Skip to main content

Advertisement

SpringerLink
Log in

Phenolic compounds in fruits and beverages consumed as part of the mediterranean diet: their role in prevention of chronic diseases

  • Published:
Phytochemistry Reviews Aims and scope Submit manuscript

Abstract

The objective of this review was to assess, based on human data, the role of phenolic compounds in selected plant foods consumed as part of the Mediterranean diet in the prevention of chronic diseases (CDs) like cardiovascular disease, cancer and neurodegenerative conditions. Fruits and vegetables are rich sources of phenolic compounds and based on scientific data it would be expected that their consumption, as part of the diet, would be responsible for their documented preventive role of chronic diseases. The results of the review of scientific literature on human clinical trials revealed that in some studies polyphenols exert a positive effect in the prevention of cardiovascular disease, essentially blood pressure and arterial dilation, certain types of cancer and neurodegenerative disorders. However, such effects are not consistent with other clinical studies in which no effect has been found. Therefore, the level of evidence for a beneficial effect in humans of phenols on the prevention of CDs is weak and need to be strengthened by additional studies addressing potential confounding factors, such as interaction of phenols with other bioactive substances in foods and potential pro-oxidant effects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

Abbreviations

5-CQA:

5-Caffeoylquinic acid

ACN:

Anthocyanins

BOLD:

Blood oxygenation level-dependent

BP:

Blood pressure

BT:

Black tea

CAD:

Coronary artery disease

CF:

Cocoa flavan-3-ols

CHD:

Coronary heart disease

CVDs:

Cardiovascular Diseases

EF:

Endothelial function

EGCG:

Epigallocatechin-3-O-gallate

EPIC:

European Prospective Investigation into Cancer and Nutrition

EUFIC:

European Food Information Council

FMD:

Flow-mediated dilation

GT:

Green tea

GTCs:

Green tea catechins

HF:

High flavanols

IF:

Intermediate flavanols

IGT:

Impaired glucose tolerance

MED:

Minimal erythema dose

MS:

Metabolic syndrome

NCDs:

Noncommunicable diseases

nd:

Not detected

OPL:

Oral premalignant lesions

Pro:

Procyanidins

RCTs:

Randomized controlled trial

TP:

Total polyphenols

References

  • Alasalvara C, Bollinga BW (2015) Review of nut phytochemicals, fat-soluble bioactives, antioxidant components and health effects. Br J Nutr 113(S2):68–78

    Article  CAS  Google Scholar 

  • Baba S, Natsume M, Yasuda A et al (2007) Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder. J Nutr 137:1436–1441

    CAS  PubMed  Google Scholar 

  • Baena Ruiz R, Salinas Hernández P (2014) Diet and cancer: risk factors and epidemiological evidence. Maturitas 77(3):202–208

    Article  CAS  PubMed  Google Scholar 

  • Barona J, Aristizabal JC, Blesso CN et al (2012) Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr 142(9):1626–1632

    Article  CAS  PubMed  Google Scholar 

  • Basu A, Du M, Leyva MJ et al (2010a) Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 140(9):1582–1587

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Basu A, Sanchez K, Leyva MJ et al (2010b) Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome. J Am Coll Nutr 29:31–40

    Article  CAS  PubMed  Google Scholar 

  • Bettuzzi S, Brausi M, Rizzi F et al (2006) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 66(2):1234–1240

    Article  CAS  PubMed  Google Scholar 

  • Bogdanski P, Suliburska J, Szulinska M et al (2012) Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res 32(6):421–427

    Article  CAS  PubMed  Google Scholar 

  • Botden IPG, Draijer R, Westerhof BE et al (2012) Red wine polyphenols do not lower peripheral or central blood pressure in high normal blood pressure and hypertension. Am J Hypertens 25(6):718–723

    Article  CAS  PubMed  Google Scholar 

  • Brown AL, Lane J, Holyoak C et al (2011) Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial. Br J Nutr 106(12):1880–1889

    Article  CAS  PubMed  Google Scholar 

  • Brown EM, Latimer C, Allsopp P et al (2014) In vitro and in vivo models of colorectal cancer: antigenotoxic activity of berries. J Agric Food Chem 62(18):3852–3866

    Article  CAS  PubMed  Google Scholar 

  • Bulló M, Juanola-Falgarona M, Hernández-Alonso P, Salas-Salvadó J (2015) Nutrition attributes and health effects of pistachio nuts. Br J Nutr 113(S2):79–93

    Article  CAS  Google Scholar 

  • Buscemi S, Verga S, Batsis JA et al (2009) Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects. Eur J Clin Nutr 63(10):1200–1205

    Article  CAS  PubMed  Google Scholar 

  • Buscemi S, Verga S, Batsis JA et al (2010) Acute effects of coffee on endothelial function in healthy subjects. Eur J Clin Nutr 64(5):483–489

    Article  CAS  PubMed  Google Scholar 

  • Cai L, Ma D, Zhang Y et al (2012) The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials. Eur J Clin Nutr 66(8):872–877

    Article  CAS  PubMed  Google Scholar 

  • Camfield DA, Scholey A, Pipingas A et al (2012) Steady state visually evoked potential (SSVEP) topography changes associated with cocoa flavanol consumption. Physiol Behav 105:948–957

    Article  CAS  PubMed  Google Scholar 

  • Careri M, Elviri L, Mangia A et al (2000) Spectrophotometric and coulometric detection in the high-performance liquid chromatography of flavonoids and optimization of sample treatment for the determination of quercetin in orange juice. J Chromatogr A 881:449–460

  • Carter P, Gray LJ, Troughton J et al (2010) Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis. BMJ 341(7772):543

    Google Scholar 

  • Ceci LN, Carelli AA (2007) Characterization of monovarietal Argentinian olive oils from new productive zones. J Am Oil Chem Soc 84(12):1125–1136

    Article  CAS  Google Scholar 

  • Chen Y, Tsai AC, Wang J (2013) The combined effect of physical activity and fruit-vegetable consumption on new-onset diabetes in older Taiwanese. Taiwan J Pub Health 32(6):551–561

    Google Scholar 

  • Chiva-Blanch G, Urpi-Sarda M, Ros E et al (2012) Dealcoholized red wine decreases systolic and diastolic blood pressure and increases plasma nitric oxide: short communication. Circ Res 111(8):1065–1068

    Article  CAS  PubMed  Google Scholar 

  • Chiva-Blanch G, Urpi-Sarda M, Ros E et al (2013) Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: a randomized clinical trial. Clin Nutr 32(2):200–206

    Article  CAS  PubMed  Google Scholar 

  • Crews WD Jr, Harrison DW, Wright JW (2008) A double-blind, placebo-controlled, randomized trial of the effects of dark chocolate and cocoa on variables associated with neuropsychological functioning and cardiovascular health: clinical findings from a sample of healthy, cognitively intact older adults. Am J Clin Nutr 87(4):872–880

    CAS  PubMed  Google Scholar 

  • Davis DR (2009) Declining fruit and vegetable nutrient composition: what is the evidence? HortScience 44(1):15–19

    Google Scholar 

  • De Bock M, Derraik JGB, Brennan CM et al (2013) Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PLoS ONE 8(3). doi:10.1371/journal.pone.0057622

  • Del Bo’ C, Riso P, Campolo J et al (2013) A single portion of blueberry (Vaccinium corymbosum L.) improves protection against DNA damage but not vascular function in healthy male volunteers. Nutr Res 33(3):220–227

    Article  CAS  Google Scholar 

  • Desch S, Schmidt J, Kobler D et al (2010) Effect of cocoa products on blood pressure: systematic review and meta-analysis. Am J Hypertens 23(1):97–103

    Article  CAS  PubMed  Google Scholar 

  • Desideri G, Kwik-Uribe C, Grassi D et al (2012) Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the cocoa, cognition, and aging (CoCoA) study. Hypertension 60(3):794–801

    Article  CAS  PubMed  Google Scholar 

  • Devore EE, Kang JH, Breteler MMB et al (2012) Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol 72(1):135–143

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dohadwala MM, Holbrook M, Hamburg NM, Shenouda SM, Chung WB, Titas M, Kluge MA, Wang N, Palmisano J, Milbury PE, Blumberg JB, Vita JA (2011) Effects of cranberry juice consumption on vascular function in patients with coronary artery disease. Am J Clin Nutr 93:934–940

  • Duthie SJ, Jenkinson AM, Crozier A et al (2006) The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. Eur J Nutr 45(2):113–122

    Article  CAS  PubMed  Google Scholar 

  • Erlund I, Koli R, Alfthan G et al (2008) Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 87(2):323–331

    CAS  PubMed  Google Scholar 

  • European Food Information Council (EUFIC) UE, http://www.eufic.org/index/es/, Feb 2015

  • Faridi Z, Njike VY, Dutta S et al (2008) Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial. Am J Clin Nutr 88(1):58–63

    CAS  PubMed  Google Scholar 

  • Flammer AJ, Sudano I, Wolfrum M et al (2012) Cardiovascular effects of flavanol-rich chocolate in patients with heart failure. Eur Heart J 33(17):2172–2180

    Article  CAS  PubMed  Google Scholar 

  • Francis ST, Head K, Morris PG et al (2006) The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people. J Cardiovasc Pharmacol 47:S215–S220

    Article  CAS  PubMed  Google Scholar 

  • Fujioka K, Shibamoto T (2006) Quantitation of volatiles and nonvolatile acids in an extract from coffee beverages: correlation with antioxidant activity. J Agric Food Chem 54(16):6054–6058

    Article  CAS  PubMed  Google Scholar 

  • Gardner PT, White TAC, McPhail DB et al (2000) The relative contributions of vitamin C, carotenoids and phenolics to the antioxidant potential of fruit juices. Food Chem 68(4):471–474

    Article  CAS  Google Scholar 

  • Gilbert-López B, Valencia-Reyes ZL, Yufra-Picardo VM et al (2014) Determination of polyphenols in commercial extra virgin olive oils from different origins (Mediterranean and South American countries) by liquid chromatography–electrospray time-of-flight mass spectrometry. Food Anal Meth 7(9):1824–1833

    Article  Google Scholar 

  • Giovannelli L, Pitozzi V, Luceri C et al (2011) Effects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women. Eur J Nutr 50(1):19–29

    Article  CAS  PubMed  Google Scholar 

  • Gonzalez de Mejia E, Johnson MH (2014) Anthocyanins from berries: chemistry and roles in inflammation and diabetes. Nutraceuticals Fundam Foods [Ed. G.K. Jayaprakasha and Dr. Bhimangouda S.Patil], in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Paris, France, http://www.eolss.net

  • Gonzalez CA, Lujan-Barroso L, Bueno-De-Mesquita HB et al (2012) Fruit and vegetable intake and the risk of gastric adenocarcinoma: a reanalysis of the european prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-up. Int J Cancer 131(12):2910–2919

    Article  CAS  PubMed  Google Scholar 

  • Grassi D, Desideri G, Necozione S et al (2008) Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr 138(9):1671–1676

    CAS  PubMed  Google Scholar 

  • Grassia D, Mulder TPJ, Draijer R et al (2009) Black tea consumption dose-dependently improves flow-mediated dilation in healthy males. J Hypertens 27(4):774–781

    Article  CAS  Google Scholar 

  • Greyling A, Ras Rt, Zoek PL et al (2014) The effect of black tea on blood pressure: a systematic review with meta-analysis of randomized controlled trials. PLoS ONE 9(7). doi:10.137/journal.pone.0103247

  • Hakim IA, Harris RB, Brown S et al (2003) Effect of increased tea consumption on oxidative DNA damage among smokers: a randomized controlled study. J Nutr 133(10):3303S–3309S

    CAS  PubMed  Google Scholar 

  • Hartley L, Flowers N, Holmes J et al (2013) Green and black tea for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. doi:10.1002/14651858.CD009934.pub2

  • Hassellund SS, Flaa A, Sandvik L et al (2012) Effects of anthocyanins on blood pressure and stress reactivity: a double-blind randomized placebo-controlled crossover study. J Hum Hypertens 26(6):396–404

    Article  CAS  PubMed  Google Scholar 

  • Hassellund SS, Flaa A, Kjeldsen SE et al (2013) Effects of anthocyanins on cardiovascular risk factors and inflammation in pre-hypertensive men: a double-blind randomized placebo-controlled crossover study. J Hum Hypertens 27(2):100–106

    Article  CAS  PubMed  Google Scholar 

  • He FJ, Nowson CA, MacGregor GA (2006) Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet 367(9507):320–326

    Article  PubMed  Google Scholar 

  • Hillestrøm PR, Covas M-, Poulsen HE (2006) Effect of dietary virgin olive oil on urinary excretion of etheno-DNA adducts. Free Rad Biol Med 41(7):1133–1138

    Article  PubMed  CAS  Google Scholar 

  • Hodgson JM, Puddey IB, Woodman RJ et al (2012) Effects of black tea on blood pressure: a randomized controlled trial. Arch Intern Med 172(2):186–188

    Article  PubMed  Google Scholar 

  • Hooper L, Kroon PA, Rimm EB et al (2008) Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 88(1):38–50

    CAS  PubMed  Google Scholar 

  • Hooper L, Kay C, Abdelhamid A et al (2012) Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr 95(3):740–751

    Article  CAS  PubMed  Google Scholar 

  • Jepson RG, Craig JC (2008) Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. doi:10.10002/14651858.CD001321.pub4

  • Jepson RG, Williams G, Craig JC (2013) Cranberries for preventing urinary tract infections. Sao Paulo Med J 131(5):363

    Article  Google Scholar 

  • Jiang R, Manson JE, Stampfer MJ et al (2002) Nut and peanut butter consumption and risk of type 2 diabetes in women. J Am Med Assoc 288(20):2554–2560

    Article  Google Scholar 

  • Jin Y, Alimbetov D, George T et al (2011) A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects. Eur J Clin Nutr 65(7):849–856

    Article  CAS  PubMed  Google Scholar 

  • Karakaya S, El SN, Tas AA (2001) Antioxidant activity of some foods containing phenolic compounds. Int J Food Sci Nutr 52(6):501–508

    Article  CAS  PubMed  Google Scholar 

  • Karlsen A, Retterstøl L, Laake P et al (2007) Anthocyanins inhibit nuclear factor-κB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. J Nutr 137(8):1951–1954

    CAS  PubMed  Google Scholar 

  • Kechagias S, Zanjani S, Gjellan S et al (2011) Effects of moderate red wine consumption on liver fat and blood lipids: a prospective randomized study. Ann Med 43(7):545–554

    Article  CAS  PubMed  Google Scholar 

  • Khokhar S, Magnusdottir SGM (2002) Total phenol, catechin, and caffeine contents of teas commonly consumed in the United Kingdom. J Agric Food Chem 50(3):565–570

    Article  CAS  PubMed  Google Scholar 

  • Knekt P, Kumpulainen J, Järvinen R et al (2002) Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 76(3):560–568

    CAS  PubMed  Google Scholar 

  • Krikorian R, Shidler MD, Nash TA et al (2010a) Blueberry supplementation improves memory in older adults. J Agric Food Chem 58(7):3996–4000

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Krikorian R, Nash TA, Shidler MD et al (2010b) Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr 103(5):730–734

    Article  CAS  PubMed  Google Scholar 

  • Krikorian R, Boespflug EL, Fleck DE et al (2012) Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem 60(23):5736–5742

    Article  CAS  PubMed  Google Scholar 

  • Kurowska EM, Spence JD, Jordan J et al (2000) HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 72(5):1095–1100

    CAS  PubMed  Google Scholar 

  • Lim TK (ed) (2012) Edible medicinal and non-medicinal plants: volume 4, fruits. Springer, Netherlands

    Google Scholar 

  • Lindsay J, Laurin D, Verreault R et al (2002) Risk factors for Alzheimer’s disease: a prospective analysis from the Canadian study of health and aging. Am J Epidemiol 156(5):445–453

    Article  PubMed  Google Scholar 

  • Lugasi A, Hóvári J (2003) Antioxidant properties of commercial alcoholic and nonalcoholic beverages. Food 47(2):79–86

    CAS  PubMed  Google Scholar 

  • Luximon-Ramma A, Bahorun T, Crozier A et al (2005) Characterization of the antioxidant functions of flavonoids and proanthocyanidins in Mauritian black teas. Food Res Int 38(4):357–367

    Article  CAS  Google Scholar 

  • Ma Y, Njike VY, Millet J et al (2010) Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial. Diabetes Care 33(2):227–232

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Manach C, Scalbert A, Morand C et al (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79:727–747

    CAS  PubMed  Google Scholar 

  • Marrugat J, Covas M-, Fitó M et al (2004) Effects of differing phenolic content in dietary olive oil on lipids and LDL oxidation: a randomized controlled trial. Eur J Nutr 43(3):140–147

    Article  CAS  PubMed  Google Scholar 

  • McCullough ML, Peterson JJ, Patel R et al (2012) Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr 95(2):454–464

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Michael Allan G, Nicolle L (2013) Cranberry for preventing urinary tract infection. Can Fam Physician 59(4):367

    PubMed  Google Scholar 

  • Miller KB, Stuart DA, Smitih NL et al (2006) Antioxidant activity and polyphenol and procyanidin contents of selected commercially available cocoa-containing and chocolate products in the United States. J Agric Food Chem 54(11):4062–4068

  • Moller P, Loft S, Alfthan G et al (2004) Oxidative DNA damage in circulating mononuclear blood cells after ingestion of blackcurrant juice or anthocyanin-rich drink. Mutat Res Fundam Mol Mech Mutagen 551(1–2):119–126

    Article  CAS  Google Scholar 

  • Morand C, Dubray C, Milenkovic D et al (2011) Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 93(1):73–80

    Article  CAS  PubMed  Google Scholar 

  • Moreno-Luna R, Muñoz-Hernandez R, Miranda ML et al (2012) Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am J Hypertens 25(12):1299–1304

    CAS  PubMed  Google Scholar 

  • Moyer RA, Hummer KE, Finn CE et al (2002) Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: Vaccinium, Rubus, and Ribes. J Agric Food Chem 50(3):519–525

    Article  CAS  PubMed  Google Scholar 

  • Mubarak A, Bondonno CP, Liu AH et al (2012) Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial. J Agric Food Chem 60(36):9130–9136

    Article  CAS  PubMed  Google Scholar 

  • Munir KM, Chandrasekaran S, Gao F et al (2013) Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications. Am J Phys Endocrinol Metab 305(6):E679–E686

    Article  CAS  Google Scholar 

  • Muniyappa R, Hall G, Kolodziej TL et al (2008) Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension. Am J Clin Nutr 88(6):1685–1696

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Munro AJ (2014) Comparative cancer survival in European countries. Br Med Bull 110(1):5–22

    Article  PubMed  Google Scholar 

  • Mursu J, Voutilainen S, Nurmi T et al (2004) Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Radic Biol Med 37(9):1351–1359

    Article  CAS  PubMed  Google Scholar 

  • Naruszewicz M, Laniewska I, Millo B et al (2007) Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI). Atherosclerosis 194(2):e179–e184

    Article  CAS  PubMed  Google Scholar 

  • Natella F, Nardini M, Belelli F et al (2007) Coffee drinking induces incorporation of phenolic acids into LDL and increases the resistance of LDL to ex vivo oxidation in humans. Am J Clin Nutr 86(3):604–609

    CAS  PubMed  Google Scholar 

  • Natella F, Nardini M, Belelli F et al (2008) Effect of coffee drinking on platelets: inhibition of aggregation and phenols incorporation. Br J Nutr 100(6):1276–1282

    Article  CAS  PubMed  Google Scholar 

  • Nicklett EJ, Semba RD, Xue Q- et al (2012) Fruit and vegetable intake, physical activity, and mortality in older community-dwelling women. J Am Geriatr Soc 60(5):862–868

    Article  PubMed  PubMed Central  Google Scholar 

  • Ortega RM (2006) Importance of functional foods in the Mediterranean diet. Public Health Nutr 9(8A):1136–1140

    Article  CAS  PubMed  Google Scholar 

  • Pase MP, Scholey AB, Pipingas A et al (2013) Cocoa polyphenols enhance positive mood states but not cognitive performance: a randomized, placebo-controlled trial. J Psychopharmacol 27:451–458

    Article  CAS  PubMed  Google Scholar 

  • Pérez-Sánchez A, Barrajón-Catalán E, Caturla N et al (2014) Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers. J Photochem Photobiol B Biol 136:12–18

    Article  CAS  Google Scholar 

  • Pitsavos C, Panagiotakos DB, Tzima N et al (2005) Adherence to the Mediterranean diet is associated with total antioxidant capacity in healthy adults: the ATTICA study. Am J Clin Nutr 82(3):694–699

    CAS  PubMed  Google Scholar 

  • Ras RT, Zock PL, Draijer R (2011) Tea consumption enhances endothelial-dependent vasodilation; a meta-analysis. PLoS ONE 6(3). doi:10.137/journal.pone.0016974

  • Ried K, Sullivan TR, Fakler P et al (2012) Effect of cocoa on blood pressure. Cochrane database Syst Rev. doi:10.1002/14651858.CD008893.pub2

  • Rimbach G, Melchin M, Moehring J et al (2009) Polyphenols from cocoa and vascular health—a critical review. Int J Mol Sci 10(10):4290–4309

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Riso P, Visioli F, Gardana C et al (2005) Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress. J Agric Food Chem 53(4):941–947

    Article  CAS  PubMed  Google Scholar 

  • Riso P, Klimis-Zacas D, Del Bo’ C et al (2013) Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors. Eur J Nutr 52(3):949–961

    Article  CAS  PubMed  Google Scholar 

  • Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T et al (2013) Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr 98(5):1179–1191

    Article  CAS  PubMed  Google Scholar 

  • Rodriguez-Mateos A, Vauzour D, Krueger CG et al (2014a) Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update. Arch Toxicol 88(10):1803–1853

    Article  CAS  PubMed  Google Scholar 

  • Rodriguez-Mateos A, Heiss C, Borges G et al (2014b) Berry (poly)phenols and cardiovascular health. J Agric Food Chem 62(18):3842–3851

    Article  CAS  PubMed  Google Scholar 

  • Sahebkar A (2013) Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev 71(12):822–835

    Article  PubMed  Google Scholar 

  • Sánchez-González I, Jiménez-Escrig A, Saura-Calixto F (2005) In vitro antioxidant activity of coffees brewed using different procedures (Italian, espresso and filter). Food Chem 90(1–2):133–139

    Article  CAS  Google Scholar 

  • Scholey AB, French SJ, Morris PJ et al (2010) Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort. J Psychopharmacol 24(10):1505–1514

    Article  CAS  PubMed  Google Scholar 

  • Schwartz JL, Baker V, Larios E et al (2005) Molecular and cellular effects of green tea on oral cells of smokers: a pilot study. Mol Nutr Food Res 49(1):43–51

    Article  CAS  PubMed  Google Scholar 

  • Shin C (2014) The effects of cranberries on preventing urinary tract infections. Clin Nurs Res 23(1):54–79

    Article  PubMed  Google Scholar 

  • Shrime MG, Bauer SR, McDonald AC et al (2011) Flavonoid-Rich cocoa consumption affects multiple cardiovascular risk factors in a meta-analysis of short-term studies. J Nutr 141(11):1982–1988

    Article  CAS  PubMed  Google Scholar 

  • Siasos G, Tousoulis D, Kokkou E et al (2014) Favorable effects of concord grape juice on endothelial function and arterial stiffness in healthy smokers. Am J Hypertens 27(1):38–45

    Article  CAS  PubMed  Google Scholar 

  • Sorond FA, Lipsitz LA, Hollenberg NK et al (2008) Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans. Neuropsychiatr Dis Treat 4(2):433–440

    CAS  PubMed  PubMed Central  Google Scholar 

  • Spaak J, Merlocco AC, Soleas GJ et al (2008) Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter. Am J Physiol Heart C 294(2):H605–H612

    Article  CAS  Google Scholar 

  • Steffen M, Kuhle C, Hensrud D et al (2012) The effect of coffee consumption on blood pressure and the development of hypertension: a systematic review and meta-analysis. J Hypertens 30(12):2245–2254

    Article  CAS  PubMed  Google Scholar 

  • Steptoe A, Gibson EL, Vuononvirta R et al (2007) The effects of chronic tea intake on platelet activation and inflammation: a double-blind placebo controlled trial. Atherosclerosis 193(2):277–282

    Article  CAS  PubMed  Google Scholar 

  • Stull AJ, Cash KC, Johnson WD et al (2010) Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. J Nutr 140(10):1764–1768

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sun J, Chu Y, Wu X et al (2002) Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem 50(25):7449–7454

    Article  CAS  PubMed  Google Scholar 

  • Tabak C, Arts IC, Smit HA et al (2001) Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study. Am J Respir Crit Care Med 164(1):61–64

    Article  CAS  PubMed  Google Scholar 

  • Theodoratou E, Kyle J, Cetnarskyj R et al (2007) Dietary flavonoids and the risk of colorectal cancer. Cancer Epidemiol Biomark Prev 16(4):684–693

    Article  CAS  Google Scholar 

  • Tomé-Carneiro J, Larrosa M, Yáñez-Gascón MJ et al (2013) One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res 72:69–82

    Article  PubMed  CAS  Google Scholar 

  • Tsao AS, Liu D, Martin J et al (2009) Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions. Cancer Prev Res 2(11):931–941

    Article  CAS  Google Scholar 

  • U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 7th Edition, U.S. Government Printing Office, Washington, DC, December 2010

  • U.S. Food and Drug Administration, Qualified Health Claims: Letter of Denial—Green Tea and Reduced Risk of Cardiovascular Disease (2005) (Docket No. 2005Q-0297) 10903 New Hampshire Avenue, Silver Spring, MD 20993

  • U.S. Food and Drug Administration, Qualified Health Claims: Letter Responding to Health Claim Petition dated January 27, 2004: Green Tea and Reduced Risk of Cancer Health Claim (2011) (Docket number FDA-2004-Q-0427), 10903 New Hampshire Avenue, Silver Spring, MD 20993

  • Vitrac X, Bornet A, Vanderlinde R et al (2005) Determination of stilbenes (d-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, e-viniferin) in Brazilian wines. J Agric Food Chem 53(14):5664–5669

    Article  CAS  PubMed  Google Scholar 

  • Wang X (2014) Erratum: Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ. doi:10.1136/bmj.g4490)

    Google Scholar 

  • Wang X, Ouyang YY, Liu J et al (2014) Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies. Br J Nutr 111(1):1–11

    Article  PubMed  CAS  Google Scholar 

  • Weinbrenner T, Fitó M, De La Torre R et al (2004) Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men. J Nutr 134(9):2314–2321

    CAS  PubMed  Google Scholar 

  • Weisel T, Baum M, Eisenbrand G et al (2006) An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands. Biotechnol J 1(4):388–397

    Article  CAS  PubMed  Google Scholar 

  • WHO/FAO Technical Consultation on National Food-Based Dietary Guidelines. WHO, Geneva, Switzerland, 2006

  • WHO Geneva http://www.who.int/mediacentre/factsheets/fs355/en/, Jan 2015

  • Wong RHX, Howe PRC, Buckley JD et al (2011) Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr, Metab Cardiovasc 21(11):851–856

    Article  CAS  Google Scholar 

  • Woo HD, Kim J (2013) Dietary flavonoid intake and risk of stomach and colorectal cancer. World J Gastroenterol 19(7):1011–1019

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yubero N, Sanz-Buenhombre M, Guadarrama A et al (2013) LDL cholesterol-lowering effects of grape extract used as a dietary supplement on healthy volunteers. Int J Food Sci Nutr 64(4):400–406

    Article  CAS  PubMed  Google Scholar 

  • Zamora-Ros R, Jiménez C, Cleries R et al (2013) Dietary flavonoid and lignan intake and mortality in a Spanish cohort. Epidemiology 24(5):726–733

    Article  PubMed  Google Scholar 

  • Zhu Y, Xia M, Yang Y et al (2011) Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clin Chem 57(11):1524–1533

    Article  CAS  PubMed  Google Scholar 

  • Zhu Y, Ling W, Guo H et al (2013) Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial. Nutr Metab Cardiovasc 23(9):843–849

    Article  CAS  Google Scholar 

  • Zhu L, Pickle LW, Zou Z et al (2014) Trends and patterns of childhood cancer incidence in the United States, 1995–2010. Stat Interface 7(1):121–134

    Article  Google Scholar 

  • Zunino SJ, Parelman MA, Freytag TL et al (2012) Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects. Br J Nutr 108(5):900–909

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento de Química Agrícola y Bromatología, Facultad de Ciencias, Instituto de Investigación de Ciencias de la Alimentación CSIC-UAM, Campus de la Universidad Autónoma de Madrid, 28049, Madrid, Spain

    Yolanda Aguilera & Maria Angeles Martin-Cabrejas

  2. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 228 ERML, MC-051, 1201 West Gregory Drive, Urbana, IL, 61801, USA

    Yolanda Aguilera & Elvira González de Mejia

Authors
  1. Yolanda Aguilera
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria Angeles Martin-Cabrejas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Elvira González de Mejia
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elvira González de Mejia.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aguilera, Y., Martin-Cabrejas, M.A. & González de Mejia, E. Phenolic compounds in fruits and beverages consumed as part of the mediterranean diet: their role in prevention of chronic diseases. Phytochem Rev 15, 405–423 (2016). https://doi.org/10.1007/s11101-015-9443-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11101-015-9443-z

Keywords

Search

Navigation