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International Journal of Clinical Pharmacy

, Volume 40, Issue 6, pp 1458–1461 | Cite as

Effectiveness of antibiotic therapy in pediatric patients with cat scratch disease

  • Loujain A. Shorbatli
  • Katalin I. Koranyi
  • Milap C. NahataEmail author
Short Research Report
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Abstract

Background Appropriate antibiotic treatment of cat scratch disease (CSD) in pediatrics is not well established. Objective The purpose of this study was to evaluate the response rates of antibiotic therapy in pediatrics with CSD. Methods The electronic medical records of a cohort of pediatric patients with confirmed diagnosis of CSD (2006–2016) were reviewed, retrospectively. Data collection included patient demographics, clinical and laboratory results, antibiotic treatment and follow-up evaluations. Results One hundred and seventy-five patients (aged 7.4 ± 4.4 years) had confirmed CSD. Azithromycin and trimethoprim/sulfamethoxazole (TMP/SMX) were the largest groups with documented effectiveness at follow-up visits. Resolution and improvement of CSD was observed in 51.4% and 61.5% of patients with azithromycin and TMP/SMX, respectively among those with follow-up assessment. The effectiveness of azithromycin and TMP/SMX was comparable (p = 0.56). Conclusion Azithromycin and TMP/SMX were most frequently prescribed antibiotics. Azithromycin appeared to be an appropriate option for the treatment of CSD. TMP/SMX may be considered as an alternative antibiotic when azithromycin cannot be used.

Keywords

Antibiotic therapy Azithromycin Cat scratch disease Pediatrics Trimethoprim/sulfamethoxazole 

Notes

Acknowledgements

We appreciate the assistance of Dr. Junan Li at the College of Pharmacy, The Ohio State University for the statistical analysis of the data.

Funding

No external funding was obtained for this study.

Conflicts of interest

The authors had no conflicts of interest.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Loujain A. Shorbatli
    • 1
  • Katalin I. Koranyi
    • 2
  • Milap C. Nahata
    • 1
    • 2
    Email author
  1. 1.College of PharmacyThe Ohio State UniversityColumbusUSA
  2. 2.College of MedicineNationwide Children’s HospitalColumbusUSA

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