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Plant Foods for Human Nutrition

, Volume 66, Issue 4, pp 363–369 | Cite as

Positive Effects of Astaxanthin on Lipid Profiles and Oxidative Stress in Overweight Subjects

  • Hye Duck Choi
  • Yeo Kyu Youn
  • Wan Gyoon ShinEmail author
ORIGINAL PAPER

Abstract

Astaxanthin, a carotenoid, has antioxidant activity as well as many positive effects, such as anticancer and anti-inflammatory effects. We performed a randomized, double-blind, placebo-controlled study to investigate the effects of astaxanthin on lipid profiles and oxidative stress in overweight and obese adults in Korea. In total, 27 subjects with body mass index >25.0 kg/m2 were enrolled and randomly assigned into two groups administered astaxanthin or placebo capsules for 12 weeks. Total cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB) were measured before and after intervention. Malondialdehyde (MDA), isoprostane (ISP), superoxide dismutase (SOD), and total antioxidant capacity (TAC), as oxidative stress biomarkers, were measured at baseline and at 4, 8, and 12 weeks after intervention. LDL cholesterol and ApoB were significantly lower after treatment with astaxanthin, compared with the start of administration, whereas none of the lipid profiles was changed in the placebo group. At the baseline, all four biomarkers were not significantly different between the two groups. Compared with the placebo group, MDA and ISP were significantly lower, but TAC was significantly higher in the astaxanthin group at 12 weeks. These results suggest that supplementary astaxanthin has positive effects by improving the LDL cholesterol, ApoB, and oxidative stress biomarkers.

Keywords

Astaxanthin Carotenoids Lipid profiles Overweight Oxidative stress 

Abbreviations

ApoA1

Apolipoprotein A1

ApoB

Apolipoprotein B

BMI

Body mass index

HDL

High-density lipoprotein

ISP

Isoprostane

LDL

Low-density lipoprotein

LPs

Lipid profiles

MDA

Malondialdehyde

OS

Oxidative stress

SD

Standard deviation

SOD

Superoxide dismutase

TAC

Total antioxidant capacity

Notes

Acknowledgments

This work was supported by a grant of the Korea Health 21 R&D project, Ministry of Health and Welfare, South Korea (A050376). The authors would like to thank all subjects participated in this study. No writing assistance was acquired for this paper. The contributions of the authors to the manuscript are as follows. H.C.: study design, data collection, samples analyses, data analyses and writing of the manuscripts; Y.Y.: study design and coordination; W.S.: study design, coordination and reviewing the manuscript. All authors read and approved the final manuscript.

Disclosure

The authors declared no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Hye Duck Choi
    • 1
  • Yeo Kyu Youn
    • 2
  • Wan Gyoon Shin
    • 1
    Email author
  1. 1.College of Pharmacy and Research Institute of Pharmaceutical SciencesSeoul National UniversitySeoulSouth Korea
  2. 2.Department of Surgery, Seoul National University College of Medicine, Clinical Reseasch InstituteSeoul National University HospitalSeoulSouth Korea

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