Nutraceutical Properties of Herbal Infusions from Six Native Plants of Argentine Patagonia
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Six native plants of South America traditionally consumed in the Patagonian region (southern Argentina and Chile), namely: Adesmia boronioides Hook. f., Apium australe Thouars, Buddleja globosa Hope, Drimys andina (Reiche) R. Rodr. & Quezada, Dysphania multifida L. and Solidago chilensis Meyen were investigated to determine the nutraceutical properties of infusions of their aerial parts. The infusions were characterized in terms of their antioxidant activity, phenolic and flavonoid content, profile of phenolic compounds, general toxicity and cytotoxicity on two different human cell lines: T84 (derived from colon cancer) and HTR8/SVneo (not derived from cancer). Twenty-nine compounds, mainly phenolic acids and flavonoids, were identified. This is the first analysis of phenolic compounds in infusions from native plants of Patagonia. D. andina, B. globosa and S. chilensis showed high levels of antioxidants, even higher than those of Green Tea. The content of phenolic compounds correlated significantly with the antioxidant activity of the samples analyzed. The toxicity test indicated that the use of A. australe, B. globosa and D. multifida seems safe, but a moderate consumption is suggested for A. boronioides, D. andina and S. chilensis until more exhaustive and long-term results are available. Moreover, A. boronioides and S. chilensis showed anticancer potential due to their antiproliferative activity on human cancer cell lines.
KeywordsAntioxidant activity Antiproliferative activity Infusions Native plants Argentine Patagonia Phenolic compounds
American Type Culture Collection
β-carotene-linoleic acid method
Efficient concentration 50
Gallic acid equivalent
Cancer cell line from placental tissue
Lethal concentration 50
Liquid chromatography with diode array detection with tandem mass spectrometry
Cancer cell line from colon
Total phenolic compound content
Total flavonoid content
Vitamin C equivalent antioxidant capacity
We would like to thank Direction of Flora and Fauna Silvestre, Chubut, Argentina, for allowing the sustainable collection of plant material in wild populations. We thank Dr. Nora B. Muruaga and staff of Miguel Lillo Institute for the identification of the botanical material and its deposit in the herbarium. We also thank the anonymous reviewers for their constructive suggestions, which have greatly improved the manuscript. This work has been supported in part by CONICET, Argentina.
Compliance with Ethical Standards
Human or Animal Studies
This article does not contain any studies with human or animal subjects.
Conflict of Interest
The authors declare that there is no conflict of interest regarding the publication of this paper.
- 3.Barboza G, Cantero J, Ñúnez C, Pacciaroni A, Espinar LA (2009) Medicinal plants: a general review and a phytochemical and ethnopharmacological screening of the native Argentine Flora. Kurtziana 34:7–365Google Scholar
- 9.Gastaldi B, Catalan CAN, Silva-Sofrás FM, González SB (2018) Solidago chilensis Meyen (Asteraceae), a medicinal plant from South America. A comprehensive review: ethnomedicinal uses, phytochemistry and bioactivity. B Latinoam Caribe Pl 17(1):17–29Google Scholar
- 20.Wagner H, Baldt S (2001) Plant drug analysis. A thin layer chromatography atlas. Springer, München, p 384Google Scholar
- 26.Neveu V, Perez-Jiménez J, Vos F, Crespy V, du Chaffaut L, Mennen L, Knox C, Eisner R, Cruz J, Wishart D, Scalbert A (2010) Phenol-explorer: an online comprehensive database on polyphenol contents in foods. Database. https://doi.org/10.1093/database/bap024 Accessed 06 February 2018
- 34.Yanez J, Vicente V, Alcatraz M, Castillo J, Benavente-García O, Canteras M, Teruel L (2004) Cytotoxicity and antiproliferative activities of several phenolic compounds against three melanocytes cell lines: relationship between structure and activity. Nutr Cancer 49(2):191–199CrossRefPubMedGoogle Scholar