, Volume 10, Issue 1, pp 107–111 | Cite as

Fatal inflammatory hypophysitis

  • Elizabeth A. McIntyre
  • Petros PerrosEmail author
Case Report


A young female patient presented as an acute medical emergency with hypoglycaemia. Investigations revealed panhypopituitarism and an inflammatory pituitary mass. An antibody screen was negative for anti-neutrophil cytoplasmic antibodies with cytoplasmic distribution (cANCA). Pituitary histology showed lymphocytic infiltration and a few Langerhan’s cells. The pituitary mass rapidly expanded to involve the optic nerves and led to bilateral blindness. Later, the patient developed diarrhoea, a vasculitis rash, scleritis, and proteinuria. In subsequent investigations cANCA became positive. The patient responded to steroids and cyclophosphamide treatment and remained in partial remission for six months before dying of severe sepsis. This is the first description of Wegener’s granulomatosis presenting with acute anterior pituitary failure in the absence of other organ involvement and negative serology.


Pituitary mass Wegener’s granulomatosis Hypophysitis 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Endocrine UnitNewcastle Hospitals NHS Trust, Freeman HospitalNewcastle upon TyneUK

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