Zinc deficiency and human health: etiology, health consequences, and future solutions
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Multiple functions in the human body are affected by zinc deficiency. Here the etiology, assessment, health consequences, and intervention strategies for human zinc deficiency are discussed.
A literature review was conducted to identify papers on the topics itemized using electronic databases.
A major factor in the etiology of zinc deficiency is inadequate intakes, followed by physiological states increasing requirements, and pathological conditions resulting in poor absorption, excessive losses, or impaired utilization. High risk groups comprise infants, preschoolers, pregnant and lactating women, and the elderly. Zinc deficiency can result in impairments in growth, immune competence, and reproductive function, leading to increased risk of stunting, diarrhea, respiratory diseases, and mortality during childhood, and preterm births in pregnancy. Intervention strategies include supplementation, fortification, dietary diversification/modification, and biofortification, the choice depending on the magnitude of risk, life-stage group, and setting.
Zinc supplementation is recommended for treating acute diarrhea, and for preventing stunting, diarrhea, pneumonia, and mortality in high risk children. Zinc fortified cereals are appropriate for urban households, whereas dietary diversification/modification and biofortification are suitable for the rural poor. For maximum impact, interventions should be integrated with effective public health programs that address underlying causes of zinc deficiency.
KeywordsSupplementation Fortification Dietary diversification Biofortification Diarrhea Respiratory diseases Children pregnancy Etiological factors
- Arsenault JE, Yakes EA, Hossain MB, Islam MM, Ahmed T, Hotz C, Lewis B, Rahman AS, Jamil KM, Brown KH (2010) The current high prevalence of dietary zinc inadequacy among children and women in rural Bangladesh could be substantially ameliorated by zinc biofortification of rice. J Nutr 140:1683–1690PubMedCrossRefGoogle Scholar
- Brown KH, Hambidge KM, Ranum P, Tyler V, and the Zinc Fortification Working Group (2009c) Zinc fortification for cereal flours. Current recommendations and research needs. Food Nutr Bull 31:S62–S74Google Scholar
- Gibson RS (2005) Principles of nutritional assessment, 2nd edn. Oxford University Press, New YorkGoogle Scholar
- Gibson RS, Anderson VP (2009) A review of interventions based on dietary diversification or modification strategies with the potential to enhance intakes of total and absorbable zinc. Food Nutr Bull 30:S106–S141Google Scholar
- Gibson RS, Ferguson EL (2005) An interactive 24-hour recall for assessing the adequacy of iron and zinc intakes in developing countries. HarvestPLus Technical Monograph Series 8. International Life Sciences Institute, Washington DCGoogle Scholar
- Mahomed K, Bhutta Z, Middleton P (2007) Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev Apr 18;(2) CD000230.Google Scholar
- WHO/UNICEF (2004) Clinical management of acute diarrhoea. WHO/UNICEF, GenevaGoogle Scholar
- WHO/UNICEF/IAEA/IZiNCG (2007) Report of a WHO/UNICEF/IAEA/IZiNCG interagency meeting on zinc status indicators. Food Nutr Bull 28:S399–S483Google Scholar