, Volume 10, Issue 1, pp 87–93 | Cite as

Transient gestational diabetes insipidus diagnosed in successive pregnancies: review of pathophysiology, diagnosis, treatment, and management of delivery

  • Ibrahim Kalelioglu
  • Ayse Kubat Uzum
  • Alkan Yildirim
  • Tulay Ozkan
  • Funda Gungor
  • Recep Has
Case Report


Gestational diabetes insipidus (GDI) is a rare disorder characterised by polyuria, polydypsia, and excessive thirst usually manifesting in the third trimester of pregnancy. The etiology is thought to depend on excessive vasopressinase activity, a placental enzyme that degrades arginine-vasopressin (AVP), but not 1-deamino-8-d-arginine vasopressin (dDAVP), which is a synthetic form. This is a transient syndrome and may be associated with acute fatty liver of pregnancy and preeclampsia. The use of dDAVP in symptomatic cases has been proven as a safe method for both the mother and the fetus during the pregnancy. We report a case of recurrent gestational diabetes insipidus in successive pregnancies, which responded to dDAVP and subsided after delivery.


Diabetes insipidus Desmopressin Vasopressin Pregnancy 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Ibrahim Kalelioglu
    • 1
  • Ayse Kubat Uzum
    • 2
    • 4
  • Alkan Yildirim
    • 1
  • Tulay Ozkan
    • 3
  • Funda Gungor
    • 1
  • Recep Has
    • 1
  1. 1.Istanbul Faculty of Medicine, Gynecology and ObstetricsIstanbul UniversityIstanbulTurkey
  2. 2.Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and MetabolismIstanbul UniversityIstanbulTurkey
  3. 3.Istanbul Faculty of Medicine, Department of AnesthesiaIstanbul UniversityIstanbulTurkey
  4. 4.Prof. Dr. Turan Gunes Cad. Bau San Veliefendi EvleriZeytinburnu/IstanbulTurkey

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