Pomegranate (Punica granatum) is known to contain polyphenols with many potential health benefits, including anti-tumoral, anti-inflammatory, and anti-microbial properties. It has been used in popular medicine for cancer treatment, which still represents the major cause of cancer-related deaths in men worldwide. Importantly, pomegranate peels are valuable by-products of the food industry that are rich in polyphenols. Here we report a comparison between juice and peel aqueous extracts in prostate cancer DU-145 and PC-3 cell lines. Both extracts were able to inhibit the proliferation, migration and colony formation of those cells, although peel extracts presented more robust effects compared to juice. Besides, the growth-related mTOR/S6K signaling pathway presented strong inhibition after pomegranate extracts treatment. This study presents evidence that both juice and isolated peel extracts from promegate fruit have important anti-cancer effects against prostate cancer cells, modulating the mTOR/S6K signaling pathway.
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Mammalian Target Of Rapamycin
Fetal bovine serum
High-Performance Liquid Chromatography
Transgenic adenocarcinoma of the mouse prostate
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This research has been funded by The São Paulo Research Foundation (grant numbers: FMS, 2012/13558-7 and 2018/14818-9; AECA, 2015/07299-7; RMNB, 2016/06457-0; MAR, 2013/04304-4; fellowship numbers: ICBP, 2015/003111; LBF, 2013/13002-1) and from CNPq (FMS, 447553/2014-3; MAR, 303568/2016-0).
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Chaves, F.M., Pavan, I.C.B., da Silva, L.G.S. et al. Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway. Plant Foods Hum Nutr (2019). https://doi.org/10.1007/s11130-019-00776-0
- Peel extracts
- Ellagic acid
- Prostate cancer
- Cell signaling