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Phytochemistry Reviews

, Volume 18, Issue 4, pp 1025–1049 | Cite as

Citrus fruits and inflammaging: a systematic review

  • Alessandro Maugeri
  • Santa Cirmi
  • Paola Lucia Minciullo
  • Sebastiano Gangemi
  • Gioacchino Calapai
  • Vincenzo Mollace
  • Michele NavarraEmail author
Article

Abstract

Inflammaging is a low-grade, chronic, asymptomatic, controlled and systemic pro-inflammatory status that appears during the aging process and is linked to many age-related diseases. Growing evidence indicates that Mediterranean diet is a reliable instrument to counteract inflammaging, due to its high content of flavonoids, whose main source are Citrus fruits. Our objective was to summarize and critically discuss the rich clinical evidence on the properties of Citrus fruits and their derivatives focusing on a series of age-related diseases and their potential use to maintain health in aging populations. A systematic review of articles using MEDLINE, Web of Sciences and Scopus was performed independently by two reviewers. Search terms included keywords related to Citrus fruits or their derivatives and inflammation. No language restriction was applied. The last search was performed on November 15th, 2018. The study selection and systematic review were carried out in accordance with the PRISMA statement. Prior to the beginning of the review, Authors defined a checklist for inclusion criteria. Three reviewers independently performed the extraction of articles. Eighty-five papers met our inclusion criteria and were eligible for inclusion in the final review.  Citrus fruits seem to possess capabilities in counteracting inflammation-based age-related diseases, thus representing a possible weapon to fight inflammaging. This review may be used as a scientific basis for further studies on the role of Citrus fruits consumption and inflammaging.

Keywords

Aging Anti-inflammatory Inflammation Orange Bergamot 

Abbreviations

AML

Amyotrophic lateral sclerosis

AUC

Area under curve

BJ

Bergamot juice

BJe

Bergamot juice extract

BMI

Body mass index

CI

Confidence interval

Cmax

Maximum plasma concentration

HPJ

High polyphenol concentration orange juice

HPV-16

Human papillomavirus 16

HR

Hazard ratio

IBD

Inflammatory bowel disease

LUTS

Lower urinary tract symptoms

MetS

Metabolic syndrome

NPJ

Normal polyphenol concentration orange juice

OR

Odds ratio

PAI-1

Plasminogen activator inhibitor-1 activity

PRISMA

Preferred reporting items for systematic reviews and meta-analyses

RR

Risk ratio

ROS

Reactive oxygen species

Tmax

Time to reach the maximum plasma concentration

Notes

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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Chemical, Biological, Pharmaceutical and Environmental SciencesUniversity of MessinaMessinaItaly
  2. 2.Department of Clinical and Experimental MedicineUniversity of MessinaMessinaItaly
  3. 3.Department of Biomedical and Dental Sciences and Morphofunctional ImagingUniversity of MessinaMessinaItaly
  4. 4.Department of Health SciencesUniversity “Magna Graecia” of CatanzaroCatanzaroItaly

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