Oxytocin and Social Cognitions in Schizophrenia: A Systematic Review
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Schizophrenia is a chronic multifactorial disorder. Over the last years, there has been a growing interest in cognitive deficits in schizophrenia, which is considered by many as the core abnormality of the disease. In the systematic review we focus on the social cognition and its correlation with the neuropeptide oxytocin, which is shown to be involved in the emotion recognizing processes, in the trust behavior and many other aspects of social functioning. The systematic review was performed in order to summarize the data on the liaison of oxytocin with the social cognition impairment in schizophrenia patients. Oxytocin is assumed to be a potential therapeutic agent for schizophrenia, with a special link to social cognitive functions. The oxytocinergic system is a promising neuromodulator of emotion recognition that may have the potential to normalize the social dysfunction seen in schizophrenia. Further studies are required to provide more data on the correlations between oxytocin and socialcognition as well as other schizophrenia symptoms.
KeywordsOxytocin Schizophrenia Cognition
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Conflict of Interest
The authors declare that the review was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors alone are responsible for the content and writing of the paper.
- 10.Cacciotti-Saija C, Langdon R, Ward PB, Hickie IB, Scott EM, Naismith SL, Moore L, Alvares GA, Redoblado Hodge MA, Guastella AJ: A double-blind randomized controlled trial of oxytocin nasal spray and social cognition training for young people with early psychosis. Schizophrenia Bulletin 41:483–493, 2014.CrossRefPubMedPubMedCentralGoogle Scholar
- 18.American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Association, Washington, DC, 2013.Google Scholar
- 36.Kiss A, Mikkelsen JD: Oxytocin–anatomy and functional assignments: A minireview. Endocrine Regulations 39:97–105, 2005.Google Scholar
- 51.Pedersen CA, Rau S, Salimi K, Gibson C, Leserman J, Penn D: Oxytocin treatment improves social cognition and reduces psychotic symptoms in schizophrenia (poster); Paper presented at the American College of Neuropsychopharmacology.Google Scholar
- 53.Perez-Rodriguez MM, Mahon K, Russo M, Ungar AK, Burdick KE: Oxytocin and social cognition in affective and psychotic disorders. European Neuropsychopharmacology 25:265–282, 2015.Google Scholar
- 63.Van IJzendoorn MH, Bakermans-Kranenburg MJ: A sniff of trust: Meta-analysis of the effects of intranasal oxytocin administration on face recognition, trust to in-group, and trust to out-group. Psychoneuroendocrinology 37:438–443, 2012.Google Scholar
- 65.Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jonsson B,Olesen J, Allgulander C, Alonso J, Faravelli C, Fratiglioni L, Jennum P, Lieb R, Maercker A, Van Os J, Preisig M, Salvador-Carulla L, Simon R, Steinhausen HC: The size and burden of mental disorders and other disorders of the brain in Europe. European Neuropsychopharmacology 21:655–679.CrossRefPubMedGoogle Scholar