Oat Prevents Obesity and Abdominal Fat Distribution, and Improves Liver Function in Humans
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Obesity is associated with a great diversity of diseases including non-alcoholic fatty liver disease. Our recent report suggested that oat, rich in beta-glucan, had a metabolic-regulating and liver-protecting effect in an animal model. In this study, we performed a clinical trial to further confirm the effect of oat. Subjects with BMI ≧27 and aged 18–65, were randomly divided into a control (n = 18) and an oat-treated (n = 16) group, taking a placebo or beta glucan-containing oat cereal, respectively, for 12 weeks. Our data showed that consumption of oat reduced body weight, BMI, body fat and the waist-to-hip ratio. Profiles of hepatic function, including AST, but especially ALT, were useful resources to help in the evaluation of the liver, since both showed decrements in patients with oat consumption. Nevertheless, anatomic changes were still not observed by ultrasonic image analysis. Ingestion of oat was well tolerated and there was no adverse effect during the trial. In conclusion, consumption of oat reduced obesity, abdominal fat, and improved lipid profiles and liver functions. Taken as a daily supplement, oat could act as an adjuvant therapy for metabolic disorders.
KeywordsOat Obesity Abdominal body fat Fatty liver
Body mass index
Blood urea nitrogen
Free fatty acids
Fatty liver scores
High-density lipoprotein cholesterol
Low-density lipoprotein cholesterol
We thank STANDARD Foods Co., Taiwan for providing all experimental diets.
- 4.Gasbarrini G, Vero V, Miele L, Forgione A, Hernandez AP, Greco AV, Gasbarrini A, Grieco A (2005) Nonalcoholic fatty liver disease: Defining a common problem. Eur Rev Med Pharmacol Sci 9(5):253–259Google Scholar
- 8.Maki KC, Beiseigel JM, Jonnalagadda SS, Gugger CK, Reeves MS, Farmer MV, Kaden VN, Rains TM (2010) Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods. J Am Diet Assoc 110(2):205–214CrossRefGoogle Scholar
- 10.Reyna-Villasmil N, Bermudez-Pirela V, Mengual-Moreno E, Arias N, Cano-Ponce C, Leal-Gonzalez E, Souki A, Inglett GE, Israili ZH, Hernandez-Hernandez R, Valasco M, Arraiz N (2007) Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia. Am J Ther 14(2):203–212CrossRefGoogle Scholar
- 12.Peng CH, Chang HC, Yang MY, Huang CN, Wang SJ, Wang CJ (2012) Oat attenuate non-alcoholic fatty liver and obesity via inhibiting lipogenesis in high fat-fed rat. J Funct Foods, in press http://dx.doi.org/10.1016/j.jff.2012.08.003.
- 15.Charbonneau-Roberts G, Saudny-Unterberger H, Kuhnlein HV, Egeland GM (2005) Body mass index may overestimate the prevalence of overweight and obesity among the Inuit. Int J Circumpolar Health 64(2):163–169Google Scholar
- 16.Sanyal D, Mukhopadhyay P, Pandit K, Mukhopadhyay S, Chowdhury S (2009) Central obesity but not generalised obesity (body mass index) predicts high prevalence of fatty liver (NRFLD), in recently detected untreated, IGT and type 2 diabetes Indian subjects. J Indian Med Assoc 107(11):755–758Google Scholar
- 18.Esteghamati A, Noshad S, Khalilzadeh O, Khalili M, Zandieh A, Nakhjavani M (2011) Insulin resistance is independently associated with liver aminotransferases in diabetic patients without ultrasound signs of nonalcoholic fatty liver disease. Metab Syndr Relat Disord 9(2):111–117CrossRefGoogle Scholar
- 20.Wolever TM, Tosh SM, Gibbs AL, Brand-Miller J, Duncan AM, Hart V, Lamarche B, Thomson BA, Duss R, Wood PJ (2010) Physicochemical properties of oat beta-glucan influence its ability to reduce serum LDL cholesterol in humans: A randomized clinical trial. Am J Clin Nutr 92(4):723–732CrossRefGoogle Scholar
- 21.Wood PJ, Beer MU, Butler G (2000) Evaluation of role of concentration and molecular weight of oat beta-glucan in determining effect of viscosity on plasma glucose and insulin following an oral glucose load. Br J Nutr 84(1):19–23Google Scholar