Pituitary

, Volume 20, Issue 3, pp 349–357 | Cite as

Two-dimensional speckle tracking echocardiography demonstrates no effect of active acromegaly on left ventricular strain

  • I. C. M. Volschan
  • L. Kasuki
  • C. M. S. Silva
  • M. L. Alcantara
  • R. M. Saraiva
  • S. S. Xavier
  • M. R. Gadelha
Article

Abstract

Background

Speckle tracking echocardiography (STE) allows for the study of myocardial strain (ε), a marker of early and subclinical ventricular systolic dysfunction. Cardiac disease may be present in patients with acromegaly; however, STE has never been used to evaluate these patients.

Objective

To evaluate left ventricular (LV) global longitudinal strain in patients with active acromegaly with normal LV systolic function.

Design

Cross-sectional clinical study.

Methods

Patients with active acromegaly with no detectable heart disease and a control group were matched for age, gender, arterial hypertension and diabetes mellitus underwent STE. Global LV longitudinal ε (GLS), left ventricular mass index (LVMi), left ventricular ejection fraction (LVEF) and relative wall thickness (RWT) were obtained via two-dimensional (2D) echocardiography using STE.

Results

Thirty-seven patients with active acromegaly (mean age 45.6 ± 13.8; 48.6% were males) and 48 controls were included. The mean GLS was not significantly different between the acromegaly group and the control group (in %, −20.1 ± 3.1 vs. −19.4 ± 2.2, p = 0.256). Mean LVMi was increased in the acromegaly group (in g/m2, 101.6 ± 27.1 vs. 73.2 ± 18.6, p < 0.01). There was a negative correlation between LVMi and GLS (r = −0.39, p = 0.01).

Conclusions

Acromegaly patients, despite presenting with a higher LVMi when analyzed by 2D echocardiography, did not present with impairment in the strain when compared to a control group; this finding indicates a low chance of evolution to systolic dysfunction and agrees with recent studies that show a lower frequency of cardiac disease in these patients.

Keywords

Acromegaly Left ventricular strain Speckle tracking echocardiography Cardiopathy 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • I. C. M. Volschan
    • 1
  • L. Kasuki
    • 2
    • 3
    • 4
  • C. M. S. Silva
    • 2
  • M. L. Alcantara
    • 5
  • R. M. Saraiva
    • 6
  • S. S. Xavier
    • 1
  • M. R. Gadelha
    • 2
    • 3
  1. 1.Cardiology Section, Medical School and Hospital Universitário Clementino Fraga FilhoUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil
  2. 2.Neuroendocrinology Research Center/ Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga FilhoUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil
  3. 3.Neuroendocrine Unit, Instituto Estadual do Cérebro Paulo NiemeyerSecretaria Estadual de Saúde do Rio de JaneiroRio de JaneiroBrazil
  4. 4.Endocrine SectionHospital Federal de BonsucessoRio de JaneiroBrazil
  5. 5.Echocardiographic SectionHospital Samaritano e Americas Medical CityRio de JaneiroBrazil
  6. 6.Instituto Nacional de Infectologia Evandro ChagasFundação Oswaldo CruzRio de JaneiroBrazil

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