Plant Foods for Human Nutrition

, Volume 67, Issue 4, pp 415–421

Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females: A Metabolomics Approach

  • David C. Nieman
  • Lynn Cialdella-Kam
  • Amy M. Knab
  • R. Andrew Shanely
Original Paper

Abstract

Red pepper spice (RP) and turmeric (TM) are used as flavorings in foods and for medicinal purposes. Utilizing a randomized, doubled-blinded, placebo-controlled, crossover design (2-week washout), 4-week supplementation with RP (1 g/d) or TM (2.8 g/d) was tested for influences on inflammation and oxidative stress in 62 overweight/obese (body mass index ≥ 27 kg/m2) females (40–75 years) with systemic inflammation (C-reactive protein, CRP ≥ 2 mg/l). Overnight, fasted blood samples were collected pre- and post-supplementation, and analyzed for oxidative stress (F2-isoprostanes, oxidized low density lipoprotein), inflammation (CRP and seven inflammatory cytokines), and metabolic profiles using gas chromatography–mass spectrometry with multivariate partial least square discriminant analysis (PLS-DA). Pre- to post-supplementation measures of inflammation and oxidative stress for both RP and TM did not differ when compared to placebo (all interaction effects, P > 0.05), and global metabolic difference scores calculated through PLS-DA were non-significant (both spices, Q2Y < 0.40). These data indicate that 4-week supplementation with RP or TM at culinary levels does not alter oxidative stress or inflammation in overweight/obese females with systemic inflammation, or cause a significant shift in the global metabolic profile.

Keywords

Capsaicin Curcumin F2-isoprostanes Cytokines Metabolites Augmentation index 

Abbreviations

AIx@75

Augmentation index normalized for a heart rate of 75 beats/min

ANOVA

Analysis of variance

BMI

Body mass index

CRP

C-reactive protein

CV

Coefficient of variance

GC-MS

Gas chromatography mass spectrometry

IL

Interleukin

IFNγ

Interferon gamma

LDL

Low-density lipoprotein

PCA

Principal component analysis

PLS-DA

Partial least square discriminant analysis

RP

Red pepper

TM

Turmeric

TNFα

Tumor necrosis factor alpha

TRPV1

Transient potential receptor vanilloid 1

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • David C. Nieman
    • 1
    • 2
  • Lynn Cialdella-Kam
    • 1
  • Amy M. Knab
    • 1
  • R. Andrew Shanely
    • 1
  1. 1.Human Performance Lab, North Carolina Research CampusAppalachian State UniversityKannapolisUSA
  2. 2.North Carolina Research CampusKannapolisUSA

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