Plant Foods for Human Nutrition

, Volume 70, Issue 4, pp 441–453 | Cite as

Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits

  • Maryem Ben Salem
  • Hanen AffesEmail author
  • Kamilia Ksouda
  • Raouia Dhouibi
  • Zouheir Sahnoun
  • Serria Hammami
  • Khaled Mounir Zeghal
Review Article


Artichoke (Cynara scolymus) leaf extract was one of the few herbal remedies which the clinical and experimental trials have complemented each other. Both experimental and clinical effects have been verified through extensive biomedical herbal remedy research. Specifically, antioxidant, choleretic, hepatoprotective, bile-enhancing and lipid-lowering effects have been demonstrated, which corresponded with its historical use. Ongoing research seems to indicate that artichoke indeed have medicinal qualities. Most significant appears to be its beneficial effect on the liver. In animal studies, liquid extracts of the roots and leaves of artichoke have demonstrated an ability to protect the liver, with possibly even to help liver cells regenerate. Although research is not yet conclusive, scientists were optimistic that its long-standing use in humans for digestive and bowel problems was indeed justified. It may also play a role in lowering cholesterol and thus help to prevent heart disease. Boiled wild artichoke reduced postprandial glycemic and insulinemic responses in normal subjects but has no effect on metabolic syndrome patients. This article intended to review the wide ranging pharmacological effects of artichoke leaf extract.


Artichoke leaves extract Cardiovascular disorders Antioxidant Hepato-protective 



Artichaut leaf extract


Cynara scolymus


Low density lipoprotein-cholesterol


Diabetes mellitus


Non alcoholic steatohepatitis


Conflict of Interest

The authors declare that they  have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Maryem Ben Salem
    • 1
  • Hanen Affes
    • 1
    • 2
    Email author
  • Kamilia Ksouda
    • 1
  • Raouia Dhouibi
    • 1
  • Zouheir Sahnoun
    • 1
  • Serria Hammami
    • 1
  • Khaled Mounir Zeghal
    • 1
  1. 1.Laboratoire de pharmacologieFaculté de Medecine SfaxSfaxTunisia
  2. 2.Laboratory of PharmacologyFaculty of Medicine of SfaxSfaxTunisie

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