Pituitary

, Volume 8, Issue 3–4, pp 263–266 | Cite as

Traumatic Brain Injury Induced Hypopituitarism: The Need and Hope of Rehabilitation

Article

Abstract

Traumatic brain injury is a leading cause of death and disability in developed countries. Damage caused by focal and diffuse lesions produces symptoms involving most major medical systems as well as symptoms of neurological and psychological origin. The severity of a traumatic brain injury is difficult to assess, and therefore, an initial accurate prognosis is difficult as well. Present treatments focus on relieving symptoms without adequately addressing the underlying cause of those symptoms. Recent studies have shown anterior pituitary deficiencies to be common amongst survivors of TBI. As many symptoms ascribed to a TBI are similar to the symptoms of hypopituitarism, it is possible that treatment of these deficiencies will improve functioning and the quality of life for survivors of traumatic brain injuries.

Key Words

traumatic brain injury rehabilitation hypopituitarism 

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References

  1. 1.
    Rehabilitation of Persons with Traumatic Brain Injury. NIH Consensus Statement 1998;16(1):1–41.Google Scholar
  2. 2.
    Cope DN. The Rehabilitation of Traumatic Brain Injury. In Kottke FJ, Lehmann JF, eds. Krusen's Handbook of Physical Medicine and Rehabilitation. Philadelphia: W.B. Saunders, 1990:1217–1241.Google Scholar
  3. 3.
    Troncoso JC, Gordon B. Neuropathology of Closed Head Injury. In Rizzo M, Tranel D, eds. Head Injury and Postconcussive Syndrome. Edinburgh, UK: Churchill Livingstone, 1996:47–56.Google Scholar
  4. 4.
    Sandel ME, Bell KR, Michaud LJ. Brain injury rehabilitation. 1. Traumatic brain injury: prevention, pathophysiology, and outcome prediction. Arch Phys Med Rehabil 1998;82:S3–S9.Google Scholar
  5. 5.
    Kalisky Z, Morrison DP, Meyers CA, et al. Medical problems encountered during rehabilitation of patients with head injury. Arch Phys Med Rehabil 1985;66:25–29.PubMedGoogle Scholar
  6. 6.
    Consensus Conference, Prevention of venous thrombosis and pulmonary embolism. JAMA 1986;256:744–749.Google Scholar
  7. 7.
    Garland DE, Gailey, S, Rhoades ME. Orthopedic management of brain injured adults. Part II, Clin Orthop Rel Res 1978;131:111–122.Google Scholar
  8. 8.
    Eldresi MS, Urban RJ, Lieberman SA. Brain injury and neuroendocrine function. Endocrinologist 2001;11:275–281.Google Scholar
  9. 9.
    Bondanelli M, De Marinis L, Ambrosio MR, Monesi M. Occurrence of pituitary dysfunction following traumatic brain injury. J Neurotrauma 2004;21:685–696.CrossRefPubMedGoogle Scholar
  10. 10.
    Lieberman SA, Oberoi AL, Gilkison CR, et al. Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury. J Clin Endocrinol Metab 2001;86:2752–2756.CrossRefPubMedGoogle Scholar
  11. 11.
    Kelly DF, Gonzalo IT, Cohan P et al. Hypopituitarism following traumatic brain injury and aneurysmal subarachnoid hemorrhage: A preliminary report. J Neurosurg 2000;93:743–752.PubMedGoogle Scholar
  12. 12.
    Agha A, Rogers B, Sherlock M, et al. Anterior pituitary dysfunction in survivors of traumatic brain injury. J Clin Endocrinol Metab 2004;89:4929–4936.PubMedGoogle Scholar
  13. 13.
    Aimaretti G, Ambrosio MR, Di Somma C, et al. Traumatic brain injury and subarachnoid hemorrhage are conditions at high risk for hypopituitarism screening study at 3 months after the brain injury. Clinical Endocrinology 2004;61:320–326.CrossRefPubMedGoogle Scholar
  14. 14.
    Hellawell DJ, Taylor R, Pentland B. Cognitive and psychosocial outcome following moderate or severe traumatic brain injury. Brain Injury 1999:489–504.Google Scholar
  15. 15.
    Masel BE, Scheibel RS, Kimbark T, Kuna ST. Excessive daytime sleepiness in adults with brain injuries. Arch Phys Med Rehabil 2001;82:1526–1532.CrossRefPubMedGoogle Scholar
  16. 16.
    Thomsen IV. Late outcome of very severe blunt head trauma. A 10–15 year second follow-up. J Neurol Neurosurg Psychiatry 1984;46:870–875.Google Scholar
  17. 17.
    Torner JC, Shootman M. Epidemiology of Closed Head Injury. In Rizzo M, Tranel D, eds. Head Injury and Postconcussive Syndrome. Edinburgh, UK: Churchill Livingstone, 1996:19–46.Google Scholar
  18. 18.
    Katz DI, Alexander MP. Traumatic brain injury: Predicting the course of recovery and outcome for patients admitted to rehabilitation. Arch Neurol 1994;51:661–670.PubMedGoogle Scholar
  19. 19.
    Jameson LJ. Principals of Endocrinology. In Kasper DL, Braunwald E, Fauci AS, eds. Harrison's Principals of Internal Medicine, 16th ed. New York: McGraw Hill 2005;2067–2104.Google Scholar
  20. 20.
    Wang C, Alexander G, Berman N. Testosterone replacement therapy improves mood in hypogonadal men: A clinical research center study. J Clin Endocrinol Metab 1995;81:3578–3583.Google Scholar
  21. 21.
    Barrett-Conner E, Stuenkel CA. Hormone replacement therapy: Risks and benefits. Int J Epidemiol 2001;30:423–426.Google Scholar
  22. 22.
    Gibney J, Wallace D, Spinks T, et al. The effects of 10 years of recombinant human growth hormone in adult GH deficient patients. J Clin Endocrinol Metab1999;84:2596–2602.CrossRefPubMedGoogle Scholar
  23. 23.
    Burman P, Broman JE, Hetta J, et al. Quality of life in adults with growth hormone deficiency: Response to treatment with recombinant human GH in a placebo-controlled 21-month trial. J Clin Endocrinol Metab 1995:80:3585–3390.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  1. 1.Transitional Learning Center at GalvestonGalveston
  2. 2.Transitional Learning Center at GalvestonGalveston

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