Phytochemistry Reviews

, Volume 13, Issue 1, pp 295–322 | Cite as

Anticancer effects of bioactive berry compounds

  • Florence Folmer
  • Umesh Basavaraju
  • Marcel Jaspars
  • Georgina Hold
  • Emad El-Omar
  • Mario Dicato
  • Marc DiederichEmail author


In the present review, we describe chemical and chemopreventive properties as well as health benefits of both extracts and bioactive compounds from various types of berries including small soft-fleshed edible berries and from berry-like fruits such as strawberries, raspberries, blackberries, blueberries, mulberries, currants, gooseberries, elderberries, açai berries, and pomegranates. In particular, we describe how berry-derided phytochemicals, including anthocyanidins, proanthocyanidins, flavonols, flavanols, stilbenoids, terpenoids, ellagitannins, and ellagic acid target oxidative and UV radiation stress-induced DNA damage, Helicobacter pilori infection, pro-inflammatory as well as the major cancer hallmarks.


Anthocyanin Anti-cancer Anti-inflammatory Anti-oxidant Berry Flavonoid 



Activation protein 1


Bcl-2 associated death promoter


B cell lymphoma-2


Cyclin dependent kinase




Extracellular signal-related kinase




Inducible nitric oxide synthase


Janus kinase


c-Jun N-terminal kinase




MAPK kinase


MAP2K kinase


Mitogen-activated protein kinase


Matrix metalloproteinase


Nuclear factor-κB


Nitric oxide


Oxygen radical absorbance capacities


Prostaglandin E2

PI-3 K

Phosphoinositide 3-kinase


Protein kinase C


Phosphatidylinostol (3,4)-bisphosphate


Phosphatidylinostol (3,4,5)-triphosphate


Retinoblastoma protein


Reactive oxygen species


Structure–activity relationship


Signal transducer and activator of transcription


Tissue inhibitor of matrix proteinase


Transcription factor-α


United States Department of Agriculture




Vascular endothelial growth factor



Research at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC) is financially supported by “Recherche Cancer et Sang” foundation, by «Recherches Scientifiques Luxembourg» asbl, by «Een Häerz fir Kriibskrank Kanner» association, the Action Lions “Vaincre le Cancer” Luxembourg, The Fonds National de la Recherche Luxembourg, Televie Luxembourg and the Foundation for Scientific Cooperation between Germany and Luxemburg is thanked for additional support. Further support was received from the European Union (ITN “RedCat” 215009 and Interreg IVa project “Corena”). MD is supported by the National Research Foundation (NRF) by the MEST of Korea for Tumor Microenvironment Global Core Research Center (GCRC) grant, [Grant Number 2012-0001184]; by the Seoul National University Research grant and by the Research Settlement Fund for the new faculty of SNU.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Florence Folmer
    • 1
    • 2
    • 3
  • Umesh Basavaraju
    • 2
  • Marcel Jaspars
    • 3
  • Georgina Hold
    • 2
  • Emad El-Omar
    • 2
  • Mario Dicato
    • 1
  • Marc Diederich
    • 4
    Email author
  1. 1.Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et SangHôpital KirchbergLuxembourgLuxembourg
  2. 2.Division of Applied Medicine, Institute of Medical Science, School of Medicine and DentistryUniversity of AberdeenAberdeenScotland, UK
  3. 3.Marine Biodiscovery Centre, Chemistry Department, School of Natural and Computing SciencesUniversity of AberdeenAberdeenScotland, UK
  4. 4.Tumor Microenvironment Global Core Research Center, College of PharmacySeoul National UniversitySeoulRepublic of Korea

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