Pituitary

, Volume 18, Issue 2, pp 201–205 | Cite as

Screening for Cushing’s syndrome: Is it worthwhile?

Article

Abstract

Introduction

Cushing’s syndrome (CS) is a rare disease characterized by a collection of signs and symptoms, also common in the general population without elevated cortisol secretion. During the last years more patients with CS are identified earlier and with milder disease. Many of these patients are diagnosed during screening efforts performed for certain or isolated complaints like weight gain, diabetes mellitus (DM), hypertension, osteoporosis, elevated white blood cell counts and more.

Methods

In this review article the most popular screening test performed in the studies cited was the 1-mg dexamethasone suppression test.

Conclusions

Cushing is not frequent enough to support the use of routine screening in patients with morbid obesity and type 2 DM. Also only 1 % of hypertensive patients have secondary hypertension due to CS. However, screening should be considered in young patients with resistant DM and/or hypertension. Among patients with osteoporosis and vertebral fractures up to 5 % were diagnosed with subclinical hypercortisolism; most of these had adrenal adenoma. Screening for CS is important in subjects with adrenal incidentaloma, and many studies show a high prevalence (~10 %) of Cushing or subclinical CS in these patients.

Keywords

Adrenal Cortisol Cushing’s syndrome Dexamethasone suppression test Screening 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Rabin Medical Center, Institute of Endocrinology and MetabolismBeilinson HospitalPetach TikvaIsrael
  2. 2.Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

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