Psychiatric Quarterly

, Volume 83, Issue 3, pp 311–324

Cognitive Efficacy of Quetiapine in Early-Onset First-Episode Psychosis: A 12-Week Open Label Trial

  • Sébastien Urben
  • Pierre Baumann
  • Sandra Barcellona
  • Muriel Hafil
  • Ulrich Preuss
  • Claire Peter-Favre
  • Stéphanie Clarke
  • Olivier Halfon
  • Laurent Holzer
Original Paper

DOI: 10.1007/s11126-011-9201-3

Cite this article as:
Urben, S., Baumann, P., Barcellona, S. et al. Psychiatr Q (2012) 83: 311. doi:10.1007/s11126-011-9201-3

Abstract

Twenty-three adolescents with psychotic disorders, aged from 13 to 18 years, participated in a 12-week open label trial (17 adolescents completed the study) in order to examine the impact of quetiapine on clinical status and cognitive functions (encompassing processing speed, attention, short-term memory, long-term memory and executive function). An improvement in Clinical Global Impression and Positive and Negative Symptom Scale (P’s ≤ 0.001) was observed. In addition, after controlling for amelioration of symptoms, a significant improvement was observed on one executive function (P = 0.044; Trail Making Part B). The remaining cognitive abilities showed stability. In addition, we observed an interaction between quetiapine doses (>300 mg/day or <300 mg/day) and time, where lower doses showed more improvement in verbal short-term memory (P = 0.048), inhibition abilities (P = 0.038) and positive symptoms (P = 0.020). The neuropsychological functioning of adolescents with psychotic disorders remained mainly stable after 12 weeks of treatment with quetiapine. However, lower doses seemed to have a better impact on two components of cognition (inhibition abilities and verbal short-term memory) and on positive symptoms.

Keywords

Schizophrenia Psychosis Adolescence Cognition Neuropsychology Quetiapine Antipsychotic treatment Cognitive enhancer 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sébastien Urben
    • 1
  • Pierre Baumann
    • 2
  • Sandra Barcellona
    • 3
  • Muriel Hafil
    • 3
  • Ulrich Preuss
    • 6
    • 7
  • Claire Peter-Favre
    • 4
  • Stéphanie Clarke
    • 4
  • Olivier Halfon
    • 5
  • Laurent Holzer
    • 3
  1. 1.Unité de Recherche, Service Universitaire de Psychiatrie de l’Enfant et de l’Adolescent (SUPEA)Centre Hospitalier Universitaire Vaudois (CHUV)LausanneSwitzerland
  2. 2.Département de PsychiatrieCHUVPrilly-LausanneSwitzerland
  3. 3.Centre Thérapeutique de Jour pour Adolescents, SUPEACHUVLausanneSwitzerland
  4. 4.Division de NeuropsychologieCHUVLausanneSwitzerland
  5. 5.SUPEACHUVLausanneSwitzerland
  6. 6.Kinder und Jugendpsychiatrische PoliklinikBernSwitzerland
  7. 7.Klinik für Kinder- und JugendpsychiatrieBrandenburgGermany

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