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Pituitary

, Volume 22, Issue 2, pp 163–169 | Cite as

Filamin A and DRD2 expression in corticotrophinomas

  • Thais Sickler
  • Ericka Barbosa Trarbach
  • Fernando Pereira Frassetto
  • Juliano Bertollo Dettoni
  • Venâncio Avancini Ferreira Alves
  • Maria Candida Barisson Villares Fragoso
  • Marcio Carlos Machado
  • Ellison Fernando Cardoso
  • Marcello Delano Bronstein
  • Andrea GlezerEmail author
Article
  • 45 Downloads

Abstract

Purpose

Filamin A (FLNA) expression is related to dopamine receptor type 2 (DRD2) expression in prolactinomas. Nevertheless, in corticotrophinomas, there are few studies about DRD2 expression and no data on FLNA. Therefore, we evaluated FLNA and DRD2 expression in corticotrophinomas and their association with tumor characteristics.

Methods

DRD2 and FLNA expression by immunohistochemistry, using H-score, based on the percentage of positive cells in a continuous scale of 0–300, were evaluated in 23 corticotrophinomas samples from patients submitted to neurosurgery. In six patients, treatment with cabergoline was indicated after non curative surgery.

Results

Twenty-two patients were female and one male. Regarding tumor size, 10 were micro and 12 were macroadenomas. DRD2 expression was found in 89% of cases and did not correlate with FLNA expression. Moreover, the response to cabergoline, observed in 33% of the cases, did not correlate with DRD2 nor FLNA expression. FLNA expression was not associated with clinical and tumor characteristics, except for sphenoid sinus invasion.

Conclusions

In our cohort of corticotrophinomas, DRD2 expression was not associated with FLNA expression nor to the response to CAB. Nonetheless, FLNA expression could be related to tumor invasiveness.

Keywords

Filamin A DRD2 Corticotrophinomas Cushing’s disease Cabergoline 

Notes

Acknowledgements

We specially thank Alda Wakamatsu for her carefully help in immunohistochemistry reactions. This work was supported by the National Council of Scientific and Technological Development (CNPq), number 162014/2013-9 and Federico Foundation.

Compliance with ethical standards

Conflict of interest

The authors declare that have no conflict of interest.

Ethical approval

This study was approved by the ethics committee and was performed in accordance with the ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Thais Sickler
    • 1
  • Ericka Barbosa Trarbach
    • 1
  • Fernando Pereira Frassetto
    • 2
  • Juliano Bertollo Dettoni
    • 3
  • Venâncio Avancini Ferreira Alves
    • 2
  • Maria Candida Barisson Villares Fragoso
    • 1
  • Marcio Carlos Machado
    • 1
    • 4
  • Ellison Fernando Cardoso
    • 5
  • Marcello Delano Bronstein
    • 1
  • Andrea Glezer
    • 1
    • 6
    Email author
  1. 1.Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas & Laboratory of Cellular and Molecular Endocrinology LIM-25University of Sao Paulo Medical SchoolSão PauloBrazil
  2. 2.Pathology Unit, Hospital das Clínicas & Laboratory of Pathology, LIM-14University of Sao Paulo Medical SchoolSão PauloBrazil
  3. 3.Hospital Universitário Cassiano Antonio de Moraes/UFESVitóriaBrazil
  4. 4.Endocrinology ServiceAC Camargo Cancer CenterSão PauloBrazil
  5. 5.Department of Radiology, LIM-44University of Sao Paulo Medical SchoolSão PauloBrazil
  6. 6.Medical SchoolUniversity of Sao PauloSão PauloBrazil

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