Antiproliferative Activity of Korean Wild Vegetables on Different Human Tumor Cell Lines

  • Buk-Gu Heo
  • Sang-Uk Chon
  • Yun-Jum Park
  • Jong-Hyang Bae
  • Su-Min Park
  • Yong-Seo Park
  • Hong-Gi Jang
  • Shela Gorinstein
Original Paper


This study was conducted to determine the antiproliferative activity of 24 Korean wild vegetables. The methanol extracts of these wild vegetables were used against lung, breast, colon and gastric cancer cells, and the results were assessed by MTT assay. It was found that at the extract concentration of 400 mgL−1 14 plants exercised antiproliferative activity over 80% against the lung cancer cells, one plant among six—against breast cancer cells, and two plants among six—against colon cancer cells, respectively. Eighteen wild vegetables had the hyperplasia inhibition activity against gastric cancer cells over 23.6% at all extract concentrations, however, only six plants had the antiproliferative activity over 80% in 600 mgL−1. It was found that the extracts from Youngia sonchifolia, Synurus deltoides, Syneilesis palmata, and Cephalonoplos segetum, in concentration of 400 mgL−1 inhibited the hyperplasia of lung cancer cells over 95% and Angelica gigas—both lung and colon cancer cells over 95%. In conclusion, the studied wild vegetables’ methanol extracts possess dose dependent antiproliferative properties, based on their bioactive compounds, mainly polyphenols, but some of them as Hypericum ascyron against lung cancer are not effective and even course harm.


Korean wild vegetables Methanol extracts Antiproliferative activity 



human pulmonary carcinoma—human cancer cell line


fetal bovine serum


human colon carcinoma—human cancer cell line

MTT (3-(4, 5-dimethylthiazol -2-yl)-2, 5-diphenyltetrazolium bromide)

assay for determination of anticancer activity


drug-activated gene


human breast carcinoma—human cancer cell line


diterpenoid pseudolaric acid B


poly ADP-ribose polymerase

RPMI 1640

A medium developed by Poswell Park Memorial Institute and used for the culture of human normal and neoplastic leukocytes


human gastric carcinoma—human cancer cell line



This research was supported by the Wonkwang University research Grants in 2009.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Buk-Gu Heo
    • 1
  • Sang-Uk Chon
    • 2
  • Yun-Jum Park
    • 3
  • Jong-Hyang Bae
    • 3
  • Su-Min Park
    • 3
  • Yong-Seo Park
    • 4
  • Hong-Gi Jang
    • 1
  • Shela Gorinstein
    • 5
  1. 1.Naju Foundation of Natural Dyeing CultureNajuSouth Korea
  2. 2.EFARINET Co. Ltd., BI CenterChosun UniversityGwangjuSouth Korea
  3. 3.Division of Horticulture and Pet Animal-Plant ScienceWonkwang UniversityIksanSouth Korea
  4. 4.Department of Horticultural ScienceMokpo National UniversityMuanSouth Korea
  5. 5.Department of Medicinal Chemistry and Natural Products, School of PharmacyThe Hebrew University- Hadassah Medical SchoolJerusalemIsrael

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