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Pituitary

, Volume 21, Issue 4, pp 393–405 | Cite as

Cystic tumors of the pituitary infundibulum: seminal autopsy specimens (1899 to 1904) that allowed clinical-pathological craniopharyngioma characterization

  • José M. Pascual
  • Ruth Prieto
  • Maria Rosdolsky
  • Sewan Strauss
  • Inés Castro-Dufourny
  • Verena Hofecker
  • Eduard Winter
  • Rodrigo Carrasco
  • Walter Ulrich
Article
  • 108 Downloads

Abstract

A heterogeneous group of epithelial cystic tumors developed at the infundibulum and the third ventricle disconcerted pathologists at the dawn of the twentieth century. Very little was known at that time about the physiological role played by the pituitary gland, and there was almost complete ignorance regarding the function of the hypothalamus. Acromegaly, or enlargement of acral body parts, described in 1886 by Pierre Marie, was the only disease linked to primary hypertrophies of the pituitary gland, known as “pituitary strumas”. A growing number of young patients manifesting an unexplained combination of physical and mental symptoms, including absent or delayed sexual maturation, progressive obesity, abnormal somnolence, and dementia-like changes in behavior were reported to present large solid-cystic tumors which characteristically expanded within the infundibulum and third ventricle, above an anatomically intact pituitary gland. Between 1899 and 1904, five seminal autopsy studies from different countries thoroughly described the anatomical relationships and histological features of this newly recognized type of infundibular tumors. These cases were instrumental in fostering the systematic investigation of similar lesions by the Austrian pathologist Jakob Erdheim (1874–1937), who in 1904 was able to classify these infundibulo-tuberal cysts under the common category of hypophyseal duct tumors. The pioneering American neurosurgeon Harvey Cushing (1869–1939) unsuccessfully attempted to surgically remove one of these cysts, for the first time in history, in 1902. The term “craniopharyngioma”, chosen by Cushing in 1929 to designate these lesions, would eventually prevail over Erdheim’s more accurate denomination, which linked their origin to squamous cell remnants derived from the embryological structures that give rise to the pituitary gland. This paper presents a comprehensive, renewed account of the five clinical-pathological reports which laid the groundwork for the proper clinical diagnosis, topographic conceptualization and pathological categorization of craniopharyngiomas.

Keywords

Craniopharyngioma Fröhlich’s syndrome Hypothalamus Infundibulum Jakob Erdheim Pituitary gland Rathke’s pouch Sir Frederick Mott 

Notes

Acknowledgements

The authors wish to thank Crystal Smith, Reference Librarian of the Department of History of Medicine at the National Library of Medicine, National Institutes of Health, Bethesda, Maryland, for her kind assistance during the process of searching and retrieving articles and monographs used in this study. The authors are also indebted to the staff at the Francis Countway Medical Library at Harvard Medical School, Boston, Massachusetts, for their invaluable help in obtaining some of the original research material used for this study. We would specially like to express our acknowledgement to the staff in the Narrenturm and the Jakob Erdheim Institute for their kind assistance and the original pictorial material provided for this study. Finally, the authors wish to express their gratitude to George Hamilton for his critical review of the language and style of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Erdheim J (1904) Über Hypophysengangsgeschwülste und Hirncholesteatome. Sitz Kais Akad Wissen Math Naturw Klin 113:537–726Google Scholar
  2. 2.
    Cushing H (1932) Notes upon a series of two thousand verified cases with surgical mortality percentages pertaining thereto. In: Intracranial tumors. Charles C Thomas, Springfield, IL, pp 93–98Google Scholar
  3. 3.
    Cushing H (1912) The pituitary body and its disorders: clinical states produced by disorders of the hypophysis cerebri. JB Lippincott, PhiladelphiaGoogle Scholar
  4. 4.
    Medvei VC (1982) A history of endocrinology. MTP Press Limited, Lancaster,CrossRefGoogle Scholar
  5. 5.
    Pascual JM, Prieto R, Mazzarello P (2015) Sir Victor Horsley: pioneer craniopharyngioma surgeon. J Neurosurg 123:39–51CrossRefPubMedGoogle Scholar
  6. 6.
    Pascual JM, Mongardi L, Prieto R, Castro-Dufourny I, Rosdolsky M, Strauss S, Carrasco R, Winter E, Mazzarello P (2017) Giovanni Verga (1879–1923), author of a pioneering treatise on pituitary surgery: the foundations of this new field in Europe in the early 1900s. Neurosurg Rev 40:559–575CrossRefPubMedGoogle Scholar
  7. 7.
    Pascual JM, Prieto R, Carrasco R, Castro-Dufourny I, Barrios L (2014) Development of intracranial approaches for craniopharyngiomas: an analysis of the first 160 historical procedures. Neurosurg Focus 36(4):E13CrossRefPubMedGoogle Scholar
  8. 8.
    Boyce R, Beadles CF (1893) A further contribution to the study of the pathology of the hypophysis cerebri. J Pathol Bacteriol 1:359–383CrossRefGoogle Scholar
  9. 9.
    Benda C (1900) Beiträge zur normalen und pathologischen Histologie der menschlichen hypophysis cerebri. Berl Klin Wochnschr 37:1205–1210Google Scholar
  10. 10.
    Onanoff J (1892) Sur un cas d´épithélioma (étude histologique). Thèse, Faculté de médecine, ParisGoogle Scholar
  11. 11.
    Babinski J (1900) Tumeur du corps pituitaire sans acromégalie et avec arrêt de développement des organes génitaux. Rev Neurol 8:531–533Google Scholar
  12. 12.
    Malassez LC (1885) Sur l’existence d’amas épithéliaux autor de la racine des dents chez l’homme adulte et à l’état normal (débris épithéliaux paradentaires). Arch Physiol Norm Pathol 5: 129–148Google Scholar
  13. 13.
    Critchley M, Ironside RN (1926) The pituitary adamantinomata. Brain 49:437–481CrossRefGoogle Scholar
  14. 14.
    Lopes MBS (2017) The 2017 World Health Organization classification of tumors of the pituitary gland: a summary. Acta Neuropathol 134:521–535CrossRefPubMedGoogle Scholar
  15. 15.
    Obituary (1926) Sir Frederick Mott, K.B.E., M.D., F.R.C.P., F.R.S., LL.D. Br Med J 1:1063–1065Google Scholar
  16. 16.
    Mott FW, Barratt JOW (1899) Three cases of tumor of the third ventricle. Arch Neurol (Lond) 1:417–439Google Scholar
  17. 17.
    Bostroem E (1897) Über piale Epidermoide, Dermoide und Lipome und durale Dermoide. Zentralbl Allg Pathol Path Anat 8:1–98Google Scholar
  18. 18.
    Beneke (1897) Zur Frage der meningealen Cholesteatome. Virchows Arch 149:95–123CrossRefGoogle Scholar
  19. 19.
    Pascual JM, Prieto R (2016) Harvery cushing and pituitary case number 3 (Mary D): the origin of this most baffling problem in neurosurgery. Neurosurg Focus 41:E6CrossRefPubMedGoogle Scholar
  20. 20.
    Fröhlich A (1901) Ein fall von tumor der hypophysis cerebri ohne akromegalie. Wien Klin Rundschau 15:883–886 906–908Google Scholar
  21. 21.
    Castro-Dufourny I, Carrasco R, Prieto R, Pascual JM (2015) Infundibulo-tuberal síndrome: the origins of clinical neuroendocrinology in France. Pituitary 18:838–843CrossRefPubMedGoogle Scholar
  22. 22.
    Eiselsberg FV, Frankl-Hochwart LV (1907) Über operative behandlung der tumoren der hypophysengegend. Neurol Centralb 26:994–1001Google Scholar
  23. 23.
    Eiselsberg FV (1910) Operations upon the hypophysis. Ann Surg 52: 1–14CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Eiselsberg A (1923) Über den Endausgang und die Obduktion meines ersten operierten Falles von Hypophysistumor. Beitr Pathol Anat 71:619–626Google Scholar
  25. 25.
    Cushing H (1906) Sexual infantilism with optic atrophy in cases of tumors affecting the hypophysis cerebral. J Nerv Ment Dis 33:704–716CrossRefGoogle Scholar
  26. 26.
    Cushing H (1909) The hypophysis cerebri: clinical aspects of hyperpituitarism and of hypopituitarism. JAMA 53:249–255CrossRefGoogle Scholar
  27. 27.
    Pascual JM, Rosdolsky M, Prieto R, Strauβ S, Winter E, Ulrich W (2015) Jakob Erdheim (1874–1937): father of hypophyseal-duct tumors (craniopharyngiomas). Virchows Arch 467:459–469CrossRefPubMedGoogle Scholar
  28. 28.
    Berger A (1904) Ein Fall von Tumor der Hypophysengegend mit Obductionsbefund. Zeitschr Klin Med 54:448–464Google Scholar
  29. 29.
    Cho KH, Chang H, Yamamoto HA, Rodriguez-Vazquez JF, Murakami G, Katori Y (2013) Rathke’s pouch remnant and its regression process in the prenatal period. Childs Nerv Syst 29:761–769CrossRefPubMedGoogle Scholar
  30. 30.
    Bernstein ML, Buchino JJ (1983) The histologic similarity between craniopharyngioma and odontogenic lesions: a reappraisal. Oral Surg Oral Med Pathol 56:502–511CrossRefGoogle Scholar
  31. 31.
    Luschka HV (1860) Der Hirnanhang und die Steissdrüse des Menschen. Verlag Von Georg Reimer, BerlinGoogle Scholar
  32. 32.
    Pascual JM, Prieto R, Carrasco R (2011) Infundibulo-tuberal or not strictly intraventricular craniopharyngioma: evidence for a major topographical category. Acta Neurochir (Wien) 153:2403–2426CrossRefGoogle Scholar
  33. 33.
    Castro-Dufourny I, Carrasco R, Prieto R, Pascual JM (2017) Jean Camus and Gustave Roussy: pioneering French researchers on the endocrine functions of the hypothalamus. Pituitary 20:409–421CrossRefPubMedGoogle Scholar
  34. 34.
    Bailey P, Bremer F (1921) Experimental diabetes insipidus. Arch Int Med 28:773–803CrossRefGoogle Scholar
  35. 35.
    Fulton JF, Bailey P (1929) Contribution to the study of tumors in the region of the third ventricle: their diagnosis and relation to pathological sleep. J Nerv Ment Dis 69:1–277CrossRefGoogle Scholar
  36. 36.
    Cushing H (1932) Papers relating to the pituitary body, hypothalamus and parasympathetic nervous system. Charles C. Thomas, Springfield, IL, pp 43–56Google Scholar
  37. 37.
    Cushing H (1913) Psychic disturbances associated with disorders of the ductless glands. Am J Insanity 69:965–990Google Scholar
  38. 38.
    Reeves AG, Plum F (1969) Hyperphagia, rage and dementia accompanying a ventromedial hypothalamic neoplasm. Arch Neurol 20:616–624CrossRefPubMedGoogle Scholar
  39. 39.
    Williams M, Pennybacker J (1954) Memory disturbances in third ventricle tumours. J Neurol Neurosurg Psychiatr 17:115–123CrossRefGoogle Scholar
  40. 40.
    Castro-Dufourny I, Carrasco R, Prieto R, Barrios L, Pascual JM (2015) The infundibulo-tuberal syndrome caused by craniopharyngiomas: clinicopathological evidence from an historical French cohort (1705–1973). Pituitary 18:642–657CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • José M. Pascual
    • 1
  • Ruth Prieto
    • 2
  • Maria Rosdolsky
    • 3
  • Sewan Strauss
    • 4
  • Inés Castro-Dufourny
    • 5
  • Verena Hofecker
    • 6
  • Eduard Winter
    • 6
  • Rodrigo Carrasco
    • 7
  • Walter Ulrich
    • 8
  1. 1.Department of NeurosurgeryLa Princesa University HospitalMadridSpain
  2. 2.Department of NeurosurgeryPuerta de Hierro University HospitalMadridSpain
  3. 3.Independent Medical TranslatorJenkintownUSA
  4. 4.Department of PediatricsHospital Dahme-SpreewaldKönigs WusterhausenGermany
  5. 5.Department of EndocrinologySureste University HospitalMadridSpain
  6. 6.Pathologisch-anatomische Sammlung im Narrenturm-NHMViennaAustria
  7. 7.Department of NeurosurgeryRamón y Cajal University HospitalMadridSpain
  8. 8.Department of Pathology and Clinical BacteriologyJakob Erdheim InstituteViennaAustria

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