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Phytochemistry Reviews

, Volume 13, Issue 1, pp 295–322 | Cite as

Anticancer effects of bioactive berry compounds

  • Florence Folmer
  • Umesh Basavaraju
  • Marcel Jaspars
  • Georgina Hold
  • Emad El-Omar
  • Mario Dicato
  • Marc DiederichEmail author
Article

Abstract

In the present review, we describe chemical and chemopreventive properties as well as health benefits of both extracts and bioactive compounds from various types of berries including small soft-fleshed edible berries and from berry-like fruits such as strawberries, raspberries, blackberries, blueberries, mulberries, currants, gooseberries, elderberries, açai berries, and pomegranates. In particular, we describe how berry-derided phytochemicals, including anthocyanidins, proanthocyanidins, flavonols, flavanols, stilbenoids, terpenoids, ellagitannins, and ellagic acid target oxidative and UV radiation stress-induced DNA damage, Helicobacter pilori infection, pro-inflammatory as well as the major cancer hallmarks.

Keywords

Anthocyanin Anti-cancer Anti-inflammatory Anti-oxidant Berry Flavonoid 

Abbreviations

AP-1

Activation protein 1

BAD

Bcl-2 associated death promoter

Bcl-2

B cell lymphoma-2

cdk

Cyclin dependent kinase

COX

Cyclooxygenase

ERK

Extracellular signal-related kinase

IL

Interleukin

iNOS

Inducible nitric oxide synthase

JAK

Janus kinase

JNK

c-Jun N-terminal kinase

LPS

Lipopolysaccharide

MAP2K

MAPK kinase

MAP3K

MAP2K kinase

MAPK

Mitogen-activated protein kinase

MMP

Matrix metalloproteinase

NF-κB

Nuclear factor-κB

NO

Nitric oxide

ORAC

Oxygen radical absorbance capacities

PGE2

Prostaglandin E2

PI-3 K

Phosphoinositide 3-kinase

PKC

Protein kinase C

PIP2

Phosphatidylinostol (3,4)-bisphosphate

PIP3

Phosphatidylinostol (3,4,5)-triphosphate

Rb

Retinoblastoma protein

ROS

Reactive oxygen species

SAR

Structure–activity relationship

STAT

Signal transducer and activator of transcription

TIMP

Tissue inhibitor of matrix proteinase

TNF-α

Transcription factor-α

USDA

United States Department of Agriculture

UV

Ultraviolet

VEGF

Vascular endothelial growth factor

Notes

Acknowledgments

Research at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC) is financially supported by “Recherche Cancer et Sang” foundation, by «Recherches Scientifiques Luxembourg» asbl, by «Een Häerz fir Kriibskrank Kanner» association, the Action Lions “Vaincre le Cancer” Luxembourg, The Fonds National de la Recherche Luxembourg, Televie Luxembourg and the Foundation for Scientific Cooperation between Germany and Luxemburg is thanked for additional support. Further support was received from the European Union (ITN “RedCat” 215009 and Interreg IVa project “Corena”). MD is supported by the National Research Foundation (NRF) by the MEST of Korea for Tumor Microenvironment Global Core Research Center (GCRC) grant, [Grant Number 2012-0001184]; by the Seoul National University Research grant and by the Research Settlement Fund for the new faculty of SNU.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Florence Folmer
    • 1
    • 2
    • 3
  • Umesh Basavaraju
    • 2
  • Marcel Jaspars
    • 3
  • Georgina Hold
    • 2
  • Emad El-Omar
    • 2
  • Mario Dicato
    • 1
  • Marc Diederich
    • 4
    Email author
  1. 1.Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et SangHôpital KirchbergLuxembourgLuxembourg
  2. 2.Division of Applied Medicine, Institute of Medical Science, School of Medicine and DentistryUniversity of AberdeenAberdeenScotland, UK
  3. 3.Marine Biodiscovery Centre, Chemistry Department, School of Natural and Computing SciencesUniversity of AberdeenAberdeenScotland, UK
  4. 4.Tumor Microenvironment Global Core Research Center, College of PharmacySeoul National UniversitySeoulRepublic of Korea

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