were conducted; reference lists of identified articles were reviewed. Results: Eighteen studies reporting the impact on HRQL of acute exacerbations were identified. Study design and patient population varied. Six studies evaluated HRQL once; only four studies used both generic and disease-specific HRQL measures. Cross-sectional studies reported HRQL decrements during exacerbations and suggested that HRQL is a good predictor of health care resource utilization. Pharmacological treatment led to within-group improvements following AECBs. Non-pharmacological intervention studies were small and inconclusive. Longitudinal studies, assessing pharmacological and non-pharmacological interventions, found that HRQL improved from exacerbation to recovery, with responsiveness depending on sensitivity of the measure. Frequency of exacerbations was a significant predictor of HRQL. Conclusions: Exacerbations lead to substantial reductions in HRQL, both in physical as well as other domains. Further research should assess the impact of specific treatment regimens and the timeline for the recovery process.

Keywords

Bacterial infections Chronic bronchitis Chronic obstructive pulmonary disease Exacerbations Quality of life 

Abbreviations

AECB

acute exacerbation(s) of chronic bronchitis

AUC

area under the curve

COPD

chronic obstructive pulmonary disease

CRQ

chronic respiratory disease questionnaire

FEV1

forced expiratory volume in 1 s

HRQL

health-related quality of life

HUI

health utilities index

LTOT

long-term oxygen therapy

MYMOP

measure yourself medical outcomes profile

NHP

Nottingham health profile

PGWB

psychological general well-being scale

SF-36

short form 36

SIP

sickness impact profile

SGRQ

St George’s respiratory questionnaire

SOLDQ

Seattle obstructive lung disease questionnaire

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Copyright information

© Springer 2005

Authors and Affiliations

  • Jordana K. Schmier
    • 1
    Email author
  • Michael T. Halpern
    • 1
  • Mitchell K. Higashi
    • 2
  • Alan Bakst
    • 2
  1. 1.ExponentAlexandriaUSA
  2. 2.GlaxoSmithKlineCollegevilleUSA

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