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Psychiatric Quarterly

, Volume 83, Issue 2, pp 177–185 | Cite as

Bupropion Versus Sertraline in the Treatment of Depressive Patients with Binge Eating Disorder: Retrospective Cohort Study

  • Carmela Calandra
  • Rina Giuseppa Russo
  • Maria Luca
Original Paper

Abstract

This study sought to compare Bupropion versus Sertraline in the treatment of depressed patients with Binge Eating Disorder (BED) prescribed off-label. Medical records of outpatients with diagnosis of BED and Depression (DSM-IV-TR criteria) were selected: 15 patients were treated with bupropion 150 mg/per day, and 15 with sertraline 200 mg/per day. During the screening and control visits (2°–6°–14°–24° week), the selected patients were first weighed and then evaluated using the following questionnaires: Binge Eating Disorder-Clinical Interview (BEDCI), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory X (STAI-X) and Arizona Sexual Experience Scale (ASEX). Both drugs reduced anxious-depressive symptoms and binge frequency: Bupropion showed a better effectiveness in reducing weight and improving sexual performances; weight loss related to it was proportional to the body mass index. Bupropion may be associated with more weight loss in BED, depressed patients than sertraline.

Keywords

Binge Eating Disorder Depression Body Mass Index Sexual performances 

Notes

Acknowledgments

The authors would like to thank Dr. Antonina Luca from Catania for her precious help in the first review of this article.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Carmela Calandra
    • 1
  • Rina Giuseppa Russo
    • 1
  • Maria Luca
    • 1
  1. 1.Department of Medical and Surgery Specialties, Psychiatry Unit of the University Hospital “Policlinico-Vittorio Emanuele” of CataniaUniversity of CataniaCatania (Sicily)Italy

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