Advertisement

Selective laser sintering/melting of nitinol–hydroxyapatite composite for medical applications

  • I. V. ShishkovskiiEmail author
  • I. A. Yadroitsev
  • I. Yu. Smurov
Theory and Technology of Sintering, Thermal and Chemicothermal Treatment

The layer-by-layer synthesis of 3D parts from nitinol (NiTi intermetallide) and hydroxyapatite additions using selective laser sintering/melting (SLS/SLM) is studied. The effect of different laser parameters on the structure and phase composition of sintered/melted samples is analyzed with optical and scanning electron microscopy, x-ray diffraction, and energy-dispersive x-ray analysis. Optimum SLS/SLM parameters are determined for the synthesis of NiTi + HA to be used in tissue engineering and manufacture of medical devices (pins, nails, porous implants, drug delivery systems). No significant destruction of HA ceramics under laser treatment is observed. The amount of nickel released to the surface of 3D parts decreases owing to the additional oxidation of free titanium during SLS/SLM and the formation of a protective HA layer. Full-density 3D parts are produced from nitinol by SLM including preheating to 300°C.

Keywords

selective laser sintering/melting (SLS/SLM) porous tissue engineering nitinol hydroxyapatite (HA) 

Notes

Acknowledgement

The research has been sponsored through the Russian Fundamental Research Fund (Project No. 10-08-00208-a) and a grant under the Program “Fundamental Sciences for Medicine” (Stages 2009–2011) of the Presidium of the Russian Academy of Sciences.

References

  1. 1.
    I. V. Shishkovsky, D. M. Gureev, and A. L. Petrov, “Formation of intermetallic phases under laser sintering of powdered SHS compositions,” Proc. SPIE, 3688, 237–242 (1999).CrossRefGoogle Scholar
  2. 2.
    I. V. Shishkovskii, L. V. Zhuravel’, A. L. Petrov, and E. Yu. Tarasova, “Synthesis of biocomposite based on NiTi with hydroxyapatite during selective laser sintering,” Pis’ma Zh. Tekh. Fiz., 27, No. 5, 81–86 (2001).Google Scholar
  3. 3.
    I. V. Shishkovsky, L. T. Volova, M. V. Kuznetsov, et al., “Porous biocompatible implants and tissue scaffolds synthesized by selective laser sintering from Ti and NiTi,” J. Mater. Chem., 18, No. 12, 1309–1317 (2008).CrossRefGoogle Scholar
  4. 4.
    S. Shabalovskaya, J. Anderegg, and J. Van Humbeeck, “Critical overview of Nitinol surfaces and their modifications for medical applications,” Acta Biomater., 4, 447–467 (2008).CrossRefGoogle Scholar
  5. 5.
    H. C. Jiang and L. J. Rong, “Effect of hydroxyapatite coating on nickel release of the porous NiTi shape memory alloy fabricated by SHS method,” Surf. Coat. Technol., 201, 1017–1021 (2006).CrossRefGoogle Scholar
  6. 6.
    V. Muhonen, R. Heikkinen, A. Danilov, et al., “The effect of oxide thickness on osteoblast attachment and survival on NiTi alloy,” J. Mater. Sci.: Mater. Med., 18, No. 5, 959–967 (2007).CrossRefGoogle Scholar
  7. 7.
    S. Eosoly, S. Lohfeld, and D. Brabazon, “Effect of hydroxyapatite on biodegradable scaffolds fabricated by SLS,” Key Eng. Mater., 396–398, 659–662 (2009).CrossRefGoogle Scholar
  8. 8.
    R. D. Goodridge, D. J. Wood, C. Ohtsuki, and K. W. Dalgarno, “Biological evaluation of an apatite–mullite glass-ceramic produced via selective laser sintering,” Acta Biomater., 3, 221–231 (2007).CrossRefGoogle Scholar
  9. 9.
    C. K. Chua, K. F. Leong, K. H. Tan, et al., “Development of tissue scaffolds using selective laser sintering of polyvinyl alcohol/hydroxyapatite,” J. Mater. Sci.: Mater. Med., 15, 1113–1121 (2004).CrossRefGoogle Scholar
  10. 10.
    B. Duan, M. Wang, W. Y. Zhou, and W. L. Cheung, “Synthesis of Ca–P nanoparticles and fabrication of Ca–P/PHBV nanocomposite microspheres for bone tissue engineering applications,” Appl. Surf. Sci., 255, 529–533 (2008).CrossRefGoogle Scholar
  11. 11.
    C. Von Wilmowsky, E. Vairaktaris, D. Pohle, et al., “Effects of bioactive glass and β-TCP containing three-dimensional laser sintered polyetheretherketone composites on osteoblasts in vitro,” J. Biomed. Mater. Res., 87, No. 4, 896–902 (2008).CrossRefGoogle Scholar
  12. 12.
    J. L. Arias, M. B. Mayor, F. J. G. A Sanz, et al., “Structural analysis of calcium phosphate coatings produced by pulsed laser deposition at different water-vapor pressures,” J. Mater. Sci.: Mater. Med., 8, 873–876 (1997).CrossRefGoogle Scholar
  13. 13.
    K. W. K. Yeung, R. Y. L. Chan, K. O. Lamand, et al., “In vitro and in vivo characterization of novel plasma treated nickel titanium shape memory alloy for orthopedic implantation,” Surf. Coat. Technol., 202, 1247–1251 (2007).CrossRefGoogle Scholar
  14. 14.
    Z. D. Cui, M. F. Chen, L. Y. Zhang, et al., “Improving the biocompatibility of NiTi alloy by chemical treatments: An in vitro evaluation in 3T3 human fibroblast cell,” Mater. Sci. Eng. C, 28, 1117–1122 (2008).CrossRefGoogle Scholar
  15. 15.
    I. V. Shishkovsky, “Synthesis of functional gradient parts via RP methods,” Rapid Prototyping J., 7, No. 4, 207–211 (2001).CrossRefGoogle Scholar
  16. 16.
    I. Yadroitsev, Ph. Bertrand, B. Laget, and I. Smurov, “Application of laser assisted technologies for fabrication of functionally graded coatings and objects for the international thermonuclear experimental reactor components,” J. Nucl. Mater., 362, 189–196 (2007).CrossRefGoogle Scholar
  17. 17.
    J.-P. Kruth, P. Mercelis, J. Van Vaerenbergh, et al., “Binding mechanisms in selective laser sintering and selective laser melting,” Rapid Prototyping J., 11, 26–36 (2005).CrossRefGoogle Scholar
  18. 18.
    I. V. Shishkovsky, M. V. Kuznetsov, and Yu. G. Morozov, “Porous titanium and nitinol implants synthesized by SHS/SLS: microstructural and histomorphological analyses of tissue reactions,” Int. J. Self-Propag. High-Temp. Synth., 19, No. 2, 157–167 (2010).CrossRefGoogle Scholar
  19. 19.
    I. V. Shishkovskii, Laser Synthesis of Functional Mesostructures and 3D Parts [in Russian], Fizmatgiz, Moscow (2009).Google Scholar
  20. 20.
    H. C. Jiang and L. J. Rong, “Effect of hydroxyapatite coating on nickel release of the porous NiTi shape memory alloy fabricated by SHS method,” Surf. Coat. Technol., 201, 1017–1021 (2006).CrossRefGoogle Scholar
  21. 21.
    F. R. Rose, L. A. Cyster, D. M. Grant, et al., “In vitro assessment of cell penetration into porous hydroxyapatite scaffolds with a central aligned channel,” Biomater., 25, 5507–5514 (2004).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • I. V. Shishkovskii
    • 1
    Email author
  • I. A. Yadroitsev
    • 1
  • I. Yu. Smurov
    • 1
  1. 1.Lebedev Physical Institute, Russian Academy of SciencesSamaraRussia

Personalised recommendations