Exploring the Link Between Posttraumatic Stress Disorder and inflammation-Related Medical Conditions: An Epidemiological Examination
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There have been few epidemiological studies exploring the link between PTSD and inflammation using population-based samples. This study examined the relation between posttraumatic stress disorder (PTSD) and inflammation-related medical conditions using data from the 2013–2014 New York City Health and Nutrition Examination Survey. Using a representative sample of 1,527 residents in New York City, the association between PTSD and 17 inflammation-related medical conditions were examined. Bivariate and multivariable analyses were conducted, adjusting for demographic characteristics and lifetime depression. PTSD was strongly associated with increased odds for hypercholesterolemia, insulin resistance, angina, heart attack, and emphysema with the greatest odds observed for heart attack (OR= 3.94) and emphysema (OR= 4.06). But PTSD was also associated with lower odds for hypertension, type 1 diabetes, asthma, coronary heart disease, stroke, osteoporosis, and a failing kidney with the lowest odds observed for type 1 diabetes (OR= 0.43). These findings suggest a complex link between PTSD and inflammation-related medical conditions.
KeywordsPosttraumatic stress disorder Inflammation Cardiovascular diseases Pulmonary diseases
We thank the CUNY School of Public Health and NYC Department of Health for their development of the NYC HANES initiative.
Compliance with Ethical Standards
There was no direct funding for this study.
Conflict of Interest
Dr. Tsai and Mr. Shen declares that they have no conflict of interest with this work.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study by the original principal investigators of the NYC HANES initiative.
- 2.Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: Results from the National Health and Resilience in Veterans Study. Journal of Clinical Psychiatry. 2014;76(5):546–53.Google Scholar
- 3.Sledjeski EM, Speisman B, Dierker LC. Does number of lifetime traumas explain the relationship between PTSD and chronic medical conditions? Answers from the National Comorbidity Survey-Replication (NCS-R). J Behav Med. 2008;31(4):341–9. doi: 10.1007/s10865-008-9158-3 CrossRefPubMedPubMedCentralGoogle Scholar
- 11.von Känel R, Begré S, Abbas CC, Saner H, Gander ML, Schmid JP. Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms. Neuroimmunomodulation. 2009;17(1):39–46.Google Scholar
- 17.Sautter FJ, Bissette G, Wiley J, Manguno-Mire G, Schoenbachler B, Myers L, et al. Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects. Biol Psychiatry. 2003;54(12):1382–8.CrossRefPubMedGoogle Scholar
- 19.Thorpe LE, Greene C, Freeman A, Snell E, Rodriguez-Lopez JS, Frankel M, et al. Rationale, design and respondent characteristics of the 2013-2014 New York City Health and Nutrition Examination Survey (NYC HANES 2013-2014). Prev Med Rep. 2015;2:580–5. doi: 10.1016/j.pmedr.2015.06.019 CrossRefPubMedPubMedCentralGoogle Scholar
- 20.U.S. Census Bureau. American Community Survey. U.S. Census Bureau, Washington, DC. 2013. http://www.census.gov/acs/www/data/data-tables-and-tools/data-profiles/2013/. Accessed December 10 2016.