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Hypoglycemic and Vasorelaxant Effect of Passiflora edulis Fruit Peel By-Product

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Abstract

Passiflora edulis fo. flavicarpa (Passifloraceae) is popularly known as yellow passion fruit and its fruit peels are considered a rich by-product in bioactive compounds which has greatly beneficial health properties. The objective of this study was to evaluate the effects of P. edulis fruit peel extracts in a type 1 diabetes model and the potential vasorelaxant effect. The aqueous and hydroethanolic extracts were obtained from P. edulis fruit peels and orientin and isorientin flavonoids were identified in both extracts through ultra-high performance liquid chromatography. Pectin was only identified in the aqueous extract by high-performance steric exclusion chromatography and nuclear magnetic resonance. Regarding the vascular system, the hydroethanolic extract showed better vasorelaxant effects in the mesenteric artery rings when compared to the aqueous extract. These effects mainly occur by opening the potassium channels. In the type 1 diabetes model, extracts at doses of 400 and 600 mg/kg were able to restore the effect of insulin in diabetic rats which were not responding to its action. The antidiabetic effect was more significant for the aqueous extract. Thus, the results suggest that the hydroethanolic and aqueous extracts have greater potential to be used to treat cardiovascular diseases such as hypertension and as a hypoglycemic agent, respectively. Taken together, P. edulis fruit peel extracts proved to be a source of valuable bioactive raw material to produce nutraceuticals or pharmaceutical products.

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Data Availability

All data generated or analyzed during this study are included in this published article and its supplementary information files.

References

  1. Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, Branco IR, Caulfield MJ, Deanfield JE, Smeeth L, Williams B, Hingorani A, Hemingway H (2014) Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years llost, and age-specific associations in 1.25 million people. Lancet 383:1899–1911

    Article  Google Scholar 

  2. Pálsson R, Patel UD (2014) Cardiovascular complications of diabetic kidney disease. Adv Chronic Kidney Dis 21:273–280

    Article  Google Scholar 

  3. MacLean CD, Littenberg B, Kennedy AG (2006) Limitations of diabetes pharmacotherapy: results from the Vermont Diabetes Information System Study. BMC Fam Pract 7:1–6

    Article  Google Scholar 

  4. Gebreyohannes EA, Bhagavathula AS, Abebe TB, Tefera YG, Abegaz TM (2019) Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital. Clin Hypertens 25:1–9

    Article  Google Scholar 

  5. Moradi B, Abbaszadeh S, Shahsavari S, Alizadeh M, Beyranvand F (2018) The most useful medicinal herbs to treat diabetes. Biomed Res Ther 5:2538–2551

    Article  Google Scholar 

  6. Landazuri P, Chamorro NL, Cortes BR (2017) Medicinal plants used in the management hypertension. J Anal Pharm Res 5:1–3

    Article  Google Scholar 

  7. Devaki K, Beulah U, Akila G, Sunitha M, Gopalakrishnan VK (2011) Hypoglycemic activity of Passiflora edulis sims leaf extract in Wistar albino rats. Int Res J Pharm 2:170–172

    Google Scholar 

  8. Ichimura T, Yamanaka A, Ichiba T, Toyokawa T, Kamada Y, Tamamura T, Maruyama S (2006) Antihypertensive effect of an extract of Passiflora edulis Rind in spontaneously hypertensive rats. Biosci Biotechnol Biochem 70:718–721

    Article  CAS  Google Scholar 

  9. Salgado JM, Bombarde TAD, Mansi DN, Piedade SMS, Meletti LMM (2010) Effects of different concentrations of passion fruit peel (Passiflora edulis) on the glicemic control in diabetic mice. J Food Sci Technol 30:784–789

    Article  Google Scholar 

  10. Pinheiro ER, Silva IMDA, Gonzaga LV, Amante ER, Teófilo RF, Ferreira MMC, Amboni RDMC (2008) Optimization of extraction of high-ester pectin from passion fruit eel (Passiflora edulis Flavicarpa) with citric acid by using response surface methodology. Bioresour Technol 99:5561–5566

    Article  CAS  Google Scholar 

  11. Cazarin CBB, Rodriguez-Nogales A, Francesca A, Utrilla MP, Rodríguez-Cabezas ME, Garrido-Mesa J, Guerra-Hernández E, Braga PAC, Reyes FGR, Maróstica MR, Gálvez J (2016) Intestinal anti-inflammatory effects of Passiflora edulis peel in the dextran sodium sulphate model of mouse colitis. J Funct Foods 26:565–576

    Article  CAS  Google Scholar 

  12. Vinayagam R, Xu B (2015) Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Nutr Metab 12:1–20

    Article  Google Scholar 

  13. Maalik D, Shaito AA, Pintus G, El-Yazbi A, Eid AH (2019) Flavonoids in hypertension: a brief review of the underlying mechanisms. Curr Opin Pharmacol 45:57–65

    Article  Google Scholar 

  14. Sorensen CM, Giese I, Braunstein TH, Holstein-Rathlou NH, Salomonsson M (2011) closure of multiple types of K+ channels is necessary to induce changes in renal vascular resistance in vivo in rats. Pflugers Arch 5:655–667

  15. Cazarin CBB, Silva JK, Colomeu TC, Zollner RL, Marostica MR (2014) Antioxidant capacity and chemical composition of passion fruit peel (Passiflora edulis)/capacidade antioxidante e composicao quimica da casca de maracuja (Passiflora edulis). Cienc Rural 44:1699–1704

    Article  Google Scholar 

  16. He X, Luan F, Yang Y, Wang Z, Zhao Z, Fang J, Wang M, Zuo M, Li Y (2020) Passiflora edulis: an insight into current researches on phytochemistry and pharmacology. Front Pharmacol 11:1–16

    Article  Google Scholar 

  17. Fu XC, Wang MW, Li SP, Zhang Y, Wang HL (2005) Vasodilatation produced by orientin and its mechanism study. Biol Pharm Bull 28:37–41

    Article  CAS  Google Scholar 

  18. Woerdenbag HJ, Nguyen TM, Vu DV, Tran H, Nguyen DT, Tran TV (2012) Vietnamese traditional medicine from a pharmacista [euro] [TM]s perspective. Expert Rev Clin Pharmacol 5:459–477

    Article  CAS  Google Scholar 

  19. Zucolotto SM, Goulart S, Montanher AB, Reginatto FH, Schenkel EP, Fröde TS (2009) Bioassay-guided isolation of anti-inflammatory C-glucosylflavones from Passiflora edulis. Planta Med 75:1221–1226

    Article  CAS  Google Scholar 

  20. Malik A, Jamil U, Butt TT, Waquar S, Gan SH, Shafique H, Jafar TH (2019) In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model. Drug Des Devel Ther 13:1501–1513

    Article  CAS  Google Scholar 

  21. Abboud KY, Luz BB, Dallazen JL, Werner MFP, Cazarin CBB, Maróstica JMR, Iacomini M, Cordeiro LMC (2019) Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats. J Funct Foods 54:552–558

    Article  CAS  Google Scholar 

  22. Silva DC, Freitas A, Pessoa C, Paula R, Mesquita J, Leal L, Brito G, Goncalves D, Viana G (2011) Pectin from Passiflora edulis shows antiinflammatory action as well as hypoglycemic and hypotriglyceridemic properties in diabetic rats. J Med Food 14:1118–1126

    Article  CAS  Google Scholar 

  23. Sibiya N, Ngubane P, Mabandla M (2017) The ameliorative effect of pectin insulin patch on renal injury in streptozotocin-induced diabetic rats. Kidney Blood Press Res 42:530–540

    Article  CAS  Google Scholar 

  24. Assis KS, Araújo IGA, Azevedo FLAA, Maciel PMP, Machado-Calzerra NT, Silva TAF, Assis VL, Vasconcelos AP, Santos CAG, Meireles BRLA, Cordeiro AMTM, Araújo DAM, Ribeiro TP, Medeiros IA (2018) Potassium channel activation is involved in the cardiovascular effects induced by freeze dried Syzygium jambolanum (Lam.) DC fruit juice. Biomed Res Int 2018:1–12

    Article  Google Scholar 

  25. Soumya RS, Raj KB, Abraham A (2021) Passiflora edulis (var. Flavicarpa) juice supplementation mitigates isoproterenol-induced myocardial infarction in rats. Plant Foods Hum Nutr 76:189–195

    Article  CAS  Google Scholar 

  26. Braga A, Medeiros TP, Araujo BV (2010) Investigation of antihyperglycemic activity of Passiflora edulis sims, Passifloraceae, in alloxan-induced diabetic rats. Braz J Pharmacog 20:186–191

    Article  Google Scholar 

  27. Verma AK, Pratap R (2010) The biological potential of flavones. Nat Prod Rep 27:1571–1593

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors are grateful to the CAPES for the PhD scholarship (88882.375434/2019-01)

Funding

The research was funded by the Brazilian research funding agencies: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). SZ is a research productivity fellow of the CNPq (Grant number 313727/2020–1).

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Authors and Affiliations

  1. PNBIO, Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Norte (UFRN), Natal, RN, Brazil

    Bárbara Cabral, Jovelina Samara Ferreira Alves & Silvana Maria Zucolotto

  2. Department of Clinical and Toxicological Analyses, Federal University of Rio Grande Do Norte, Avenue Gen. Gustavo Cordeiro de Faria, Natal, RN, Brazil

    Raul Hernandes Bortolin & Adriana Augusto de Rezende

  3. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Science, University of Sao Paulo, Sao Paulo, SP, Brazil

    Raul Hernandes Bortolin

  4. Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil

    Tays Amanda Felisberto Gonçalves, Priscilla Maria Pereira Maciel, Alinne Villar de Arruda & Isac Almeida de Medeiros

  5. Department of Morphology, Federal University of Rio Grande Do Norte, Natal, Brazil

    Thais Gomes de Carvalho

  6. Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil

    Kahlile Youssef Abboud & Lucimara M. C. Cordeiro

Authors
  1. Bárbara Cabral
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  2. Raul Hernandes Bortolin
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  3. Tays Amanda Felisberto Gonçalves
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  4. Priscilla Maria Pereira Maciel
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  5. Alinne Villar de Arruda
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  6. Thais Gomes de Carvalho
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  7. Kahlile Youssef Abboud
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  8. Jovelina Samara Ferreira Alves
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  9. Lucimara M. C. Cordeiro
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  10. Isac Almeida de Medeiros
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  11. Adriana Augusto de Rezende
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  12. Silvana Maria Zucolotto
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Contributions

All authors contributed to the performance of the review. The literature search and writing were done by Bárbara Cabral; supervision and literature advice were performed by Raul Hernandes Bortolin; Tays Amanda Felisberto Gonçalves; Alinne Villar de Arruda; Thais Gomes de Carvalho; Kahlile Youssef Abboud and Jovelina Samara Ferreira Alves; the critical and final revision was done by Silvana Maria Zucolotto; Adriana Augusto de Rezende; Isac Almeida de Medeiros and Lucimara M.C. Cordeiro.

Corresponding author

Correspondence to Silvana Maria Zucolotto.

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Cabral, B., Bortolin, R.H., Gonçalves, T.A.F. et al. Hypoglycemic and Vasorelaxant Effect of Passiflora edulis Fruit Peel By-Product. Plant Foods Hum Nutr 76, 466–471 (2021). https://doi.org/10.1007/s11130-021-00921-8

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