Plant Foods for Human Nutrition

, Volume 68, Issue 2, pp 145–148 | Cite as

A Study of Glycemic Response to Corinthian Raisins in Healthy Subjects and in Type 2 Diabetes Mellitus Patients

  • Panagiotis T. Kanellos
  • Andriana C. Kaliora
  • Christos Liaskos
  • Nikolaos K. Tentolouris
  • Despina Perrea
  • Vaios T. Karathanos
Original Paper


This study was designed to evaluate the metabolic response to Corinthian raisins in healthy and in patients with type 2 diabetes mellitus. Healthy subjects (n = 15) and diabetic patients (n = 15) received 74 g raisins or 50 g glucose as reference food. Blood samples were collected at time 0 (before the consumption) and 30, 60, 90, 120, 150 and 180 min after raisin or glucose consumption. There was no significant difference in baseline glucose and insulin between raisins and reference in both groups. The difference at glucose peaks between raisins and reference was significant in healthy and in diabetics. Glycemic and insulinemic responses were decreased after raisin consumption compared to reference. An estimate of the glycemic index would be 66.3 ± 3.4.


Corinthian raisins Blood glucose Glycemic response Insulinemic response 



Area under the curve


Body mass index


Corinthian raisins


Glycemic index


Glycemic load


Glycated hemoglobin


Insulin index


Type 2 diabetes mellitus



The study was funded by the Corinthian Raisins Cooperative SKOS A.S.E. within the framework of NSRF 2007-2013 Programme for Development (EU Regional Development Fund), Greek Ministry of Education and Religious Affairs, Cuture & Sports. Corinthian Raisins were kindly donated by the Agricultural Cooperatives Union - Aeghion, Greece (P.E.S. Union).

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Barclay AW, Petocz P, McMillan-Price J, Flood VM, Prvan T, Mitchell P, Brand-Miller JC (2008) Glycemic index, glycemic load, and chronic disease risk-a meta-analysis of observational studies. Am J Clin Nutr 87:627–637Google Scholar
  2. 2.
    Menezes EW, Dan MC, Cardenette GH, Goñi I, Bello-Pérez LA, Lajolo FM (2010) In vitro colonic fermentation and glycemic response of different kinds of unripe banana flour. Plant Foods Hum Nutr 65:379–385CrossRefGoogle Scholar
  3. 3.
    Rendell M, Vanderhoof J, Venn M, Shehan MA, Arndt E, Rao CS, Gill G, Newman RK, Newman CW (2005) Effect of a barley breakfast cereal on blood glucose and insulin response in normal and diabetic patients. Plant Foods Hum Nutr 60:63–67CrossRefGoogle Scholar
  4. 4.
    Chiou A, Karathanos VT, Mylona A, Salta FN, Preventi F, Andrikopoulos NK (2007) Currants (Vitis vinifera L.) content of simple phenolics and antioxidant activity. Food Chem 102:516–522Google Scholar
  5. 5.
    Andrade-Cetto A, Wiedenfeld H (2001) Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J Ethnopharmacol 78:145–149Google Scholar
  6. 6.
    American Diabetes Association (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33:S62–S69Google Scholar
  7. 7.
    Pagana KD, Pagana TJ (2010) Mosby’s manual of diagnostic and laboratory tests. In: Pagana KD, Pagana TJ (eds) Blood Studies, 4th edn. Elsevier, St Louis, pp 270–275Google Scholar
  8. 8.
    Wolever TMS, Jenkins DJA, Jenkins AL, Josse RG (1991) The glycemic index: methodology and clinical implications. Am J Clin Nutr 54:846–854Google Scholar
  9. 9.
    Webster SGP, Leeming JT (1975) Assessment of small bowel function in the elderly using a modified xylose tolerance test. Gut 16:109–113CrossRefGoogle Scholar
  10. 10.
    Levitan EB, Cook NR, Stampfer MJ, Ridker PM, Rexrode KM, Buring JE, Manson JE, Liu S (2008) Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein. Metabolism 57:437–443CrossRefGoogle Scholar
  11. 11.
    Jiang R, Jacobs DR, Mayer-Davis E, Szklo M, Herrington D, Jenny NS, Kronmal R, Barr RG (2006) Nut and seed consumption and inflammatory markers in the multi-ethnic study of atherosclerosis. Am J Epidemiol 163:222–231CrossRefGoogle Scholar
  12. 12.
    Jenkins DJ, Srichaikul K, Kendall CW, Sievenpiper JL, Abdulnour S, Mirrahimi A, Meneses C, Nishi S, He X, Lee S et al (2011) The relation of low glycaemic index fruit consumption to glycaemic control and risk factors for coronary heart disease in type 2 diabetes. Diabetologia 54:271–279CrossRefGoogle Scholar
  13. 13.
    Matsui T, Ebuchi S, Kobayashi M, Fukui K, Sugita K, Terahara N, Matsumoto K (2002) Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the alpha-glucosidase inhibitory action. J Agric Food Chem 50:7244–7248Google Scholar
  14. 14.
    Liu IM, Tzeng TF, Liou SS, Lan TW (2007) Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats. Life Sci 81:1479–1488CrossRefGoogle Scholar
  15. 15.
    Wursch P, Pi-Sunyer FX (2002) The role of viscous soluble fiber in the metabolic control of diabetes: a review with special emphasis on cereals rich in beta-glucan. Diabetes Care 20:1774–1780CrossRefGoogle Scholar
  16. 16.
    Wolever TMS (2000) Dietary carbohydrates and insulin action in humans. Br J Nutr 83:S97–S102CrossRefGoogle Scholar
  17. 17.
    Jenkins DJA, Axelsen M, Kendall CWC, Augustin LSA, Vuksan V, Smith U (2000) Dietary fibre, lente carbohydrates and the insulin-resistant disease. Br J Nutr 83:S157–S163CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Panagiotis T. Kanellos
    • 1
  • Andriana C. Kaliora
    • 1
  • Christos Liaskos
    • 2
  • Nikolaos K. Tentolouris
    • 2
  • Despina Perrea
    • 3
  • Vaios T. Karathanos
    • 1
  1. 1.Department of Science of Dietetics–NutritionHarokopio UniversityAthensGreece
  2. 2.1st Department of Propaedeutic and Internal Medicine, Laiko General HospitalNational and Kapodistrian University, Medical SchoolAthensGreece
  3. 3.Laboratory of Experimental Surgery and Surgical Research N.S. ChristeasNational and Kapodistrian University, Medical SchoolAthensGreece

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