Phytochemistry Reviews

, 5:373

Cytochrome P450 oxygenases of monoterpene metabolism

Original Paper

DOI: 10.1007/s11101-006-9008-2

Cite this article as:
Mau, C.J.D. & Croteau, R. Phytochem Rev (2006) 5: 373. doi:10.1007/s11101-006-9008-2

Abstract

The cytochrome P450 monoterpene oxygenases are largely responsible for imparting structural and functional diversity to this family of natural products. In most cases, cytochrome P450-mediated allylic hydroxylation of a parental monoterpene olefin leads to a series of redox transformations and conjugation reactions which yield a family of structurally related derivatives and isomers. An overview is provided of the extant monoterpene oxygenases, with examples mainly from the mint (Lamiaceae) family of essential oil plants, and, where possible, information on the structure, mechanism, localization and regulation of these enzymes is described. The review concludes with a brief assessment of biotechnological applications and a view to future research in this area.

Keywords

Hydroxylase Lamiaceae 

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  1. 1.Institute of Biological ChemistryWashington State UniversityPullmanUSA

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