, Volume 20, Issue 3, pp 393–394 | Cite as

Chordoid glioma: A new paradigm of hypothalamic dysfunction?

  • Inés Castro-DufournyEmail author
  • Rodrigo Carrasco
  • José M. Pascual

To the Editor,

We have read with great interest the article recently published by Calanchini et al. in Pituitary (2016; 19: 356–361), dealing with an extraordinary association between SIADH and a chordoid glioma (CG) of the third ventricle. As the authors state, CG represents a rare neoplasm supposedly arising in the organum vasculosum of the lamina terminalis that slowly grows into the anterior-inferior portion of the third ventricular chamber, distorting its walls. Definitive conclusions concerning its clinical profile, radiological characteristics and therapeutic management are lacking, since most information available in the scientific literature comes from only a few case reports. Nevertheless, it is our opinion that the clinician facing such a challenging tumor may benefit from available theoretical models based on the study of other types of more frequent tumors displaying this topography [1].

From a pathophysiological standpoint, CGs should cause similar effects to those of...


Diabetes Insipida Craniopharyngiomas Lamina Terminalis Mamillary Body Intraventricular Tumor 
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Compliance with ethical standards

Conflict of interest

Inés Castro-Dufourny declares that she has no conflict of interest. Rodrigo Carrasco declares that he has no conflict of interest. José María Pascual declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


  1. 1.
    Castro-Dufourny I, Carrasco R, Prieto R, Barrios L, Pascual JM (2015) The infundibulo-tuberal syndrome caused by craniopharyngiomas. Clinicopathological evidence from an historical French cohort (1705–1973). Pituitary 18:642–657CrossRefPubMedGoogle Scholar
  2. 2.
    McKinley MJ, Mathai ML, McAllen RM, McClear RC, Miselis RR, Pennington GL, Vivast L, Wade JD, Oldfield BJ (2004) Vasopressin secretion: osmotic and hormonal regulation by the lamina terminalis. J Neuroendocrinol 16:340–347CrossRefPubMedGoogle Scholar
  3. 3.
    Pascual JM, Prieto R, Carrasco R, Barrios L (2013) Displacement of mammillary bodies by craniopharyngiomas involving the third ventricle: surgical-MRI correlations and use in topographical diagnosis. J Neurosurg 119:381–405CrossRefPubMedGoogle Scholar
  4. 4.
    Carrasco R, Pascual JM, Reina T, Nieto S, Linera J, Sola RG (2008) Chordoid glioma of the third ventricle attached to the optic chiasm. Successful removal through a trans-lamina terminalis approach. Clin Neurol Neurosurg 110:828–833CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Inés Castro-Dufourny
    • 1
    Email author
  • Rodrigo Carrasco
    • 2
  • José M. Pascual
    • 3
  1. 1.Department of EndocrinologySureste University HospitalArganda del ReySpain
  2. 2.Ramón y Cajal University HospitalMadridSpain
  3. 3.La Princesa University HospitalMadridSpain

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