Biological Activities of Extracts from Sumac (Rhus spp.): A Review
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Abstract
Sumac is the common name for a genus (Rhus) that contains over 250 individual species of flowering plants in the family Anacardiaceae. These plants are found in temperate and tropical regions worldwide, often grow in areas of marginal agricultural capacity, and have a long history of use by indigenous people for medicinal and other uses. The research efforts on sumac extracts to date indicate a promising potential for this plant family to provide renewable bioproducts with the following reported desirable bioactivities: antifibrogenic, antifungal, antiinflammatory, antimalarial, antimicrobial, antimutagenic, antioxidant, antithrombin, antitumorigenic, antiviral, cytotoxic, hypoglycaemic, and leukopenic. As well, the bioactive components can be extracted from the plant material using environmentally benign solvents that allow for both food and industrial end-uses. The favorable worldwide distribution of sumac also suggests that desirable bioproducts may be obtained at the source, with minimal transportation requirements from the source through processing to the end consumer. However, previous work has focussed in just a few members of this large plant family. In addition, not all of the species studied to date have been fully characterized for potential bioactive components and bioactivities. Thus, there remains a significant research gap spanning the range from lead chemical discovery through process development and optimization in order to better understand the full potential of the Rhus genus as part of global green technology based on bioproducts and bioprocesses research programs.
Keywords
Biological activities Extracts Rhus spp. Sumac Bioproducts Antiinflammatory Antioxidant Antimicrobial NutraceuticalsNotes
Acknowledgements
We thank the Natural Sciences and Engineering Research Council (NSERC) of Canada for financial support.
References
- 1.Clark JH (1999) Green chemistry: challenges and opportunities. Green Chem 1:1–8CrossRefGoogle Scholar
- 2.Clark JH (2006) Green chemistry: today (and tomorrow). Green Chem vol. 8. 17–21CrossRefGoogle Scholar
- 3.Clark JH, Budarin V, Deswarte FEI, Hardy JJE, Kerton FM, Hunt AJ, Luque R, Macquarrie DJ, Milkowski K, Rodriguez A, Samuel O, Tavener SJ, White RJ, Wilson AJ (2006) Green chemistry and the biorefinery: a partnership for a sustainable future. Green Chem 8:853–860CrossRefGoogle Scholar
- 4.Mestres R (2004) A brief structured view of green chemistry issues. Green Chem 6:G10–G12CrossRefGoogle Scholar
- 5.Tang SLY, Smith RL, Poliakoff M (2005) Principles of green chemistry. Green Chem 7:761–762CrossRefGoogle Scholar
- 6.Raston C (2005) Renewables and green chemistry. Green Chem 7:57CrossRefGoogle Scholar
- 7.Cacace JE, Mazza G (2006) Pressurized low polarity water extraction of lignans from whole flaxseed. J Food Engr 77:1087–1095CrossRefGoogle Scholar
- 8.Ignaciuk A, Vöhringer F, Ruijs A, van Ierland EC (2004) Competition between biomass and food production in the presence of energy policies: a partial equilibrium analysis. Energy Policy 34:1127–1138CrossRefGoogle Scholar
- 9.Berndes G (2006) The contribution of renewables to society. In: Dewulf J, Van Langenhove H (eds) Renewables-Based Technology. John Wiley & Sons, New York, NY, USA, pp. 3–18Google Scholar
- 10.Perlack RD (2006) Biomass as feedstock for a bioenergy and bioproducts industry: The technical feasability of a billion-ton annual supply. United States Department of Energy, Washington, DC, USAGoogle Scholar
- 11.USDA (2007) Germplasm Resources Information Network. Beltsville, MD, USA: United States Department of Agriculture, Agricultural Research Service. http://www.ars-grin.gov/npgs/aboutgrin.html
- 12.Van Wyk BE, Wink M (2004) Medicinal plants of the world. Timber Press, Portland, OR, USAGoogle Scholar
- 13.Erichsen-Brown C (1989) Medicinal and Other Uses of North American Plants: A Historical Survey with Special Reference to the Eastern Indian Tribes. New York, NY, USA: Dover PublicationsGoogle Scholar
- 14.Sezik E, Tabata M, Yesilada E (1991) Traditional medicine in Turkey. 1. Folk medicine in northeast Anatolia. J Ethnopharmacol 35:191–196CrossRefGoogle Scholar
- 15.McCutcheon AR, Ellis SM, Hancock RE, Towers GH (1992) Antibiotic screening of medicinal plants of the British Columbian native peoples. J Ethnopharmacol 37:213–223CrossRefGoogle Scholar
- 16.McCutcheon AR, Ellis SM, Hancock RE, Towers GH (1994) Antifungal screening of medicinal plants of British Columbia native peoples. J Ethnopharmacol 44:157–169CrossRefGoogle Scholar
- 17.Saxena G, McCutcheon AR, Farmer S (1994) Antimicrobial constituents of Rhus glabra. J Ethnopharmacol 42:95–99CrossRefGoogle Scholar
- 18.Nimri LF, Meqdam MM, Alkofahi A (1999) Antibacterial activity of Jordanian medicinal plants. Pharm Biol 37:196–201Google Scholar
- 19.Nasar-Abbas SM, Halkman AK (2004) Inhibition of some foodborne bacteria by alcohol extract of sumac (Rhus coriaria L.). J Food Safety 24:257–267CrossRefGoogle Scholar
- 20.Adwan G, Abu-Shanab B, Adwan K, Abu-Shanab F (2006) Antibacterial effects of nutraceutical plants growing in Palestine on Pseudomonas aeruginosa. Turk J Biol 30:239–242Google Scholar
- 21.Fazeli MR, Amin G, Attari MMA, Ashtiani H, Jamalifar H, Samadi N (2007) Antimicrobial activities of Iranian sumac and avish-e shirazi (Zataria multiflora) against some food-borne bacteria. Food Contr 18:646–649CrossRefGoogle Scholar
- 22.Nasar-Abbas SM, Halkman AK (2004) Antimicrobial effect of water extract of sumac (Rhus coriaria L.) on the growth of some food borne bacteria including pathogens. Int J Food Microbiol 97:63–69CrossRefGoogle Scholar
- 23.Gulmez M, Oral N, Vatansever L (2006) The effect of water extract of sumac (Rhus coriaria L.) and lactic acid on decontamination and shelf life of raw broiler wings. Poultry Sci 85:1466–1471Google Scholar
- 24.Sagdic O, Ozcan M (2003) Antibacterial activity of Turkish spice hydrosols. Food Control 14:141–143CrossRefGoogle Scholar
- 25.Lin YM, Flavin MT, Schure R, Chen FC, Sidwell R, Barnard DL, Huffman JH, Kern ER (1999) Antiviral activities of bioflavonoids. Planta Med 65:120–125CrossRefGoogle Scholar
- 26.Ahmed MS, Galal AM, Ross SA, Ferreira D, Elsohly MA, Ibrahim AS, Mossa JS, El-Feraly FS (2001) A weakly antimalarial biflavanone from Rhus retinorrhoea. Phytochemistry 58:599–602CrossRefGoogle Scholar
- 27.Bagchi A, Sahai M, Ray AB (1985) Phenolic constituents of Rhus semialata leaves. Planta Med 51:467–468CrossRefGoogle Scholar
- 28.Pokorny J (1991) Natural antioxidants for food use. Trends Food Sci Technol 2:223–227CrossRefGoogle Scholar
- 29.Lee JC, Kim J, Lim KT, Yang MS, Jang YS (2001) Ethanol eluted extract of Rhus verniciflua Stokes showed both antioxidant and cytotoxic effects on mouse thymocytes depending on the dose and time of the treatment. J Biochem Mol Biol 34:250–258Google Scholar
- 30.Lee JC, Lim KT, Jang YS (2002) Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. Biochem Biophys Acta 1570:181–191Google Scholar
- 31.Young DA (1976) Flavonoid chemistry and the phylogenetic relationships of the Julianiaceae. Syst Bot 1:149–162CrossRefGoogle Scholar
- 32.Keppler HH (1957) The isolation and constitution of molisacacidin, a new leucoanthocyanidin from the heartwood of Acacia mollisima. J Chem Soc 2721–2724Google Scholar
- 33.Yasue M, Kato Y (1957) Components of wood of Rhus trichocarpa. Yakugaku Zasshi 77:1045–1047Google Scholar
- 34.Van Loo P, De Bruyn A, Verzelel M (1988) On the liquid chromatography and identification of the flavonoids present in the “sumach tannic acid” extracted from Rhus coriaria. Chromatographia 25:15–20CrossRefGoogle Scholar
- 35.Bate-Smith EC (1962) The phenolic constituents of plants and their taxonomic significance. I. Dicotyledons. J Linn Soc (Bot) 58:95–173CrossRefGoogle Scholar
- 36.Plouvier V (1970) Structure of flavone glycosides by nuclear magnetic resonance. Compounds of the genera Centaurea, Kerria, Rhus, and Scabiosa. CR Acad Sci (Paris) 270:2710–2713Google Scholar
- 37.Kitts DD, Lim KT (2001) Antitumorigenic and cytotoxic properties of an ethanol extract derived from Rhus verniciflua Stokes (RVS). J Toxicol Environ Health, Part A 64:357–371CrossRefGoogle Scholar
- 38.Park YS, Kim YS, Shin DH (2002) Antioxidative effects of ethanol extracts from Rhus vernicifera Stoke on yukwa (oil popped rice snack) base during storage. J Food Sci 67:2474–2479CrossRefGoogle Scholar
- 39.Ozcan M, Akgul A (1995) Antioxidant activity of extracts and essential oils from turkish spices on sunflower oil. Acta Alimentaria 24:81–90Google Scholar
- 40.Ozcan M (2003) Effect of sumach (Rhus coriaria L.) extracts on the oxidative stability of peanut oil. J Med Food 6:63–66CrossRefGoogle Scholar
- 41.Ozcan M (2003) Antioxidant activities of rosemary, sage, and sumac extracts and their combinations on stability of natural peanut oil. J Med Food 6:267–270CrossRefGoogle Scholar
- 42.Bozan B, Kosar M, Tunalier Z, Ozturk N, Baser KHC (2003) Antioxidant and free radical scavenging activities of Rhus coriaria and Cinnamomum cassia extracts. Acta Alimentaria 32:53–61CrossRefGoogle Scholar
- 43.Candan F (2003) Effect of Rhus coriaria L. (Anacardiaceae) on superoxide radical scavenging and xanthine oxidase activity. J Enzyme Inhib Med Chem 18:59–62CrossRefGoogle Scholar
- 44.Candan F, Sokmen A (2004) Effects of Rhus coriaria L. (Anacardiaceae) on lipid peroxidation and free radical scavenging activity. Phytother Res 18:84–86CrossRefGoogle Scholar
- 45.Bozkurt H (2006) Investigation of the effect of sumac extract and BHT addition on the quality of sucuk (Turkish dry-fermented sausage). J Sci Food Agric 86:849–856CrossRefGoogle Scholar
- 46.McCune LM, Johns T (2002) Antioxidant activity in medicinal plants associated with the symptoms of diabetes mellitus used by the Indigenous Peoples of the North American boreal forest. J Ethnopharmacol 82:197–205CrossRefGoogle Scholar
- 47.Wu PL, Lin SB, Huang CP, Chiou RYY (2002) Antioxidative and cytotoxic compounds extracted from the sap of Rhus succedanae. J Nat Prod 65:1719–1721CrossRefGoogle Scholar
- 48.Kuo SC, Teng CM, Lee LG, Chiu TH, Wu TS, Huang SC, Wu JB, Shieh TY, Chang RJ, Chou TC (1991) 6-Pentadecylsalicylic acid: An antithrombin component isolated from the stem of Rhus semialata var. roxburghii. Planta Med 57:247–249CrossRefGoogle Scholar
- 49.Lee SH, Nan JX, Zhao YZ, Woo SW, Park EJ, Kang TH, Seo GS, Kim YC, Sohn DH (2003) The chalcone butein from Rhus verniciflua shows antifibrogenic activity. Planta Med 69:990–994CrossRefGoogle Scholar
- 50.Fourie TG, Snyckers FO (1984) A flavone with antiinflammatory activity from the roots of Rhus undulate. J Nat Prod 47:1057–1058CrossRefGoogle Scholar
- 51.Giancarlo S, Rosa ML, Nadjafi F, Francesco M (2006) Hypoglycaemic activity of two spices extracts: Rhus coriaria L. and Bunium persicum Boiss. Nat Prod Res 20:882–886CrossRefGoogle Scholar
- 52.Park KY, Jung GO, Lee KT, Choi J, Choi MY, Kim GT, Jung HJ, Park HJ (2004) Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. J Ethnopharmacol 90:73–79CrossRefGoogle Scholar
- 53.Oshima R, Kumanotani J (1984) Structural studies of plant gum from sap of the lac tree, Rhus vernicifera. Carb Res 127:43–57CrossRefGoogle Scholar
- 54.Du Y, Kong Z, Li H (1994) Studies on separation and structure of lacquer polysaccharide. Acta Polymerica Sinica 3:301–306Google Scholar
- 55.Du Y, Yang J, Kong Z, Xiao L (1999) Structure and bioactivities of lacquer polysaccharides from Chinese lac trees of wild species and cultispecies. Chem J Chin Univ 20:399–402Google Scholar
- 56.Yang J, Du Y (2003) Sulfation of Chinese lacquer polysaccharides in different solvents. Carb Polym 52:405–410CrossRefGoogle Scholar
- 57.Son YO, Lee KY, Lee JC, Jang HS, Kim JG, Jeon YM, Jang YS (2005) Selective antiproliferative and apoptotic effects of flavonoids purified from Rhus verniciflua Stokes on normal versus transformed hepatic cell lines. Toxicol Lett 155:115–125CrossRefGoogle Scholar
- 58.Lee JC, Lee KY, Kim J, Na CS, Jung NC, Chung GH, Jang YS (2004) Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells. Food Chem Toxicol 42:1383–1388CrossRefGoogle Scholar