A Study of Glycemic Response to Corinthian Raisins in Healthy Subjects and in Type 2 Diabetes Mellitus Patients
This study was designed to evaluate the metabolic response to Corinthian raisins in healthy and in patients with type 2 diabetes mellitus. Healthy subjects (n = 15) and diabetic patients (n = 15) received 74 g raisins or 50 g glucose as reference food. Blood samples were collected at time 0 (before the consumption) and 30, 60, 90, 120, 150 and 180 min after raisin or glucose consumption. There was no significant difference in baseline glucose and insulin between raisins and reference in both groups. The difference at glucose peaks between raisins and reference was significant in healthy and in diabetics. Glycemic and insulinemic responses were decreased after raisin consumption compared to reference. An estimate of the glycemic index would be 66.3 ± 3.4.
KeywordsCorinthian raisins Blood glucose Glycemic response Insulinemic response
Area under the curve
Body mass index
Type 2 diabetes mellitus
The study was funded by the Corinthian Raisins Cooperative SKOS A.S.E. within the framework of NSRF 2007-2013 Programme for Development (EU Regional Development Fund), Greek Ministry of Education and Religious Affairs, Cuture & Sports. Corinthian Raisins were kindly donated by the Agricultural Cooperatives Union - Aeghion, Greece (P.E.S. Union).
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Barclay AW, Petocz P, McMillan-Price J, Flood VM, Prvan T, Mitchell P, Brand-Miller JC (2008) Glycemic index, glycemic load, and chronic disease risk-a meta-analysis of observational studies. Am J Clin Nutr 87:627–637Google Scholar
- 4.Chiou A, Karathanos VT, Mylona A, Salta FN, Preventi F, Andrikopoulos NK (2007) Currants (Vitis vinifera L.) content of simple phenolics and antioxidant activity. Food Chem 102:516–522Google Scholar
- 5.Andrade-Cetto A, Wiedenfeld H (2001) Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J Ethnopharmacol 78:145–149Google Scholar
- 6.American Diabetes Association (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33:S62–S69Google Scholar
- 7.Pagana KD, Pagana TJ (2010) Mosby’s manual of diagnostic and laboratory tests. In: Pagana KD, Pagana TJ (eds) Blood Studies, 4th edn. Elsevier, St Louis, pp 270–275Google Scholar
- 8.Wolever TMS, Jenkins DJA, Jenkins AL, Josse RG (1991) The glycemic index: methodology and clinical implications. Am J Clin Nutr 54:846–854Google Scholar
- 12.Jenkins DJ, Srichaikul K, Kendall CW, Sievenpiper JL, Abdulnour S, Mirrahimi A, Meneses C, Nishi S, He X, Lee S et al (2011) The relation of low glycaemic index fruit consumption to glycaemic control and risk factors for coronary heart disease in type 2 diabetes. Diabetologia 54:271–279CrossRefGoogle Scholar
- 13.Matsui T, Ebuchi S, Kobayashi M, Fukui K, Sugita K, Terahara N, Matsumoto K (2002) Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the alpha-glucosidase inhibitory action. J Agric Food Chem 50:7244–7248Google Scholar