Plant Foods for Human Nutrition

, Volume 68, Issue 1, pp 18–23 | Cite as

Oat Prevents Obesity and Abdominal Fat Distribution, and Improves Liver Function in Humans

Original Paper

Abstract

Obesity is associated with a great diversity of diseases including non-alcoholic fatty liver disease. Our recent report suggested that oat, rich in beta-glucan, had a metabolic-regulating and liver-protecting effect in an animal model. In this study, we performed a clinical trial to further confirm the effect of oat. Subjects with BMI ≧27 and aged 18–65, were randomly divided into a control (n = 18) and an oat-treated (n = 16) group, taking a placebo or beta glucan-containing oat cereal, respectively, for 12 weeks. Our data showed that consumption of oat reduced body weight, BMI, body fat and the waist-to-hip ratio. Profiles of hepatic function, including AST, but especially ALT, were useful resources to help in the evaluation of the liver, since both showed decrements in patients with oat consumption. Nevertheless, anatomic changes were still not observed by ultrasonic image analysis. Ingestion of oat was well tolerated and there was no adverse effect during the trial. In conclusion, consumption of oat reduced obesity, abdominal fat, and improved lipid profiles and liver functions. Taken as a daily supplement, oat could act as an adjuvant therapy for metabolic disorders.

Keywords

Oat Obesity Abdominal body fat Fatty liver 

Abbreviation

ALT

Alanine transaminase

AST

Aspartate transaminase

BMI

Body mass index

BUN

Blood urea nitrogen

FFA

Free fatty acids

FS

Fatty liver scores

γ-GT

gamma-glutamyl transpeptidase

HDL-C

High-density lipoprotein cholesterol

LDL-C

Low-density lipoprotein cholesterol

TG

Triacylglycerol

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Hong-Chou Chang
    • 1
  • Chien-Ning Huang
    • 1
    • 2
  • Da-Ming Yeh
    • 3
    • 4
  • Shing-Jung Wang
    • 5
  • Chiung-Huei Peng
    • 6
  • Chau-Jong Wang
    • 7
    • 8
  1. 1.Institute of MedicineChung-Shan Medical UniversityTaichung 402Taiwan
  2. 2.Department of Internal MedicineChung Shan Medical University HospitalTaichung 402Taiwan
  3. 3.School of Medical Imaging and Radiological SciencesChung Shan Medical UniversityTaichung 402Taiwan
  4. 4.Department of Medical ImagingChung Shan Medical University HospitalTaichung 402Taiwan
  5. 5.Division of Research and Development, STANDARD Foods Co.TaipeiTaiwan
  6. 6.Division of Basic Medical ScienceHungkuang University, Number 34Taichung 433Taiwan
  7. 7.Institute of Biochemistry and BiotechnologyChung-Shan Medical UniversityTaichung 402Taiwan
  8. 8.Department of Medical ResearchChung Shan Medical University HospitalTaichung 402Taiwan

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