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Pituitary

, Volume 12, Issue 1, pp 15–22 | Cite as

Radiotherapy of nonfunctioning and gonadotroph adenomas

  • Andrew A. Kanner
  • Benjamin W. Corn
  • Yona GreenmanEmail author
Article

Abstract

Transsphenoidal surgery is the treatment of choice for NFPA but is seldom curative. The management of patients in whom residual tumor is detected after surgery is not clear-cut. Radiation therapy is effective in controlling tumor mass in the majority of patients, but is associated with long term complications that call for restriction of its use to patients at high risk for tumor growth. New radiation techniques may prove to be safer while retaining the effectiveness of conventional radiotherapy, however longer follow-up is necessary to confirm this assumption. For now, it appears to be safe to withhold radiation and carefully follow patients with small tumor remnants, whereas large remnants from invasive tumors should be considered for radiotherapy. Nevertheless, there are no prospective controlled studies that support this empirical approach.

Keywords

Pituitary adenoma Non-secreting Conventional radiotherapy Conformal radiotherapy Stereotactic radiosurgery 

Notes

Acknowledgment

The authors want to thank Prof. Deborah T. Blumenthal M.D. for the critical review of the manuscript.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Andrew A. Kanner
    • 1
  • Benjamin W. Corn
    • 2
  • Yona Greenman
    • 3
    Email author
  1. 1.Stereotactic Radiosurgery Unit, Department of Neurosurgery, Tel Aviv-Sourasky Medical Center, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  2. 2.Institute of Radiotherapy, Tel Aviv-Sourasky Medical Center, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

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