Natural and hemi-synthetic pentacyclic triterpenes as antimicrobials and resistance modifying agents against Staphylococcus aureus: a review

  • Lucy Catteau
  • Li Zhu
  • Françoise Van Bambeke
  • Joëlle Quetin-Leclercq
Article
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Abstract

Staphylococcus aureus infections are considered as seriously problematic for human health and necessitate the development of new medicines and innovative antimicrobial strategies. Plant secondary metabolites have already demonstrated their potential as antibacterials when used alone but also in combination with other antimicrobial agents to potentiate their activity. Triterpenoids are widely distributed in the plant kingdom and known to have many beneficial effects, including anti-inflammatory, immunomodulatory, anti-proliferative, antimycotic, or antimicrobial activity. The aim of this paper is to review the activity of pentacyclic triterpenoids belonging to the ursane, oleanane, or lupane groups against Staphylococcus aureus. We summarize their activity as anti-staphylococcal compounds but also as resistance modifying agents when combined with common antibiotics.

Keywords

Ursane Oleanane Lupane MIC FICI Staphylococcus aureus 

Abbreviations

ATCC

American type culture collection

BA

betulinic acid

CA

ceanothic acid

FICI

fractional inhibitory concentration index

MA

maslinic acid

MIC

minimum inhibitory concentration

MSSA

methicillin-sensitive Staphylococcus aureus

MRSA

methicillin-resistant Staphylococcus aureus

MTCC

microbial type culture collection

NBRC

NITE (National Institute of Technology and Evaluation) Biological Resource Center

OA

oleanolic acid

PBP

penicillin binding protein

SAR

structure activity-relationship

UA

ursolic acid

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Supplementary material

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Supplementary material 1 (DOCX 360 kb)

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© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Pharmacognosy Research Group, Louvain Drug Research InstituteUniversité catholique de LouvainBrusselsBelgium
  2. 2.Pharmacologie cellulaire et moléculaire, Louvain Drug Research InstituteUniversité catholique de LouvainBrusselsBelgium

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