Acidogenic diets, commonly measured by the potential renal acid load (PRAL), have been linked with metabolic diseases including insulin resistance, hepatic dysfunction, and cardiometabolic risk. Vegan diets are linked to low dietary acid loads, but the degree of adherence to a vegan diet to demonstrate this benefit is unknown. This study compared the change in PRAL and urine pH of omnivores who followed a vegan diet for either 2, 3, or 7 days over one week. Healthy adults were recruited from a campus population and randomly assigned to one of the three groups: VEG7 (vegan diet followed for seven consecutive days); VEG3 (vegan diet followed for three evenly spaced days over one week); or VEG2 (vegan diet followed for two evenly spaced days over one week). Gender, age, and body mass index did not differ between groups (overall: 21.8 ± 2.4 y and 24.4 ± 5.6 kg/m2). Following the one week intervention, outcome measures did not vary between the VEG2 and VEG3 groups, and these groups were collapsed for the final analyses. The 24-h urine pH was raised after seven consistent days of vegan diet adherence and was unchanged after 2–3 days of vegan diet adherence over the course of a week (+0.52 ± 0.69 and −0.02 ± 0.56 respectively, p = 0.048). However, dietary PRAL scores fell significantly in both dietary groups during the 7-day trial. Since low dietary PRAL scores have been related to improve metabolic parameters, adoption of a vegan diets for several days per week should be explored as a diet strategy to lower disease risk.
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Orlich MJ, Fraser GE (2014) Vegetarian diets in the Adventist health study 2: a review of initial published findings. Am J Clin Nutr 100(Suppl 1):353S–358S
Li D (2014) Effect of the vegetarian diet on non-communicable diseases. J Sci Food Agric 94:169–173
Rao V, Al-Weshahy A (2008) Plant-based diets and control of lipids and coronary heart disease risk. Curr Atheroscler Rep 10:478–485
Deriemaeker P, Aerenhouts D, Hebbelinck M, Clarys P (2010) Nutrient based estimation of acid-base balance in vegetarians and non-vegetarians. Plant Foods Hum Nutr 65:77–82
Welch AA, Mulligan A, Bingham SA, Khaw KT (2008) Urine pH is an indicator of dietary acid-base load, fruit and vegetables and meat intakes: results from the European prospective investigation into cancer and nutrition (EPIC)-Norfolk population study. Br J Nutr 99:1335–1343
Scialla JJ, Anderson CA (2013) Dietary acid load: a novel nutritional target in chronic kidney disease? Adv Chronic Kidney Dis 20:141–149
Remer T, Manz F (1995) Potential renal acid load of foods and its influence on urine pH. J Am Diet Assoc 95:791–797
Akter S, Eguchi M, Kuwahara K, Kochi T, Ito R, Kurotani K et al (2016) High dietary acid load is associated with insulin resistance: the Furukawa nutrition and health study. Clin Nutr 35:453–459
Moghadam SK, Bahadoran Z, Mirmiran P, Tohidi M, Azizi F (2016) Association between dietary acid load and insulin resistance: Tehran lipid and glucose study. Prev Nutr Food Sci 21:104–109
Krupp D, Johner SA, Kalhoff H, Buyken AE, Remer T (2012) Long-term dietary potential renal acid load during adolescence is prospectively associated with indices of nonalcoholic fatty liver disease in young women. J Nutr 142:313–319
Murakami K, Sasaki S, Takahashi Y, Uenishi K, Japan Dietetic Students' Study for Nutrition and Biomarkers Group (2008) Association between dietary acid-base load and cardiometabolic risk factors in young Japanese women. Br J Nutr 100:642–651
Han E, Kim G, Hong N, Lee YH, Kim DW, Shin HJ et al (2016) Association between dietary acid load and the risk of cardiovascular disease: nationwide surveys (KNHANES 2008-2011). Cardiovasc Diabetol 15:122
Knurick JR, Johnston CS, Wherry SJ, Aguayo I (2015) Comparison of correlates of bone mineral density in individuals adhering to lacto-ovo, vegan, or omnivore diets: a cross-sectional investigation. Nutrients 7:3416–3426
Gallup (2012) U.S., 5% consider themselves vegetarian . Available online at: www.gallup.com/poll/156215/consider-themselves-vegetarians.aspx
Remer T, Dimitriou T, Manz F (2003) Dietary potential renal acid load and renal net acid excretion in healthy, free-living children and adolescents. Am J Clin Nutr 77:1255–1260
Clarys P, Deliens T, Huybrechts I, Deriemaeker P, Vanaelst B, De Keyzer W et al (2014) Comparison of nutritional quality of the vegan, vegetarian, semi-vegetarian, pesco-vegetarian and omnivorous diet. Nutrients 6:1318–1332
Schmidt JA, Rinaldi S, Scalbert A, Ferrari P, Achaintre D, Gunter MJ et al (2016) Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort. Eur J Clin Nutr 70:306–312
Fagherazzi G, Vilier A, Bonnet F, Lajous M, Balkau B, Boutron-Rualt MC et al (2014) Dietary acid load and risk of type 2 diabetes: the E3N-EPIC cohort study. Diabetologia 57:313–320
Mandel EI, Curhan GC, Hu FB, Taylor EN (2012) Plasma bicarbonate and risk of type 2 diabetes mellitus. CMAJ 184:E719–E725
Whittaker J, Cuthbert C, Hammond VA, Alberti KG (1982) The effects of metabolic acidosis in vivo on insulin binding to isolated rat adipocytes. Metabolism 31:553–557
Xu H, Åkesson A, Orsini N, Håkansson N, Wolk A, Carrero JJ (2016) Modest U-shaped association between dietary acid load and risk of all-cause and cardiovascular mortality in adults. J Nutr 146:1580–1585
Kurtz I, Maher T, Hulter HN, Schambelan M, Sebastian A (1983) Effect of diet on plasma acid-base composition in normal humans. Kidney Int 24:670–680
Cao JJ, Johnson LK, Hunt JR (2011) A diet high in meat protein and potential renal acid load increases fractional calcium absorption and urinary calcium excretion without affecting markers of bone resorption or formation in postmenopausal women. J Nutr 141:391–397
Bulló M, Amigó-Correig P, Márquez-Sandoval F, Babio N, Martínez-González MA, Estruch R et al (2009) Mediterranean diet and high dietary acid load associated with mixed nuts: effect on bone metabolism in elderly subjects. J Am Geriatr Soc 57:1789–1798
We thank Noel Ugarte for excellent technical assistance in diet entry.
This research was funded by the Graduate and Professional Students Association and the Office of the Vice Provost for Research.
Conflict of Interest
The authors declare no conflict of interest.
Human and Animal Rights and Informed Consent
This research involved human subjects. The research was approved by the Institutional Review Board at Arizona State University and written consent was obtained from all participants.
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Cosgrove, K., Johnston, C.S. Examining the Impact of Adherence to a Vegan Diet on Acid-Base Balance in Healthy Adults. Plant Foods Hum Nutr 72, 308–313 (2017). https://doi.org/10.1007/s11130-017-0620-7
- Potential renal acid load
- Urine pH
- Vegan diets