Plant Foods for Human Nutrition

, Volume 65, Issue 2, pp 146–151 | Cite as

Effect of Diet Supplemented with Quinoa Seeds on Oxidative Status in Plasma and Selected Tissues of High Fructose-Fed Rats

  • Pawel Pasko
  • Henryk Barton
  • Pawel Zagrodzki
  • Aleksandra Izewska
  • Miroslaw Krosniak
  • Malgorzata Gawlik
  • Maciej Gawlik
  • Shela Gorinstein
Original Paper

Abstract

Oxidative stress plays an important role as a mediator of damage produced by fructose metabolism. This work was designed to investigate the effect of diet supplemented with quinoa seeds on oxidative stress in plasma, heart, kidney, liver, spleen, lung, testis and pancreas of fructose administered rats. Fructose administration (310 g/kg fodder for 5 weeks) caused oxidative stress that was manifested by the increase in plasma malondialdehyde (MDA) (p<0.05), and by the non-significant changes in the enzymatic antioxidant potential in plasma and most of tissues. Co-administration of quinoa seeds (310 g/kg fodder) maintained normal activities of some enzymes. It also influenced the oxidative stress as was evidenced by decreasing MDA in plasma, and decreasing the activities of antioxidant enzymes (erythrocyte superoxide dismutase - eSOD, catalase -CAT, plasma glutathione peroxidase - pGPX). These findings demonstrate that quinoa seeds can act as a moderate protective agent against potential of fructose-induced changes in rats by reducing lipid peroxidation and by enhancing the antioxidant capacity of blood (plasma) and heart, kidney, testis, lung and pancreas.

Keywords

Catalase Glutathione peroxidase Malondialdehyde Oxidative status Quinoa seeds Superoxide dismutase 

Abbreviations

CAT

catalase

eSOD

erythrocyte superoxide dismutase

GPX

glutathione peroxidase

FRAP

ferric reducing ability of plasma

MDA

malondialdehyde

pGPX

plasma glutathione peroxidase

SOD

superoxide dismutase

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Pawel Pasko
    • 1
  • Henryk Barton
    • 1
  • Pawel Zagrodzki
    • 1
    • 2
  • Aleksandra Izewska
    • 1
  • Miroslaw Krosniak
    • 1
  • Malgorzata Gawlik
    • 3
  • Maciej Gawlik
    • 3
  • Shela Gorinstein
    • 4
  1. 1.Department of Food Chemistry and Nutrition, Medical CollegeThe Jagiellonian UniversityKrakówPoland
  2. 2.Department of Nuclear Physical ChemistryHenryk Niewodniczański Institute of Nuclear PhysicKrakówPoland
  3. 3.Department of Toxicology, Medical CollegeThe Jagiellonian UniversityKrakówPoland
  4. 4.Department of Medicinal Chemistry and Natural Products, School of PharmacyThe Hebrew University—Hadassah Medical SchoolJerusalemIsrael

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