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Honey as the Potential Natural Source of Cholinesterase Inhibitors in Alzheimer’s Disease

  • Ewa Baranowska-Wójcik
  • Dominik SzwajgierEmail author
  • Anna Winiarska-Mieczan
Short Communication

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized, among others by abnormal levels of acetyl- and butyrylcholinesterase in the brain. In this study, 47 types of Polish honeys were examined (using colorimetric method) as a source of acetyl- and butyrylcholinesterase inhibitors. The highest potential for AChE inhibition was observed in the case of buckwheat honey (39.51% inhibition), while multi-floral honey showed the highest capacity for BChE inhibition (39.76%). Our study revealed that honeys can be a rich source of cholinesterase inhibitors and therefore may play a role in AD treatment.

Keywords

Acetylcholine AChE BChE Honey Alzheimer’s disease 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

This article does not contain any studies with human or animal subjects.

Supplementary material

11130_2019_791_MOESM1_ESM.doc (101 kb)
Table S1 (DOC 101 kb)
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Table S2 (DOC 84 kb)
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Figure S1 (DOC 197 kb)
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Figure S2 (DOC 183 kb)
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Figure S3 (DOC 232 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Ewa Baranowska-Wójcik
    • 1
  • Dominik Szwajgier
    • 1
    Email author
  • Anna Winiarska-Mieczan
    • 2
  1. 1.Department of Biotechnology, Microbiology and Human NutritionUniversity of Life Sciences in LublinLublinPoland
  2. 2.Department of Bromatology and Food PhysiologyUniversity of Life Sciences in LublinLublinPoland

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