Abstract
This study investigated whether the consumption of a diet in which high-β-glucan barley replaced rice would reduce the visceral fat area as well as the serum low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) in hypercholesterolemic Japanese men. A randomized, double-blinded, placebo-controlled intervention study was conducted in 44 hypercholesterolemic Japanese men with a body mass index (BMI) >22 kg/m2. The subjects were randomly assigned to groups consuming either rice (placebo group) or a mixture of rice and pearl barley with a high β-glucan content (test group, 7.0 g β-glucan per day) for 12 weeks. Blood samples were taken, and CT scan obtained before the trial and every four weeks during the trial. The pearl barley intake significantly reduced serum concentrations of LDL-C (P = 0.041) and TC (P = 0.037) during the trial. Significant differences between the test and placebo groups were found for the visceral fat (P = 0.039), BMI (P = 0.015), and waist circumference (P = 0.011) at the end point. The consumption of pearl barley with a high β-glucan content reduces not only LDL-C but also visceral fat area.
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Abbreviations
- BMI:
-
body mass index
- LDL-C:
-
low-density lipoprotein cholesterol
- TC:
-
total cholesterol
- HDL-C:
-
high-density lipoprotein cholesterol
- TG:
-
triglyceride
References
FDA (2006) FDA Talk Paper. FDA allows whole barley foods to make health claim on reducing the risk of heart disease. Available at: http://www.fda.gov/bbs/topics/NEWS/2006/NEW01375.html
Aoe S, Itagaki Y, Hatamoto F, Ishii I, Oda T, Suzuki Y, Toba Y, Fujita T, Kinoshita S, Uchida T, Akehara I, Kondo A (2003) Effect of oatmeal cookies supplementation on serum cholesterol levels in Japanese men with boundary and mild hypercholesterolemia: Evaluation of Efficacy and Safety. J Jpn Assoc Dietary Fiber Res 7:26–38
Behall KM, Scholfield DJ, Hallfrisch J (2004) Diets containing barley significantly reduce lipids in mildly hypercholesterolemic men and women. Am J Clin Nutr 80:1185–1193
Davy BM, Davy KP, Ho RC, Beske SD, Davrath LR, Melby CL (2002) High-fiber oat cereal compared with wheat cereal consumption favorably alters LDL-cholesterol subclass and particle numbers in middle-aged and older men. Am J Clin Nutr 76:351–358
Ikegami S, Tomita M, Honda S, Yamaguchi M, Mizukawa R, Suzuki Y, Ishii K, Ohsawa S, Kiyooka N, Higuchi M, Kobayashi S (1996) Effect of barley-rice-feeding in hypercholesterolemic and normolipemic subjects. Plant Food Hum Nutr 49:317–328
Fastnaught CE, Berglund PT, Holm ET, Fox GJ (1996) Genetic and environmental variation in β-glucan content and quality parameters of barley for food. Crop Sci 36:941–946
Kihara M, Aoe S, Konuki J, Nakayama Y, Araki S, Shimizu C, Nakamura Y, Ito K, Ikegami S (2006) Effects of barley with high β-glucan content on serum and liver cholesterol concentrations in cholesterol-fed rats. In: Proceedings of annual meeting of Japanese Society of Nutrition and Food Science, Shizuoka, pp 66, May 19–21
Ministry of Health, Labour and Welfare (2007) Heisei 17 Year Kokumin Kenko Eiyou-chosa. Available at: http://www.mhlw.go.jp/houdou/2007/05/h0516-3.html
Jenkins DJA, Wolever TMS, Kalmusky J, Gliudici S, Giordano C, Wong GS, Bird JN, Patten R, Hall M, Buckley G, Little JA (1985) Low glycemic index carbohydrate foods in the management of hyperlipidemia. Am J Clin Nutr 42:604–617
Schneeman BO (1998) Dietary fiber and gastrointestinal function. Nutr Res 18:625–632
Lia A, Hallmans G, Sandberg AS, Sundberg B, Aman P, Andersson H (1995) Oat beta-glucan increases bile acid excretion and a fiber-rich barley fraction increases cholesterol excretion in ileostomy subjects. Am J Clin Nutr 62:1245–1251
Marlett JA (1997) Sites and mechanisms for the hypocholesterolemic actions of soluble dietary fiber sources. Adv Exp Med Biol 427:109–121
Japanese Ministry of Health, Labour and Welfare (2006) Kenkodukuri no tameno Undo Shishin 2006. Available at: http://www.mhlw.go.jp/bunya/kenkou/undou.html
Lierz G, Mathers JC, Seal CJ (2002) Effect of barley beta-glucan on plasma cholesterol may depend on apolipoprotein E4 genotype—results from a pilot study. Proc Nutr Soc Lond 61:127A
Shimizu T (2003) Health claims on function foods: the Japanese regulations and an international comparison. Nutr Res Rev 16:241–252
Ota N, Soga S, Shimotoyodome A, Haramizu S, Inaba M, Murase T, Tokimitsu I (2005) Effects of combination of regular exercise and tea catechins intake on energy expenditure in humans. J Health Sci 51:233–236
Takao I, Fujii S, Ishii A, Han L, Kumao T, Ozaki K, Asakawa A (2006) Effects of mannooligosaccharides from coffee mannan on fat storage in mice fed a high fat diet. J Health Sci 52:333–337
Acknowledgments
We thank Yukari Ono (Mediscience Planning Inc.) and Tomomi Kumashiro (PS Clinic) for helping the management of the trial. We also thank Norihiko Tsuchimoto (Sapporo Breweries Ltd.) for preparing retort-packed diets.
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Shimizu, C., Kihara, M., Aoe, S. et al. Effect of High β-Glucan Barley on Serum Cholesterol Concentrations and Visceral Fat Area in Japanese Men—A Randomized, Double-blinded, Placebo-controlled Trial. Plant Foods Hum Nutr 63, 21–25 (2008). https://doi.org/10.1007/s11130-007-0064-6
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DOI: https://doi.org/10.1007/s11130-007-0064-6